Journal of Literature Pharmacy Sciences

Probiyotiklerin Toksikolojik Açıdan Değerlendirilmesi
Toxicological Evaluation of Probiotics
Ebru ÖZMENa, Suna SABUNCUOĞLUa
aHacettepe Üniversitesi Eczacılık Fakültesi, Farmasötik Toksikoloji ABD, Ankara, TÜRKİYE
J Lit Pharm Sci. 2020;9(1):42-9
doi: 10.5336/pharmsci.2019-71103
Article Language: TR
Full Text
ÖZET
 İnsan vücudunda kendi hücrelerinden çok daha fazla sayıda bakteri yaşamaktadır. Bakterilerin vücutta oluşturduğu bu bakteri topluluğu mikrobiyota olarak ifade edilmektedir. Genel kullanım alanlarına bağlı olarak probiyotikler, kalitatif veya kantitatif olarak bağırsak mikroflorasını değiştirebilen, bağışıklık sistemini destekleyerek yararlı etkilerini tetikleyen, canlılar tarafından tüketilen canlı mikroorganizmalar şeklinde tanımlanmaktadır. Probiyotiklerin yararlı etkileri olduğu bilinmekle beraber, bu preparatların güvenli kullanımı üzerine yeterince çalışma bulunmamaktadır. Bu durum, kontrolsüz bir şekilde bu kadar yaygın olarak kullanılan probiyotiklerin güvenliliklerinin de sorgulanmasını gerektirmektedir. Bu derlemede, tüm dünyada çok popüler olan ve yeterli miktarda verildiğinde hastaya yarar sağlayan canlı mikroorganizmalar olarak tanımlanan probiyotiklerin kullanımının toksikolojik açıdan güvenirliliği ve risk analizi değerlendirilmiştir.

Anahtar Kelimeler: Mikrobiyota; probiyotik; probiyotik güvenlik ve toksisitesi
ABSTRACT
 The number of bacteria in the human body is much higher than their own cell count. This bacterium formed by bacteria in the body is defined as microbiota. Depending on their general field of use, probiotics are defined as living microorganisms that can either qualitatively or quantitatively alter intestinal microflora, support the immune system and trigger beneficial effects. These bacteria have health effects as well as the drugs used and the additional probiotics taken have an effect on the microbiota. Probiotics are known to have beneficial effects, but there is still insufficient study on the safe use of these preparations. This requires an uncontrolled questioning of the safety of such widely used probiotics. In this review, toxicological safety and risk analysis of probiotics identified as living microorganisms, which are very popular all over the world and given sufficient amounts, are evaluated.

Keywords: Microbiota; probiotic; probiotic safety and toxicity
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