Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
The Prevalence of New Positive Patch Test Reactions at 168 Hours: A Retrospective Cross-Sectional Study
Yama Testinde 168. Saatte Ortaya Çıkan Yeni Pozitifliklerin Prevalansı: Retrospektif Kesitsel Bir Çalışma
Münevver GÜVENa , Kübra EREN BOZDAĞb , Neslihan ŞENDURc
aDepartment of Dermatology, Aydın Adnan Menderes University Faculty of Medicine, Aydın, Türkiye
bClinic of Dermatology, Kent Medical Center, İzmir, Türkiye
cClinic of Dermatology, Medicana International İzmir Hospital, İzmir, Türkiye
Turkiye Klinikleri J Dermatol. 2023;33(1):1-6
doi: 10.5336/dermato.2022-90508
Article Language: EN
Full Text
ABSTRACT
 Objective: Some clinics interpret patch test results 48 hours after application and an additional reading is performed at 72 or 96 hours. Reports in the literature describe delayed positive reaction to some allergens in patients who underwent patch testing for suspected allergic contact dermatitis. However, an additional late reading may be neglected in some clinics. In this study we aimed to identify allergens with delayed positive patch test reactions and to determine the relevance of an additional day 7 (168 hours) patch test reading. Material and Methods: The data of 101 patients who underwent patch testing for suspected allergic contact dermatitis between January 2015 and July 2016 were analyzed retrospectively. Demographic data and patch test results of the patients were evaluated. Allergens without a positive reaction at the 48th and 96th hours but with a positive reaction at the 168th hour were considered as delayed positive patch test reaction. Results: Sixty-four (63.3%) of 101 patients had positive reactions to at least 1 allergen. A total of 125 positive reactions were detected. Of the 125 positive reactions, 85 (68%) were positive at 48 hours reading and 31 (24.8%) turned positive at 96 hours evaluation. Nine (7.2%) of 125 positive reactions were late reactions that turned positive at 168 hours. Nickel sulfate, gold sodium thiosulfate, Cl+Me-isothiazolinone, formaldehyde, tixocortol pivalate and hydrocortisone-17-butyrate, and fragrance mix were detected as allergens causing late positive reactions. Conclusion: We think that late reading at the 168th hour should not be neglected.

Keywords: Allergens; allergic contact dermatitis; patch tests
ÖZET
 Amaç: Bazı kliniklerde yama testi sonuçları, uygulamadan 48 saat sonra değerlendirilir ve 72 veya 96 saatlerde ek bir değerlendirme yapılır. Literatürde, alerjik kontakt dermatit şüphesiyle yama testi yapılan hastalarda bazı alerjenlere karşı gecikmiş pozitif reaksiyonlar bildirilmektedir. Ancak bazı kliniklerde, fazladan bir geç okuma ihmal edilebilmektedir. Bu çalışmada, gecikmiş pozitif yama testi reaksiyonları olan alerjenleri tanımlamayı ve fazladan bir 7. gün (168 saat) yama testi okumasının yeni pozitif sonuçları saptamaya katkısını belirlemeyi amaçladık. Gereç ve Yöntemler: Ocak 2015-Temmuz 2016 tarihleri arasında, alerjik kontakt dermatit şüphesiyle yama testi yapılan 101 hastaların verileri retrospektif olarak değerlendirildi. Hastaların demografik verileri ve yama testi sonuçları incelendi. Kırk sekiz ve 96. saatte pozitif reaksiyon göstermeyip, 168. saatte pozitif reaksiyon veren alerjenler gecikmiş pozitif yama testi reaksiyonu olarak değerlendirildi. Bulgular: Yüz bir hastanın 64'ünde (%63,3) 1 veya birden fazla alerjene karşı pozitif reaksiyon görüldü. Altmış dört hastada toplam 125 pozitif reaksiyon tespit edildi. Saptanan 125 pozitif reaksiyonun 85'inin (%68) 48. saat değerlendirmesinde, 31'inin (%24,8) 96. saatte yapılan değerlendirmede pozitifleştiği görüldü. Dokuz (%7,2) pozitif reaksiyon ise 48 ve 96. saatlerde negatif olmasına karşın 168. saatte pozitifleşen geç reaksiyonlardı. Nikel sülfat, altın sodyum tiyosülfat, Cl+Me-izotiazolinon, formaldehit, tiksokortol pivalat, hidrokortizon17-butirat ve parfüm karışımı geç pozitif reaksiyonlara neden olan alerjenler olarak tespit edildi. Sonuç: Yüz altmış sekizinci saatte yapılacak geç okumanın ihmal edilmemesi gerektiğini düşünüyoruz.

Anahtar Kelimeler: Alerjenler; alerjik kontakt dermatit; yama testi
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