Turkiye Klinikleri Journal of Health Sciences

.: REVIEW
Vitiligo Hastalığında D Vitamininin Rolü Üzerine Geleneksel Bir Derleme
A Traditional Review of the Role of Vitamin D in Vitiligo
Selma FIRATa, Aylin AYAZb
aKırklareli Üniversitesi Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü, Kırklareli, TÜRKİYE
bHacettepe Üniversitesi Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Ankara, TÜRKİYE
Turkiye Klinikleri J Health Sci. 2022;7(1):271-7
doi: 10.5336/healthsci.2021-82088
Article Language: TR
Full Text
ÖZET
 Bir cilt hastalığı olan vitiligo, ciltteki fonksiyonel melanositlerin kaybından kaynaklanan yaygın bir pigment bozukluğu olup, vücudun farklı bölgelerinde tutulmalara ve beyaz leke şeklindeki yamalara neden olmaktadır. Bu durum, hastanın yaşam kalitesini olumsuz etkilemektedir. Vitiligo tedavisinde, medikal ve cerrahi tedavinin yanında terapötik ajanlar kullanılmaktadır. D vitamini de bunlardan biridir. D vitamininin temel fizyolojik fonksiyonu insan vücudunda kalsiyum ile kemik metabolizmasının düzenlenmesinde görev almasıdır. Ayrıca hücre çoğalması, farklılaşması ve bağışıklık sisteminde fonksiyonları bulunmaktadır. D vitamini cilt pigmentasyonundan sorumlu, deride sentezlenen önemli bir hormondur. Bir otoimmün hastalık olan vitiligoda, D vitamini düzeyinin düşüklüğü gözlenmiştir. Yağda çözünen bir vitamin olan D vitamini, antiapoptotik özelliğiyle melanogenez ve kültürlenmiş insan melanositlerinin tirozinaz enziminin miktarını artırdığı belirlenmiş ve melanositler üzerinde büyüme önleyici etkileri bildirilmiştir. Vitamin D, vitiligoya sebep olan çeşitli sitokinlerin ekspresyonunu da azaltmaktadır. Günümüzde vitiligo tedavisinde, fototerapi ve ultraviyole tedavisiyle birlikte D vitamini kullanıldığında önemli sonuçlar elde edilmiştir. Sonuç olarak vitamin D takviyesinin, melanosit kaybını önleyerek vitiligo tedavisinde önemli katkı sağlayabileceği bildirilmiştir. Bu derlemede, D vitamininin cilt pigmentasyonundaki rolü ve vitiligo hastalığıyla ilişkisi incelenmiştir.

Anahtar Kelimeler: Vitiligo; otoimmünite; D vitamini; terapötikler
ABSTRACT
 Vitiligo, a skin disease, is a common pigment disorder caused by the loss of functional melanocytes in the skin, causing retention in different parts of the body and patches in the form of white spots. This situation adversely affects the quality of life of the patient. In addition to medical and surgical treatment, therapeutic agents are used in the treatment of vitiligo. Vitamin D is one of them. The basic physiological function of vitamin D is the role of calcium in the regulation of bone metabolism in the human body. It also has cell proliferation, differentiation and functions in the immune system. Vitamin D is an important hormone synthesized in the skin responsible for skin pigmentation. In vitiligo, an autoimmune disease, low vitamin D levels have been observed. Vitamin D, an oil-soluble vitamin, has been determined to increase the amount of tyrosinase enzyme in melanogenesis and cultured human melanocytes with its antiapoptotic properties and growth inhibitory effects on melanocytes have been reported. Vitamin D also reduces the expression of various cytokines that cause vitiligo. Nowadays, when vitamin D is used together with phototherapy and ultraviolet treatment, important results have been obtained in the treatment of vitiligo. As a result, it has been reported that vitamin D supplementation may contribute to the treatment of vitiligo by preventing melanocyte loss. In this review, the role of vitamin D in skin pigmentation and its relationship with vitiligo disease was investigated.

Keywords: Vitiligo; autoimmunity; vitamin D; therapeutics
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