Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
The Relationship Between Quality of Life Questionnaires and Retinal Nerve Fiber Thickness: A Cross-Sectional Study
Yaşam Kalitesi Anketi ile Retina Sinir Lifi Kalınlığı Arasındaki İlişki: Kesitsel Araştırma
Yücel ÖZTÜRKa , Alev ÖZÇELİK KÖSEa , Aysun YÜCEL GENÇOĞLUa , Hatice TEKCANa , Okşan ALPOĞANa, Yasemin ÜNa , Serhat İMAMOĞLUa
aDepartment of Ophthalmology, University of Health Sciences Haydarpaşa Numune Training and Research Hospital, İstanbul, Türkiye
Turkiye Klinikleri J Ophthalmol. 2023;32(4):217-24
doi: 10.5336/ophthal.2023-96788
Article Language: EN
Full Text
ABSTRACT
 Objective: The purpose of this study was to determine the association between vision-related quality of life (QoL) and retinal nerve fiber layer (RNFL) loss. Material and Methods: This cross-sectional study included 92 patients diagnosed with primary open angle glaucoma. Visual acuity (VA), visual field (VF) and RNFL were assessed. The patients were divided into 3 groups according to the glaucoma damage in the VF as mild, moderate and severe. Patient-reported QoL was determined using the Glaucoma Quality of Life-15 (GQL-15) and the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). Results: The mean age of the patients was 61.38±12.58 years and the mean duration of glaucoma was 7.91±4.74 years. There was no statistically significant difference between the groups in terms of age, gender and diagnosis time. Patients with Stage 3 glaucoma had thinner RNFL in the better eye and worse VA in the better and worse eyes compared to patients with Stage 1 glaucoma. There were significant differences in terms of GQL-15 and NEI VFQ-25 scores between the mild and severe patients. The thickness of the RNFL differed significantly between the 3 groups. Correlation analysis revealed that the general health, general vision, mental health and peripheral vision subdomains of the NEI VFQ-25 were moderately correlated with RNFL thickness. The total and subdomain scores of the GQL-15 were not correlated with RNFL thickness. Conclusion: In patients with glaucoma, RNFL thickness loss is associated with NEI VFQ-25 scoring, but not with GQL-15 scores.

Keywords: Glaucoma; National Eye Institute Visual Function Questionnaire-25; Glaucoma Quality of Life-15; retinal nerve fiber layer
ÖZET
 Amaç: Bu çalışmanın amacı, görme ile ilişkili yaşam kalitesi [quality of life (QoL)] anketi ile retina sinir lifi tabakası (RSLT) kaybı arasındaki ilişkiyi belirlemektir. Gereç ve Yöntemler: Bu kesitsel çalışmaya primer açık açılı glokom tanısı konan 92 hasta dâhil edildi. Görme keskinliği, görme alanı ve RSLT değerlendirildi. Hastalar görme alanındaki glokom hasarına göre hafif, orta ve şiddetli olarak 3 gruba ayrıldı. Hasta tarafından bildirilen QoL, Glokom Yaşam Kalitesi-15 [Glaucoma Quality of Life-15 (GQL-15)] ve 25 maddelik Ulusal Göz Enstitüsü Görsel İşlev Anketi [National Eye Institute Visual Function Questionnaire (NEI VFQ-25)] ile belirlendi. Bulgular: Ortalama yaş 61,38±12,58 ve ortalama glokom süresi 7,91±4,74 yıldı. Gruplar arasında yaş, cinsiyet ve tanı süresi açısından istatistiksel olarak anlamlı fark yoktu. Evre 3 glokomlu hastalar, Evre 1 glokomlu hastalara kıyasla daha iyi gözde daha ince RSLT'ye, daha iyi ve daha kötü gözlerde daha kötü görme keskinliğine sahipti. Hafif ve şiddetli hastalar arasında GQL-15 ve NEI VFQ-25 skorları açısından anlamlı fark vardı. RSLT'nin kalınlığı 3 grup arasında önemli ölçüde farklılık gösterdi. Korelasyon analizi, NEI VFQ-25'in genel sağlık, genel görme, zihinsel sağlık ve periferik görme alt alanlarının RSLT kalınlığı ile orta derecede ilişkili olduğunu ortaya koydu. GQL-15'in toplam ve alt alan puanları RSLT kalınlığı ile korele değildi. Sonuç: Glokomlu hastalarda RSLT kalınlık kaybı NEI VFQ-25 skorlaması ile ilişkili iken, GQL-15 skorları ile ilişkili değildir.

Anahtar Kelimeler: Glokom; Ulusal Göz Enstitüsü Görsel İşlev Anketi-25; Glokom Yaşam Kalitesi-15; retina sinir lifi tabakası
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