Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
Tranexamic Acid and Bleeding Parameters Among High Tibial Osteotomy Patients: A Systematic Review and Meta-analysis
Yüksek Tibial Osteotomi Hastalarında Traneksamik Asit ve Kanama Parametreleri: Gözden Geçirme ve Meta-analiz
Ferdian RIZALIANSYAHa, Farahdina FARAHDINAb, Justika Usmadhani AULYAc, Jonny Karunia FAJARd
aDepartment of General Medicine, Universitas Airlangga Faculty of Medicine, Surabaya, INDONESIA
bDepartment of General Medicine, Universitas Brawijaya Faculty of Medicine, Malang, INDONESIA
cDepartment of General Medicine, Universitas Sumatra Utara Faculty of Medicine, Medan, INDONESIA
dDepartment of Internal Medicine, Universitas Brawijaya Faculty of Medicine, Brawijaya Internal Medicine Research Center, Malang, INDONESIA
Turkiye Klinikleri J Med Sci. 2021;41(1):15-21
doi: 10.5336/medsci.2020-80210
Article Language: EN
Full Text
ABSTRACT
 Objective: To clarify and elucidate the real correlation between tranexamic acid administration and post-operative bleeding parameters in high tibial osteotomy (HTO) patients. Material and Methods: Articles published in PubMed, Embase, and Cochrane Library were searched and included in our analysis under the eligibility criteria. Information related to bleeding parameters among HTO patients treated with tranexamic acid and placebo was collected and analyzed using random or fixed-effect models. Results: A total of five papers were included in our study. Our pooled calculations found that tranexamic acid was associated with reduced bleeding parameters in HTO patients including drainage volume on the first day (mean diff=1.47 [95% CI=0.33-2.65], p=0.0120), hemoglobin decline on the second day (mean diff=0.79 [95% CI=0.59-1.00], p=0.0000), and total blood loss (mean diff=2.25 [95% CI=0.59-3.91], p=0.0080) compared to control group. However, we failed to elucidate the correlation between tranexamic acid administration and hemoglobin decline on the first day among patients with HTO. Conclusion: Tranexamic acid is associated with reduced drainage volume on the first day, hemoglobin decline on the second day, and total blood loss among HTO patients.

Keywords: High tibial osteotomy; tranexamic acid; bleeding
ÖZET
 Amaç: Yüksek tibial osteotomi (YTO) hastalarında traneksamik asit uygulaması ile ameliyat sonrası kanama parametreleri arasındaki gerçek korelasyonu netleştirmek ve aydınlatmak. Gereç ve Yöntemler: PubMed, Embase ve Cochrane Kütüphanesinde yayınlanan makaleler taranmış ve uygunluk kriterleri kapsamında araştırmamıza dahil edilmiştir. Traneksamik asit ve plasebo ile tedavi edilen YTO hastalarında kanama parametreleriyle ilgili bilgiler toplanmış ve rastgele veya sabit etkili modeller kullanılarak analiz edilmiştir. Bulgular: Çalışmamıza toplam beş makale dahil edilmiştir. Havuzlanmış hesaplamalarımıza göre traneksamik asidin kontrol grubuna göre YTO hastalarında kanama parametrelerinde azalma ile ilişkili olduğu bulunmuştur; ilk gündeki drenaj hacmi (ortalama fark = 1.47 [% 95 CI = 0.33-2.65], p = 0.0120), ikinci gün hemoglobin düşüşü (ortalama fark = 0.79 [% 95 CI = 0.59-1.00], p = 0.0000) ve toplam kan kaybı (ortalama fark = 2.25 [95% CI = 0.59-3.91], p = 0.0080). Bununla birlikte, YTO'lu hastalarda traneksamik asit uygulaması ile hemoglobinde ilk günkü düşüş arasındaki ilişkiyi aydınlatamadık. Sonuç: Traneksamik asit YTO hastalarında ilk gün azalmış drenaj hacmi, ikinci gün hemoglobin azalması ve toplam kan kaybı ile ilişkilidir.

Anahtar Kelimeler: Yüksek tibial osteotomi; traneksamik asit; kanama
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