Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Yeni Nesil Bulk-Fill Rezin Kompozitlerin Su Emilimi ve Suda Çözünürlük Düzeylerinin İncelenmesi: in vitro Çalışma
Investigation of Water Absorption and Water Solubility of New Generation Bulk-Fill Resin Composites: in vitro Study
Hatice BULUTa , Nihan GÖNÜLOLa
aOndokuz Mayıs Üniversitesi Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi AD, Samsun, Türkiye
Turkiye Klinikleri J Dental Sci. 2024;30(3):480-8
doi: 10.5336/dentalsci.2024-101419
Article Language: TR
Full Text
ÖZET
 Amaç: Çalışmanın amacı, yeni nesil bulk-fill kompozitlerin distile suda bekletilmesi sonrasında su emilimi ve çözünürlük değerlerinin incelenmesidir. Gereç ve Yöntemler: Çalışmada bir mikrohibrit kompozit (Filtek Z250), bir akışkan kompozit (Filtek Supreme Flowable), iki yüksek viskoziteli bulk-fill kompozit (Tetric Powerfill, Filtek One Bulk-Fill) ve iki düşük viskoziteli bulk-fill kompozit (Tetric Powerflow, Filtek Bulk-Fill Flowable) kullanılarak 104 örnek (8 mm çapx2 mm kalınlık) hazırlandı. Örnekler BluePhase PowerCure polimerizasyon cihazının standart modunda (1.200 mW/cm2 ) 10 sn polimerize edildi. Tetric Powerfill ve Tetric Powerflow kompozitlerinden yeni örnekler hazırlanarak aynı cihazın 3s Powercure modunda (3.050 mW/cm2 ) 3 sn polimerize edilerek 2 grup daha oluşturuldu (n=13). 30. günün sonunda su emilimi, çözünürlük ve kütle değişim yüzdeleri ISO 4049:2009 standardizasyonuna göre hesaplandı. Verilerin analizinde iki yönlü varyans analizi ve Tukey çoklu karşılaştırma testi kullanıldı. Bulgular: Gruplar arasında en düşük su emilimi Tetric Powerflow 10s grubunda görülürken en yüksek su emilimi Filtek One Bulk-Fill grubunda görüldü. Tetric Powerfill ve Tetric Powerflow kompozitlerin 10s ve 3s grupları arasında su emilimi ve çözünürlük değerleri açısından istatistiksel farka rastlanmadı (p>0,05). Tüm kompozit gruplarının kütle değişim yüzdeleri 30. güne kadar artış gösterdi. Sonuç: Tetric Powerfill ve Tetric Powerflow kompozitlerin hem standart modda hem de yüksek ışık gücü modundaki kısa süreli polimerizasyonları (3 sn) su emilim ve çözünürlük açısından dezavantaj oluşturmamıştır.

Anahtar Kelimeler: Bulk-Fill rezin kompozit; su emilimi; suda çözünürlük
ABSTRACT
 Objective: To examine the water sorption and water solubility values of new generation bulk-fill composites after aging in distilled water. Material and Methods: One microhybrid composite (Filtek Z250), one flowable composite (Filtek Supreme Flowable), two high viscosity bulk-fill composites (Tetric Powerfill, Filtek One BulkFill) and two low viscosity bulk-fill composites (Tetric Powerflow, Filtek Bulk-Fill Flowable) were used and 104 samples (8 mm diameterx2 mm thickness) were prepared. The samples were polymerized for 10 seconds using standard mode (1,200 mW/cm2 ) of BluePhase PowerCure polymerization device. Two more groups were prepared from Tetric Powerfill and Tetric Powerflow composites and polymerized for 3 seconds using the 3s Powercure mode (3,050 mW/cm2 ) of the same device (n=13). At the end of the 30th day the levels of water sorption, solubility and mass change percentages were measured according to ISO 4049:2009 standardization. Data were analyzed using two-way ANOVA and post hoc Tukey's test. Results: Tetric Powerflow 10s group exhibited the lowest water sorption values among all tested groups, while the highest water sorption values were observed in Filtek One-Fill group. There was no significant difference in water sorption and solubility values of 10s and 3s groups of Tetric Powerfill and Tetric Powerflow composites (p>0,05). The weight change percentages of all composite groups increased until the 30th day. Conclusion: The polymerization of Tetric Powerfill and Tetric Powerflow composites in both standard mode and short-term high intensity mode (3 seconds) hasn't resulted in any disadvantage in terms of water sorption and solubility.

Keywords: Bulk-Fill resin composite; sorption; water solubility
REFERENCES:
  1. Zhang N, Xie C. Polymerization shrinkage, shrinkage stress, and mechanical evaluation of novel prototype dental composite resin. Dent Mater J. 2020;39(6):1064-71. [Crossref]  [PubMed] 
  2. Rees JS, Jagger DC, Williams DR, Brown G, Duguid W. A reappraisal of the incremental packing technique for light cured composite resins. J Oral Rehabil. 2004;31(1):81-4. [Crossref]  [PubMed] 
  3. Alrahlah A, Silikas N, Watts DC. Post-cure depth of cure of bulk fill dental resin-composites. Dent Mater. 2014;30(2):149-54. [Crossref]  [PubMed] 
  4. El-Damanhoury H, Platt J. Polymerization shrinkage stress kinetics and related properties of bulk-fill resin composites. Oper Dent. 2014;39(4):374-82. [Crossref]  [PubMed] 
  5. Eakle WS, Bastin KG. Dental Materials: Clinical Applications For Dental Assistants And Dental Hygienists. 4th ed. Holland: Elsevier Health Sciences; 2019.
  6. Kowalska A, Sokolowski J, Bociong K. The photoinitiators used in resin based dental composite-a review and future perspectives. Polymers (Basel). 2021;13(3):470. [Crossref]  [PubMed]  [PMC] 
  7. Ilie N, Watts DC. Outcomes of ultra-fast (3 s) photo-cure in a RAFT-modified resin-composite. Dent Mater. 2020;36(4):570-9. [Crossref]  [PubMed] 
  8. Versluis A, Tantbirojn D, Lee MS, Tu LS, DeLong R. Can hygroscopic expansion compensate polymerization shrinkage? Part I. Deformation of restored teeth. Dent Mater. 2011;27(2):126-33. [Crossref]  [PubMed] 
  9. Karaca MK, Kam Hepdeniz O, Esencan Turkaslan B, Gurdal O. The effect of functionalized titanium dioxide nanotube reinforcement on the water sorption and water solubility properties of flowable bulk-fill composite resins. Odontology. 2022;110(2):313-28. Erratum in: Odontology. 2022. [Crossref]  [PubMed] 
  10. Wei YJ, Silikas N, Zhang ZT, Watts DC. Diffusion and concurrent solubility of self-adhering and new resin-matrix composites during water sorption/desorption cycles. Dent Mater. 2011;27(2):197-205. [Crossref]  [PubMed] 
  11. Mortier E, Gerdolle DA, Jacquot B, Panighi MM. Importance of water sorption and solubility studies for couple bonding agent-resin-based filling material. Oper Dent. 2004;29(6):669-76. [PubMed] 
  12. Heintze SD, Zimmerli B. Relevance of in vitro tests of adhesive and composite dental materials, a review in 3 parts. Part 1: Approval requirements and standardized testing of composite materials according to ISO specifications. Schweiz Monatsschr Zahnmed. 2011;121(9):804-16. Dutch, English. [PubMed] 
  13. Albuquerque PP, Moreira AD, Moraes RR, Cavalcante LM, Schneider LF. Color stability, conversion, water sorption and solubility of dental composites formulated with different photoinitiator systems. J Dent. 2013;41 Suppl 3:e67-72. [Crossref]  [PubMed] 
  14. Gusmão GM, De Queiroz TV, Pompeu GF, Menezes Filho PF, da Silva CH. The influence of storage time and pH variation on water sorption by different composite resins. Indian J Dent Res. 2013;24(1):60-5. [Crossref]  [PubMed] 
  15. Carvalho AA, Moreira Fdo C, Fonseca RB, Soares CJ, Franco EB, Souza JB, et al. Effect of light sources and curing mode techniques on sorption, solubility and biaxial flexural strength of a composite resin. J Appl Oral Sci. 2012;20(2):246-52. [Crossref]  [PubMed]  [PMC] 
  16. Rahim TN, Mohamad D, Md Akil H, Ab Rahman I. Water sorption characteristics of restorative dental composites immersed in acidic drinks. Dent Mater. 2012;28(6):e63-70. [Crossref]  [PubMed] 
  17. Almeida GS, Poskus LT, Guimarães JG, da Silva EM. The effect of mouthrinses on salivary sorption, solubility and surface degradation of a nanofilled and a hybrid resin composite. Oper Dent. 2010;35(1):105-11. [Crossref]  [PubMed] 
  18. Ortengren U, Wellendorf H, Karlsson S, Ruyter IE. Water sorption and solubility of dental composites and identification of monomers released in an aqueous environment. J Oral Rehabil. 2001;28(12):1106-15. [Crossref]  [PubMed] 
  19. Yap AU, Tan CH, Chung SM. Wear behavior of new composite restoratives. Oper Dent. 2004;29(3):269-74. [PubMed] 
  20. Mirsasaani SS, Ghomi F, Hemati M, Tavasoli T. Measurement of solubility and water sorption of dental nanocomposites light cured by argon laser. IEEE Trans Nanobioscience. 2013;12(1):41-6. [Crossref]  [PubMed] 
  21. Sevilmiş HH, Bulucu B. Adeziv materyallerin su emilimi özellikleri [Water Sorption Property of Adhesive Materials]. 2007;31(2):16-21. [Link] 
  22. Genç G, Toz T. Rezin kompozitlerin renk stabilitesi ile ilgili bir derleme: Kompozit renklenmelerinin etyolojisi, sınıflandırılması ve tedavisi [A review of the color stability of resin composites: the etiology, classification and the treatment of composite staining]. Ege Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2017;38(2):68-79. [Crossref] 
  23. Sideridou I, Tserki V, Papanastasiou G. Study of water sorption, solubility and modulus of elasticity of light-cured dimethacrylate-based dental resins. Biomaterials. 2003;24(4):655-65. [Crossref]  [PubMed] 
  24. Gorsche C, Griesser M, Gescheidt G, Moszner N, Liska R. β-allyl sulfones as addition-fragmentation chain transfer reagents: A tool for adjusting thermal and mechanical properties of dimethacrylate networks. Macromolecules. 2014;47(21):7327-36. [Crossref] 
  25. Barner-Kowollik C. Handbook of RAFT Polymerization. 1st ed. John Wiley & Sons; 2008. [Crossref] 
  26. Klarić N, Macan M, Par M, Tarle Z, Marović D. Effect of rapid polymerization on water sorption and solubility of bulk-fill composites. Acta Stomatol Croat. 2022;56(3):235-45. [Crossref]  [PubMed]  [PMC] 
  27. Ortengren U, Andersson F, Elgh U, Terselius B, Karlsson S. Influence of pH and storage time on the sorption and solubility behaviour of three composite resin materials. J Dent. 2001;29(1):35-41. [Crossref]  [PubMed] 
  28. Alshali RZ, Salim NA, Satterthwaite JD, Silikas N. Long-term sorption and solubility of bulk-fill and conventional resin-composites in water and artificial saliva. J Dent. 2015;43(12):1511-8. [Crossref]  [PubMed] 
  29. Zankuli MA, Devlin H, Silikas N. Water sorption and solubility of core build-up materials. Dent Mater. 2014;30(12):e324-9. [Crossref]  [PubMed] 
  30. Castro FL, Campos BB, Bruno KF, Reges RV. Temperature and curing time affect composite sorption and solubility. J Appl Oral Sci. 2013;21(2):157-62. [Crossref]  [PubMed]  [PMC] 
  31. Gonçalves L, Filho JD, Guimarães JG, Poskus LT, Silva EM. Solubility, salivary sorption and degree of conversion of dimethacrylate-based polymeric matrixes. J Biomed Mater Res B Appl Biomater. 2008;85(2):320-5. [Crossref]  [PubMed] 
  32. Lopes LG, Jardim Filho Ada V, de Souza JB, Rabelo D, Franco EB, de Freitas GC. Influence of pulse-delay curing on sorption and solubility of a composite resin. J Appl Oral Sci. 2009;17(1):27-31. [Crossref]  [PubMed]  [PMC] 

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