Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Treatment Efficacy Studies of the Lacrimal Punctum Plug in Blepharitis and Dry Eye Syndromes: Methodological Research, Retrospective Validation Study
Blefarit ve Kuru Göz Sendromunda Lakrimal Punktum Tıkacının Tedavi Etkinlik Çalışmaları: Metodolojik Araştırma, Geriye Dönük Doğrulama Çalışması
Ayhan ÖNALa
aPrivate Physician, Ankara, Türkiye
Turkiye Klinikleri J Ophthalmol. 2024;33(3):147-55
doi: 10.5336/ophthal.2023-100672
Article Language: EN
Full Text
ABSTRACT
 Objective: To examine the most recent literature regarding therapeutic effectiveness studies of lacrimal punctum plugs (PPs) in blepharitis and dry eye syndromes (DES). Material and Methods: This study involves methodological research, Retrospective Validation Studies, and Multivariate Meta-analysis. The data were provided with the PubMed (The National Center for Biotechnology Information, the U.S.), Google Scholar (The Google Co., the U.S.), SCOPUS (The ELSEVIER Co., The Netherlands), WoS (The Clarivate analytics Co., UK & USA), and Google Academic Papers (The Google Co., the U.S.) in between 2012 and 2023. Results: The findings show decreased lubricant dependence, increased tear film consistency, and enhanced patient-reported outcomes. Long-term effectiveness, comparative studies, combination therapy, patient selection, plug design, and monitoring of complications should be the main topics of future research. The combined findings from the studies under consideration shed light on the possible advantages and difficulties connected with this therapeutic strategy. Conclusion: Although the studies that have been evaluated offer insightful information, the variety of plug designs and patient groups need further rigorous randomized controlled trials to establish the broader effectiveness of this treatment approach.

Keywords: Lacrimal punctum plugs; lacrimal PPs; blepharitis and PPs; dry eye syndromes and PPs; DES and lacrimal PPs
ÖZET
 Amaç: Blefarit ve kuru göz sendromlarında (DES) lakrimal punktum tıkaçlarının (PP'ler) terapötik etkinlik çalışmalarına ilişkin en yeni literatürü incelemek. Gereç ve Yöntemler: Bu çalışma metodolojik araştırmayı, Retrospektif Doğrulama Çalışmalarını ve Çok Değişkenli Meta-analizi içermektedir. Veriler 2012 ile 2023 yılları arasındaki PubMed (Ulusal Biyoteknoloji Bilgi Merkezi, ABD), Google Scholar (The Google Co., ABD), SCOPUS (The ELSEVIER Co., Hollanda), WoS (The Clarivate Analytics Co., Birleşik Krallık ve ABD) ve Google Akademik Makaleler (The Google Co., ABD)'den sağlanmıştır. Bulgular: Sonuçlar lubrikan bağımlılığının azaldığını, gözyaşı filmi kıvamının arttığını ve hasta tarafından bildirilen sonuçların arttığını göstermektedir. Uzun vadeli etkinlik, karşılaştırmalı çalışmalar, kombinasyon tedavisi, hasta seçimi, tıkaç tasarımı ve komplikasyonların izlenmesi gelecekteki araştırmaların ana konuları olmalıdır. Bu çalışmalardan elde edilen birleştirilmiş bulgular, bu terapötik stratejiyle bağlantılı olası avantajlara ve zorluklara ışık tutmaktadır. Sonuçlar: Değerlendirilen çalışmalar aydınlatıcı bilgiler sağlamasına rağmen, tıkaç tasarımlarının ve hasta gruplarının çeşitliliği, bu tedavi yaklaşımının daha geniş etkinliğini belirlemek için daha titiz randomize kontrollü çalışmalar gerekmektedir.

Anahtar Kelimeler: Lakrimal punctum tıkaçları; lakrimal PP'ler; blefarit ve PP'ler; kuru göz sendromları ve PP'ler; DES ve lakrimal PP'ler
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