Efficacy of N-acetylcysteine Treatment in Methimazole-induced Myopathy and Toxic Hepatitis
Turkiye Klinikleri J Case Rep. 2020;28(4):266-71
doi: 10.5336/caserep.2020-77783
Makale Dili: EN
Tam Metin
ABSTRACT
Today, antithyroid drugs are widely used in the treatment of hyperthyroidism. Elevated creatine kinase and liver injury (hepatitis) caused by methimazole are some of rare side effects. Elevation of creatine kinase (CK) should be monitored due to the risk of rhabdomyolysis development. Also, drug-induced liver injury can be seen. In this article, we report a patient who received methimazole 2 months ago for hyperthyroidism, but then began to have complaints like muscle pain, jaundice (icterus) in the eyes along with itching and dark urine, and found out to have elevated CK as well as liver enzymes induced by liver injury, thus showed rapid recovery upon N-acetylcysteine treatment.
Keywords: Hyperthyroidism; myalgia; creatine kinase; liver injury; icterus
Today, antithyroid drugs are widely used in the treatment of hyperthyroidism. Elevated creatine kinase and liver injury (hepatitis) caused by methimazole are some of rare side effects. Elevation of creatine kinase (CK) should be monitored due to the risk of rhabdomyolysis development. Also, drug-induced liver injury can be seen. In this article, we report a patient who received methimazole 2 months ago for hyperthyroidism, but then began to have complaints like muscle pain, jaundice (icterus) in the eyes along with itching and dark urine, and found out to have elevated CK as well as liver enzymes induced by liver injury, thus showed rapid recovery upon N-acetylcysteine treatment.
Keywords: Hyperthyroidism; myalgia; creatine kinase; liver injury; icterus
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