Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
The Recent Studies on the Prevention of Hereditary Transmission in Age-Related Macular Degeneration: Methodological Research, Retrospective Validation Study
Yaşa Bağlı Makula Dejeneresansında Genetik Geçişten Korunmak ile İlgili Son Çalışmalar: Metodolojik Araştırma, Retrospektif Doğrulama Çalışması
Ayhan ÖNALa
aPrivate Physician, İstanbul, Türkiye
Turkiye Klinikleri J Ophthalmol. 2024;33(2):94-101
doi: 10.5336/ophthal.2023-100690
Article Language: EN
Full Text
ABSTRACT
 Objective: This study focused on the prevention of hereditary transmission in senile macular degeneration and conducted a comprehensive evaluation of recent research publications released between 2019 and 2023. Material and Methods: Medical Subject Headings terms and keywords associated with genetic transmission, macular degeneration therapies, and preventative measures were applied to search PubMed and Google Scholar. The review's objectives were to uncover pertinent literature, describe distinctive qualities, and evaluate findings concerning hereditary transmission prevention in Türkiye. Results: This study includes methodological research, retrospective validation studies, and the data were published by PubMed, Google Scholar, SCOPUS, WoS, and Google Academic research between 2019 and 2023. Studies highlighting this prevention were covered by the inclusion criteria, while unrelated or non-English studies were excluded by the exclusion criteria. 18 papers were left, and sourced following a thorough search technique produced 107 papers from databases. Conclusion: This section highlighted a few recent research that covered several facets of preventing age-related macular degeneration (AMD). The complex character of AMD was underlined, highlighting the significance of genetics, environmental factors, oxidative stress, diet, mitochondrial health in the prevention and treatment of diseases that could result in vision loss. Besides that, treatment possibilities, such as anti-vascular endothelial growth factor therapy and induced pluripotent stem cells-based methods, were all discussed in the research.

Keywords: Senile macular degeneration; hereditary transmission; age-related macular degeneration
ÖZET
 Amaç: Bu çalışma, senil makula dejenerasyonunda kalıtsal bulaşının önlenmesine odaklanmış ve 2019-2023 yılları arasında yayımlanan son araştırma yayınlarının kapsamlı bir değerlendirmesi yapılmıştır. Gereç ve Yöntemler: Genetik geçiş, makula dejenerasyonu tedavileri ve önleyici tedbirlerle ilişkili Tıbbi Konu Başlıkları terimleri ve anahtar kelimeleri ele alınmış, Pub-Med ve Google Akademik'te arama yapmak için kullanılmıştır. İncelemenin amacı; ilgili literatürü ortaya çıkarmak, ayırt edici özellikleri tanımlamak ve Türkiye'de kalıtsal transmisyonun önlenmesine yönelik bulguları değerlendirmektir. Bulgular: Bu çalışma, metodolojik araştırmaları, geriye dönük doğrulama çalışmalarını içermekte olup, veriler 2019-2023 yılları arasında PubMed, Google Akademik, SCOPUS, WoS ve Google Akademik araştırmaları tarafından yayınlanmıştır. Bu önlemeyi vurgulayan çalışmalar dâhil edilme kriterleri kapsamına alınırken, ilgisiz veya İngilizce olmayan çalışmalar hariç tutma kriterlerine tabi tutuldu. Kapsamlı bir arama tekniğinin ardından veri tabanlarındaki 107 makaleden 18 tanesi kaldı ve kaynak alındı. Sonuç: Bu bölümde yaşa bağlı makula dejenerasyonunu (YBMD) önlemenin çeşitli yönlerini kapsayan birkaç yeni araştırma vurgulandı. YBMD'nin karmaşık karakterine dikkat çekilerek, görme kaybına neden olabilecek hastalıkların önlenmesinde ve tedavisinde genetiğin, çevresel faktörlerin, oksidatif stresin, diyetin, mitokondri sağlığının önemi vurgulandı. Ayrıca araştırmada antivasküler endotelyal büyüme faktörü tedavisi ve indüklenmiş pluripotent kök hücrelere dayalı metotlar da tartışıldı.

Anahtar Kelimeler: Senil makula dejenerasyonu; kalıtsal geçiş; yaşa bağlı makula dejenerasyonu
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