.: ORİJİNAL ARAŞTIRMA
Associations Between Body Mass Index and Hematological Parameters in Obese and Normal-Weight Adolescents: A Cross-Sectional Study
Obez ve Normal Ağırlıklı Adölesanlarda Beden Kitle İndeksi ve Hematolojik Parametreler Arasındaki İlişkiler: Kesitsel Çalışma
Turkiye Klinikleri J Med Sci. 2025;45(2):85-91
doi: 10.5336/medsci.2024-105697
Makale Dili: EN
Tam Metin
Ücretsiz Erişim
ABSTRACT
Objective: Although many studies are showing that obesity is an inflammatory condition, to our knowledge, there are few studies showing the effects of obesity on erythrocyte indices and thrombotic risk in adolescence. This study aimed to investigate the impact of obesity on these hematological parameters in an adolescent cohort. Material and Methods: This is a cross-sectional study in which 52 obese (body mass index (BMI)>30) and 60 normal-weight (BMI=20-25) adolescents aged 10-19 participated. Weight, height, BMI, and blood count parameters were included in the study. The obese and control groups were matched for age and gender (p=0.08, p=0.26). Results: The mean age of the obese group was 14±3.7 years, and the normal-weight group was 15±2.42. While the male/female ratio in the obese group was 34/18, in the control group this ratio was 33/27. When we examined the blood count parameters between the 2 groups, significant differences were found between the Red Blood Cells (RBC), mean corpuscular volume (MCV), Platelet Distribution Width (PDW), and neutrophil to lymphocyte ratio (NLR) parameters, respectively. (p=0.009, p=0.038, p=0.03, p=0.02). In the correlation analysis between blood count parameters and BMI, it was seen that the positive correlation with RBC was significant and the negative correlations with MCV and NLR were significant. (p=0.006, p=0.01, p=0.03). In multivariate binary regression analysis, the independent negative association between RBC and obesity was significant (p=0.028). Conclusion: The significant relationship between BMI and RBC, MCV, PDW, and NLR in the adolescent age group in our study indicates that obesity may be associated with thrombosis and vascular disease, which are shown by hematological parameters in adolescence. Future studies using blood count parameters and indices in this age group should take into account the participants' BMI.
Keywords: Adolecents; hematological parameters; obesity
Objective: Although many studies are showing that obesity is an inflammatory condition, to our knowledge, there are few studies showing the effects of obesity on erythrocyte indices and thrombotic risk in adolescence. This study aimed to investigate the impact of obesity on these hematological parameters in an adolescent cohort. Material and Methods: This is a cross-sectional study in which 52 obese (body mass index (BMI)>30) and 60 normal-weight (BMI=20-25) adolescents aged 10-19 participated. Weight, height, BMI, and blood count parameters were included in the study. The obese and control groups were matched for age and gender (p=0.08, p=0.26). Results: The mean age of the obese group was 14±3.7 years, and the normal-weight group was 15±2.42. While the male/female ratio in the obese group was 34/18, in the control group this ratio was 33/27. When we examined the blood count parameters between the 2 groups, significant differences were found between the Red Blood Cells (RBC), mean corpuscular volume (MCV), Platelet Distribution Width (PDW), and neutrophil to lymphocyte ratio (NLR) parameters, respectively. (p=0.009, p=0.038, p=0.03, p=0.02). In the correlation analysis between blood count parameters and BMI, it was seen that the positive correlation with RBC was significant and the negative correlations with MCV and NLR were significant. (p=0.006, p=0.01, p=0.03). In multivariate binary regression analysis, the independent negative association between RBC and obesity was significant (p=0.028). Conclusion: The significant relationship between BMI and RBC, MCV, PDW, and NLR in the adolescent age group in our study indicates that obesity may be associated with thrombosis and vascular disease, which are shown by hematological parameters in adolescence. Future studies using blood count parameters and indices in this age group should take into account the participants' BMI.
Keywords: Adolecents; hematological parameters; obesity
ÖZET
Amaç: Obezitenin bir inflamasyon durumu olduğunu gösteren fazlaca çalışma olmasına rağmen, bildiğimiz kadarıyla adölesan dönemde obezitenin eritrosit indeksleri ve trombotik risk üzerindeki etkilerini gösteren az sayıda çalışma bulunmaktadır. Bu çalışma ile adolesan bir kohort üzerinde obezitenin bu hematolojik parametreler üzerindeki etkilerinin araştırılması amaçlandı. Gereç ve Yöntemler: Bu çalışma, 10-19 yaşlarındaki 52 obez (beden kitle indeksi (BKİ)>30) ve 60 normal kilolu (BKİ=20-25) adölesanın katıldığı kesitsel bir çalışmadır. Çalışmaya ağırlık, boy, BKİ ve kan sayımı parametreleri dâhil edildi. Obez ve kontrol grupları yaş ve cinsiyet açısından eşleştirildi (p=0,08, p=0,26). Bulgular: Obez grubun yaş ortalaması 14±3,7, normal kilolu grubun yaş ortalaması ise 15±2,42 idi. Obez grupta erkek/kadın oranı 34/18 iken kontrol grubunda bu oran 33/27 idi. İki grup arasındaki kan sayımı parametrelerini incelediğimizde sırasıyla kırmızı kan hücresi [red blood cells (RBC)], ortalama hücre hacmi [mean corpuscular volume (MCV)], trombosit dağılım genişliği [platelet distribution width (PDW)] ve nötrofil lenfosit oranı [neutrophil to lymphocyte ratio (NLR)] parametreleri arasında anlamlı farklar tespit edildi (p=0,009, p=0,038, p=0,03, p=0,02). Kan sayımı parametreleri ile BKİ arasındaki korelasyon analizlerinde RBC ile pozitif korelasyonun anlamlı, MCV ve NLR ile negatif korelasyonun anlamlı olduğunu görüldü (p=0,006, p=0,01, p=0,03). Çok değişkenli ikili regresyon analizinde ise RBC'nin obezite ile bağımsız negatif ilişkisi anlamlıydı (p=0,028). Sonuç: Çalışmamızda adölesan yaş grubunda BKİ ile RBC, MCV, PDW ve NLR arasında anlamlı ilişki bulunması, obezitenin ergenlik döneminde hematolojik parametrelerle gösterilen tromboz ve vasküler hastalıklarla ilişkili olabileceğini göstermektedir. Araştırmada kullanılan yaş grubunda kan sayımı parametreleri ve indekslerinin kullanıldığı gelecekteki çalışmalarda katılımcıların BKİ'leri dikkate alınmalıdır.
Anahtar Kelimeler: Adölesanlar; hematolojik parametreler; obezite
Amaç: Obezitenin bir inflamasyon durumu olduğunu gösteren fazlaca çalışma olmasına rağmen, bildiğimiz kadarıyla adölesan dönemde obezitenin eritrosit indeksleri ve trombotik risk üzerindeki etkilerini gösteren az sayıda çalışma bulunmaktadır. Bu çalışma ile adolesan bir kohort üzerinde obezitenin bu hematolojik parametreler üzerindeki etkilerinin araştırılması amaçlandı. Gereç ve Yöntemler: Bu çalışma, 10-19 yaşlarındaki 52 obez (beden kitle indeksi (BKİ)>30) ve 60 normal kilolu (BKİ=20-25) adölesanın katıldığı kesitsel bir çalışmadır. Çalışmaya ağırlık, boy, BKİ ve kan sayımı parametreleri dâhil edildi. Obez ve kontrol grupları yaş ve cinsiyet açısından eşleştirildi (p=0,08, p=0,26). Bulgular: Obez grubun yaş ortalaması 14±3,7, normal kilolu grubun yaş ortalaması ise 15±2,42 idi. Obez grupta erkek/kadın oranı 34/18 iken kontrol grubunda bu oran 33/27 idi. İki grup arasındaki kan sayımı parametrelerini incelediğimizde sırasıyla kırmızı kan hücresi [red blood cells (RBC)], ortalama hücre hacmi [mean corpuscular volume (MCV)], trombosit dağılım genişliği [platelet distribution width (PDW)] ve nötrofil lenfosit oranı [neutrophil to lymphocyte ratio (NLR)] parametreleri arasında anlamlı farklar tespit edildi (p=0,009, p=0,038, p=0,03, p=0,02). Kan sayımı parametreleri ile BKİ arasındaki korelasyon analizlerinde RBC ile pozitif korelasyonun anlamlı, MCV ve NLR ile negatif korelasyonun anlamlı olduğunu görüldü (p=0,006, p=0,01, p=0,03). Çok değişkenli ikili regresyon analizinde ise RBC'nin obezite ile bağımsız negatif ilişkisi anlamlıydı (p=0,028). Sonuç: Çalışmamızda adölesan yaş grubunda BKİ ile RBC, MCV, PDW ve NLR arasında anlamlı ilişki bulunması, obezitenin ergenlik döneminde hematolojik parametrelerle gösterilen tromboz ve vasküler hastalıklarla ilişkili olabileceğini göstermektedir. Araştırmada kullanılan yaş grubunda kan sayımı parametreleri ve indekslerinin kullanıldığı gelecekteki çalışmalarda katılımcıların BKİ'leri dikkate alınmalıdır.
Anahtar Kelimeler: Adölesanlar; hematolojik parametreler; obezite
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