.: ORİJİNAL ARAŞTIRMA
Adherence to Anti-hypertensive Treatment in Geriatric Patients: A Systematic Review and Meta-analysis
Geriatrik Hastaların Anti-hipertansif Tedaviye Uyumu: Sistematik Derleme ve Metaanaliz
Turkiye Klinikleri J Cardiovasc Sci. 2021;33(2):61-70
doi: 10.5336/cardiosci.2021-81580
Makale Dili: EN
Tam Metin
ABSTRACT
Objective: This study was planned for the systematic review and meta-analysis of the studies evaluating adherence to antihypertensive treatment in geriatric patients. Material and Methods: Google Scholar, Web of Science, PubMed, CINAHL, MEDLINE and Scopus databases were searched using the keywords 'Geriatric, Geriatric patients, Elderly, Elderly patients, Hypertension, Anti-hypertensive agents, Drug compliance'. A total of 13 studies were included in the meta-analysis. The included studies were evaluated with the quality evaluation criteria proposed by Polit and Beck. The agreement between the researchers was measured by the kappa test for agreement. The odds ratio was used for effect sizes, Cochran's Q test was used for heterogeneity, the funnel plot and Kendall's tau coefficient were used for publication bias. Results: Age, gender, educational status, income level, place of residence and presence of comorbid diseases that affect adherence to anti-hypertensive treatment in geriatric patients were examined. The fact that age and presence of comorbid diseases decreased adherence to anti-hypertensive treatment (OR 1) in geriatric patients was confirmed by the meta-analysis. Conclusion: The factors affecting adherence to anti-hypertensive treatment in geriatric patients were found to be similar to the literature. In contrast to the literature, it was found that gender did not affect adherence to anti-hypertensive treatment in any way. This difference was thought to be due to the lack of homogeneity in the samples of the studies.
Keywords: Aged; hypertension; anti-hypertensive agents; treatment adherence
Objective: This study was planned for the systematic review and meta-analysis of the studies evaluating adherence to antihypertensive treatment in geriatric patients. Material and Methods: Google Scholar, Web of Science, PubMed, CINAHL, MEDLINE and Scopus databases were searched using the keywords 'Geriatric, Geriatric patients, Elderly, Elderly patients, Hypertension, Anti-hypertensive agents, Drug compliance'. A total of 13 studies were included in the meta-analysis. The included studies were evaluated with the quality evaluation criteria proposed by Polit and Beck. The agreement between the researchers was measured by the kappa test for agreement. The odds ratio was used for effect sizes, Cochran's Q test was used for heterogeneity, the funnel plot and Kendall's tau coefficient were used for publication bias. Results: Age, gender, educational status, income level, place of residence and presence of comorbid diseases that affect adherence to anti-hypertensive treatment in geriatric patients were examined. The fact that age and presence of comorbid diseases decreased adherence to anti-hypertensive treatment (OR 1) in geriatric patients was confirmed by the meta-analysis. Conclusion: The factors affecting adherence to anti-hypertensive treatment in geriatric patients were found to be similar to the literature. In contrast to the literature, it was found that gender did not affect adherence to anti-hypertensive treatment in any way. This difference was thought to be due to the lack of homogeneity in the samples of the studies.
Keywords: Aged; hypertension; anti-hypertensive agents; treatment adherence
ÖZET
Amaç: Bu çalışma, geriatrik hastalarda anti-hipertansif tedaviye uyumu değerlendiren araştırmaların sistematik derlemesi ve metaanalizi amacıyla planlandı. Gereç ve Yöntemler: Google Scholar, Web of Science, PubMed, CINAHL, MEDLINE ve Scopus veri tabanlarında 'Geriatria, Geriatric patients, Elderly, Elderly patients, Hypertension, Anti-hypertensive agents, Drug compliance' ile tarama yapıldı. Toplam 13 araştırma, meta-analiz kapsamına alındı. Dâhil edilen araştırmalar, Polit ve Beck tarafından önerilen kalite değerlendirme ölçütleri ile değerlendirildi. Araştırmacılar arası uyum, kappa uyum analizi ile ölçüldü. Etki büyüklükleri için olasılık oranı [odds ratio (OR)], heterojenlik için Cochran Q testi, yayın yanlılığı için huni saçılım grafiği ve Kendall tau katsayısı kullanıldı. Bulgular: Geriatrik hastalarda, anti-hipertansif tedaviye uyumu etkileyen yaş, cinsiyet, eğitim durumu, gelir düzeyi, yaşanılan yer ve komorbid hastalığa sahip olma durumları incelendi. Geriatrik hastalarda, yaş ve komorbid hastalığa sahip olma durumunun, anti-hipertansif tedaviye uyumu azaltırken (OR 1) meta-analiz sonucu doğrulandı. Sonuç: Geriatrik hastalarda, anti-hipertansif tedaviye uyumu etkileyen faktörlerin, literatür ile benzer olduğu tespit edildi. Literatürün aksine cinsiyetin, anti-hipertansif tedaviye uyumu herhangi bir şekilde etkilemediği tespit edildi. Bu farkın, çalışmaların örneklemlerinde homojenliğin olmamasından kaynaklanacağı düşünüldü.
Anahtar Kelimeler: Yaşlı; hipertansiyon; anti-hipertansif ilaçlar; tedavi uyumu
Amaç: Bu çalışma, geriatrik hastalarda anti-hipertansif tedaviye uyumu değerlendiren araştırmaların sistematik derlemesi ve metaanalizi amacıyla planlandı. Gereç ve Yöntemler: Google Scholar, Web of Science, PubMed, CINAHL, MEDLINE ve Scopus veri tabanlarında 'Geriatria, Geriatric patients, Elderly, Elderly patients, Hypertension, Anti-hypertensive agents, Drug compliance' ile tarama yapıldı. Toplam 13 araştırma, meta-analiz kapsamına alındı. Dâhil edilen araştırmalar, Polit ve Beck tarafından önerilen kalite değerlendirme ölçütleri ile değerlendirildi. Araştırmacılar arası uyum, kappa uyum analizi ile ölçüldü. Etki büyüklükleri için olasılık oranı [odds ratio (OR)], heterojenlik için Cochran Q testi, yayın yanlılığı için huni saçılım grafiği ve Kendall tau katsayısı kullanıldı. Bulgular: Geriatrik hastalarda, anti-hipertansif tedaviye uyumu etkileyen yaş, cinsiyet, eğitim durumu, gelir düzeyi, yaşanılan yer ve komorbid hastalığa sahip olma durumları incelendi. Geriatrik hastalarda, yaş ve komorbid hastalığa sahip olma durumunun, anti-hipertansif tedaviye uyumu azaltırken (OR 1) meta-analiz sonucu doğrulandı. Sonuç: Geriatrik hastalarda, anti-hipertansif tedaviye uyumu etkileyen faktörlerin, literatür ile benzer olduğu tespit edildi. Literatürün aksine cinsiyetin, anti-hipertansif tedaviye uyumu herhangi bir şekilde etkilemediği tespit edildi. Bu farkın, çalışmaların örneklemlerinde homojenliğin olmamasından kaynaklanacağı düşünüldü.
Anahtar Kelimeler: Yaşlı; hipertansiyon; anti-hipertansif ilaçlar; tedavi uyumu
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