Turkiye Klinikleri Journal of Anesthesiology Reanimation

.: CASE REPORTS
Yoğun Bakım Ünitesinde Yatan Kritik COVID-19 Hastalarında İmmün Plazma Tedavisi: Olgu Serisi
Immune Plasma Therapy in Critical COVID-19 Patients in the Intensive Care Unit: Case Series
Abdulkadir YEKTAŞa, Hakan AKELMAa, Şafak KAYAb, Şeyhmuz KAVAKc, Ömer CANa, Zeki KORHANa, Mesut TÜRKa, Mehmet Serdar YILDIRIMd, Yılmaz MERTSOYe, Mehmet Salih GÜLa
aSağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Anesteziyoloji ve Reanimasyon Kliniği, Yoğun Bakım Yan Dal Kliniği, Diyarbakır,TÜRKİYE
bSağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Klinik Mikrobiyoloji ve Enfeksiyon Hastalıkları Kliniği, Diyarbakır, TÜRKİYE
cSağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Radyoloji Kliniği, Diyarbakır, TÜRKİYE
dSağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, Diyarbakır, TÜRKİYE
eSağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, Diyarbakır, TÜRKİYE
Turkiye Klinikleri J Anest Reanim. 2020;18(3):100-22
doi: 10.5336/anesthe.2020-76699
Article Language: TR
Full Text
ÖZET
 SARS-CoV-2, daha önce insan ve hayvanlardan izole edilmemiş yeni bir koronavirüs [coronavirus (CoV)] suşudur. İnsanlarda, COVID19 hastalığına yol açar. COVID-19, sistemik bir hastalıktır. Bazı COVID-19 hastaları, hastalığı ağır geçirir ve bu esnada yoğun bakım ünitesi (YBÜ)ne alınırlar. Bu hastalarda, SARS-CoV-2 virüsünün neden olduğu sitokin fırtınası hem 7 günden önceki erken dönemde hem de 2. dalga olarak 7-10. günlerde gelişebilir. Sitokin fırtınası, bu hastalığın gidişatını kötüleştirir. Mutlaka tedavi edilmelidir. Hastalar, SARS-CoV2 virüsünü bertaraf edebilmek için virüse karşı etkin antikor üretirler. Tedavide, COVID-19 hastalığını atlatan uygun donörlerden immün plazma alınır ve hastalığı ağır atlatan hastalara verilebilir. Bu olgu serisinde, SARS-CoV-2 virüsüyle enfekte olmuş, YBÜ'ye alınan 5'i vefat eden, 7 COVID-19 hastasının tedavisini ve bu tedaviye immün plazmanın etkilerini sunmayı amaçladık.

Anahtar Kelimeler: SARS-CoV-2; COVID-19; sitokin fırtınası; immün plazma tedavisi
ABSTRACT
 SARS-CoV-2 is a new strain of coronavirus (CoV) not previously isolated from humans and animals. It causes COVID-19 disease in humans. COVID-19 is a systemic disease. Some COVID19 patients suffer from the disease and are taken to the intensive care unit. In these patients, the cytokine storm caused by the SARS-CoV2 virus is both early in the 7 days and 7-10 as the second wave may develop in days. Cytokine storm worsens the course of this disease. It must be treated. Patients produce anti-virus antibodies to eliminate the SARS-CoV-2 virus. In treatment, immune plasma is taken from suitable donors that survive COVID-19 disease and can be given to these patients who have suffer from the disease. In this case series, we aimed to treat the 7 COVID-19 patients with 5 ex who were taken to the intensive care unit infected with the SARS-CoV-2 virus and the effects of immune plasma to this treatment.

Keywords: SARS-CoV-2; COVID-19; cytokine storm; immune plasma therapy
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30.03.2014

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