Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
The Evaluation of Neutrophil-to-Lymphocyte Ratio as a Novel Marker in Patients with Pterygium
Pterjiumlu Hastalarda Bir Belirteç Olarak Nötrofil/Lenfosit Oranının Değerlendirilmesi
Cemile ÜÇGÜL ATILGANa, Pınar KÖSEKAHYAa, Kemal TEKİNa, Selam Yekta ŞENDÜLc, Mehtap ÇAĞLAYANb, Yasin Şakir GÖKERa, Mustafa KOÇa
aAnkara Ulucanlar Eye Training and Research Hospital, Clinic of Ophthalmology, Ankara, TURKEY
bŞişli Hamidiye Etfal Training and Research Hospital, Clinic of Ophthalmology, İstanbul, TURKEY
cGazi Yaşargil Training and Research Hospital, Clinic of Ophthalmology, Diyarbakır, TURKEY
Turkiye Klinikleri J Ophthalmol. 2020;29(1):52-6
doi: 10.5336/ophthal.2019-65942
Article Language: EN
Full Text
ABSTRACT
 Objective: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as an indicator of inflammation in patients with pterygium and to compare data with those of healthy subjects. Material and Methods: Two hundred patients who underwent pterygium surgery (study group) and 200 age and sex matched subjects who underwent strabismus surgery in our clinic (control group) were included in this study. Patients with any ocular and systemic infection history and previously undergoing surgery for pterygia and recurrent pterygia were excluded from the study. Neutrophil and lymphocyte counts of all participants were recorded from all blood samples taken before surgery retrospectively. The NLR was calculated by dividing the neutrophil counts by the lymphocyte counts and compared between groups. Normality of data was analyzed with the Kolmogorov-Smirnov test. An independent t-test was used to compare the variables between the study and control groups. Results: The mean age was 52.61±13.35 and 51.86±14.42 years in the study and control groups, respectively (p=0.58). The neutrophil count was 4.18±1.28 in study group and 4.17±1.37 in control group. The lymphocyte count was 2.11±0.55 in study group and 2.17±0.72 in control group. There was no significant difference between groups in terms of neutrophil, lymphocyte counts and NLR (p=0.91, p=0.36, p=0.54 respectively). Conclusion: In our study, the NLR seems not to be an independent predictor of pterygium disease.

Keywords: Biomarkers; lymphocyte, neutrophil; pterygium
ÖZET
 Amaç: Pterjiumlu hastalarda inflamasyonun bir belirteci olarak Nötrofil-Lenfosit oranını değerlendirmek ve sağlıklı bireylerin nötrofil-lenfosit oranlarıyla karşılaştırmak. Gereç ve Yöntemler: Kliniğimizde primer pterjium cerrahisi geçiren 200 hasta (çalışma grubu) ile yaş ve cinsiyet açısından çalışma grubu ile uyumlu şaşılık cerrahisi geçiren 200 hasta (kontrol grubu) çalışmaya dahil edildi. Herhangi bir oküler ve sistemik enfeksiyonu olan, daha önce pterjium cerrahisi geçiren ya da nüks pterjiumu olan hastalar çalışma dışı bırakıldı. Bütün katılımcıların nötrofil ve lenfosit değerleri cerrahi öncesi alınan rutin kan örneklerinden retrospektif olarak kaydedildi. Nötrofil-lenfosit oranı, nötrofil sayısının lenfosit sayısına bölünmesi ile hesaplandı. Tüm değerler çalışma ve kontrol grubu arasında kıyaslandı. Çalışmada hastaların dağılımının normal olup olmadığının değerlendirilmesi için Kolmogorov-Smirnov testi, gruplar arası değişkenleri değerlendirmek için ise bağımsız t-test kullanıldı. Bulgular: Ortalama yaş, çalışma ve kontrol grubunda sırasıyla 52,61±13,35 ve 51,86±14,42 yıldı (p=0,58). Nötrofil sayısı çalışma grubunda 4,18±1,28 ve kontrol grubunda 4,17±1,37 idi. Lenfosit sayısı ise çalışma grubunda 2,11±0,55 ve kontrol grubunda 2,17±0,72 olarak saptandı. Nötrofil, lenfosit sayısı ve nötrofil-lenfosit oranı açısından çalışma ve kontrol grubu arasında anlamlı fark yoktu (sırasıyla p=0,91, p=0,36, ve p=0,54). Sonuç: Çalışmamızda, nötrofil-lenfosit oranının pterjium hastalığının bağımsız bir belirteci olmadığı gösterilmiştir.

Anahtar Kelimeler: Belirteç; lenfosit; nötrofil; pterjium
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