Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Vitiligo Hastalarında Serum C-Reaktif Protein/Albumin Oranının Değerlendirilmesi: Retrospektif Vaka Kontrol Çalışması
Assessment of the Serum C-Reactive Protein/Albumin Ratio in Patients with Vitiligo: A Retrospective Case-Control Study
Bülent Nuri KALAYCIa
aMalatya Turgut Özal Üniversitesi Tıp Fakültesi, Dermatoloji ABD, Malatya, Türkiye
Turkiye Klinikleri J Dermatol. 2023;33(2):60-6
doi: 10.5336/dermato.2022-94816
Article Language: TR
Full Text
ÖZET
 Amaç: Vitiligo etiyopatogenezinde sistemik inflamasyon önemli rol oynar. Birçok inflamatuar hastalık için serum C-reaktif protein (CRP)/albumin oranı [C-reactive protein/albumin ratio (CAR)] prognostik belirteç olarak bildirilmektedir. Vitiligo hastalarında ve sağlıklı kontrollerde CAR değerinin belirlenerek, vitiligo şiddeti ve aktivitesi ile ilişkisinin araştırılmasını amaçladık. Gereç ve Yöntemler: Hastanemizde vitiligo tanısı konulmuş 78 hasta ile benzer yaş ve cinsiyette 78 sağlıklı kontrol retrospektif olarak çalışmaya alındı. Hastalık şiddetini belirlemek için Vitiligo Alan ve Şiddet İndeksi kullanıldı. Vitiligo Hastalık Aktivite Skoru [Vitiligo Disease Activity Score (VIDA)] baz alınarak, hastalar aktif ve stabil olarak 2 grupta incelendi. Hasta ve kontrol grubu için serum CRP ve serum albumin değerleri oranlanarak CAR değeri hesaplandı. Bulgular: Çalışmadaki 78 hastanın 30'u (%38) erkek, 48'i (%62) kadın; yaş ortalaması 33±8,9 idi. Kontrol grubunun 32'si (%41) erkek, 46'sı (%59) kadın; yaş ortalaması 35,8±9,7 idi (p>0,05). Serum CRP düzeyi hasta grubunda ortalama 0,82±0,44 mg/dL iken, sağlıklı kontrollerde 0,31±0,17 mg/dL olarak bulundu (p=0,001). Ortalama CAR değeri hasta grubunda 0,21±0,12, sağlıklı kontrollerde 0,07±0,04 olarak bulundu (p=0,001). VIDA skoru ile CAR değeri (r=0,54; p<0,01) arasında ve VIDA skoru ile CRP değeri (r=0,47; p<0,01) arasında pozitif korelasyon mevcuttu. CAR için kesme değeri (cut off) %78 sensitivite ve %80 spesifite ile 0,2 idi. Sonuç: CAR değeri, vitiligoda sistemik inflamasyonun ve hastalık aktivitesinin bir göstergesi olabilir.

Anahtar Kelimeler: Vitiligo; C-reaktif protein; albumin; C-reaktif protein/albumin oranı
ABSTRACT
 Objective: Systemic inflammation plays a significant role in the etiopathogenesis of vitiligo. The serum C-reactive protein (CRP)/albumin ratio (CAR) has been reported as an important prognostic marker in many inflammatory diseases. To determine the CAR value in patients with vitiligo and healthy controls and investigate the relationship of this parameter with vitiligo severity and activity. Material and Methods: Seventy-eight patients diagnosed with vitiligo in our hospital and 78 age- and gender-matched healthy controls were retrospectively included in the study. Disease severity was assessed using the Vitiligo Area and Severity Index. The Vitiligo Disease Activity Score (VIDA) was used to determine disease activity. The CAR value was calculated by dividing the serum CRP values by the serum albumin values for the patient and control groups. Results: Of the 78 patients with vitiligo in these study, 30 (38%) were male and 48 (62%) were female, and their mean age was 33±8.9 years. In the healthy controls, 32 (41%) participants were male and 46 (59%) were female, with a mean age of 35.8±9.7 years (p>0.05). The serum CRP level was mean 0.82±0.44 mg/dL in the vitiligo group and 0.31±0.17 mg/dL in the controls (p=0.001). The mean CAR values of the vitiligo was 0.21±0.12 and healthy controls was 0.07±0.04 (p=0.001). A positive correlation was observed between the VIDA score and CAR (r=0.54; p<0.01) and CRP (r=0.47; p<0.01). The CAR cut-off value was calculated as 0.2 with 78% sensitivity and 80% specificity. Conclusion: The CAR value may be indicative of systemic inflammation and disease activity in vitiligo.

Keywords: Vitiligo; C-reactive protein; albumin; C-reactive protein/albumin ratio
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