Journal of Traditional Medical Complementary Therapies

.: ORIGINAL RESEARCH
The Effect of Curcumin on Some Plasma Cytokine Levels in Experimentally-Induced Diabetic Rats
Diyabet Oluşturulan Ratlarda Kurkuminin Bazı Plazma Sitokin Düzeyleri Üzerine Etkisi
Ülkü SAYGILIa, Nurcan DÖNMEZb
aDepartment of Health Care Services, Selçuk University Vocational School of Health Services, Konya, TURKEY
bDepartment of Physiology, Selçuk University Faculty of Veterinary Medicine, Konya, TURKEY
J Tradit Complem Med. 2021;4(1):57-64
doi: 10.5336/jtracom.2020-79086
Article Language: EN
Full Text
ABSTRACT
 Objective: The aim of this study was to determine the effect of curcumin on some plasma cytokines and insulin levels in diabetes mellitus, which has negative effects on many acute and chronic systems in humans and animals. Material and Methods: In the study, thirty adult male Wistar albino rats with similar live weights were used. The subjects used in the study were divided into four groups including Control (K), Diabetes (D), Curcumin (C), and Diabetes+Curcumin (DC). At the end of the experiment, interleukin-6 (IL-6), IL-10, insulin, tumor necrosis factor alpha (TNF-α), and C-reactive protein (CRP) levels in the blood samples taken from the subjects in the groups were determined. Results: IL-6 level was determined to increase significantly in experimentally induced diabetic rats compared to the other three groups (p<0.05). The IL-6 level in the C group was found to be similar to that in the K group whereas it was observed that the IL-6 level was significantly lower in the DC group, in which C was supplemented for the experimentally induced diabetic rats, than in the D group, and approached to the levels obtained in the K and C groups (p<0.05). The CRP level was significantly higher in the D group compared to the other three groups whereas the insulin level was prominently lower (p<0.05). In this study, it was observed that there was a positive and strong relationship between IL-6 and TNF and CRP, and a moderately strong and negative relationship with insulin Conclusion: In conclusion, it was seen that curcumin application does not cause a negative impact on healthy rats and that it is beneficial in reducing the negative effects of diabetes in streptozotocin-induced diabetic rats.

Keywords: Diabetes mellitus; cytokine; curcumin; insulin; streptozotocin
ÖZET
 Amaç: Bu çalışmanın amacı; insan ve hayvanlarda akut ve kronik çok sayıda sistem üzerine olumsuz etkileri olan diabetes ellitusta, kurkumin verilmesinin bazı plazma sitokinleri ve insülin düzeyine etkisinin belirlemektir. Gereç ve Yöntemler: Çalışmada, canlı ağırlıkları birbirine yakın 30 adet yetişkin erkek Wistar Albino sıçan kullanıldı. Denemede kullanılan denekler Kontrol (K), Diyabet (D), Kurkumin (C) ve Diyabet+Kurkumin (DC) olmak üzere 4 gruba ayrıldı. Araştırmada, deneme sonunda gruplardaki deneklerden alınan kan örneklerinde interlökin-6 (IL-6), IL-10, insülin, tümör nekroz faktör alfa (TNF-α), C-reaktif protein (CRP) düzeyleri belirlendi. Bulgular: IL-6 düzeyinin diyabet oluşturulan sıçanlarda diğer 3 gruba göre önemli (p<0,05) oranda arttığı belirlendi. Kurkumin uygulanan grupta belirlenen IL-6 düzeyi kontrole benzerken, diyabet oluşturulduktan sonra C takviyesi yapılan DC grubunda ise IL-6 düzeyinin D grubuna göre önemli oranda düşük olduğu, K ve C gruplarından elde edilen düzeylere ise yaklaştığı gözlendi (p<0,05). IL-10 düzeyinin C grubunda D grubuna kıyasla daha yüksek olduğu, D grubuna kurkumin takviyesinden sonra DC grubunda da IL-10 seviyesinin önemli (p<0,05) oranda arttığı belirlendi. D grubunda CRP seviyesi diğer 3 gruba göre anlamlı bir şekilde yüksek iken insülin düzeyi ise belirgin bir şekilde düşük olarak belirlendi (p<0,05). Bu çalışmada, IL-6 ile TNF ve CRP arasında pozitif ve güçlü bir ilişki olduğu, insülin ile orta derecede güçlü ve negatif bir ilişki olduğu görülmüştür. Sonuç: Streptozotosin ile deneysel diyabet oluşturulan sıçanlarda kurkumin uygulaması sağlıklı sıçanlarda olumsuz bir etki oluşturmamasının yanı sıra diyabette de meydana gelen olumsuz etkileri hafifletmesi bakımından yararlı olduğu görülmektedir.

Anahtar Kelimeler: Diabetes mellitus; sitokin; kurkumin; insülin; streptozotosin
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