Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
The Comparison of Diphenylcyclopropenone and Nd:YAG in the Treatment of Palmar Verrucae
Palmar Siğillerin Tedavisinde Difenilsiklopropenon ve Nd:YAG Tedavilerinin Karşılaştırılması
Özge AŞKINa, Defne ÖZKOCAa, Tuğba Kevser ÜSTÜNBAŞ UZUNÇAKMAKa, Zekayi KUTLUBAYa, Burhan ENGİNa, Server SERDAROĞLUa
aDepartment of Dermatology, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, TURKEY
Turkiye Klinikleri J Dermatol. 2021;31(3):168-73
doi: 10.5336/dermato.2021-81991
Article Language: EN
Full Text
ABSTRACT
 Objective: Palmar verrucae are often recalcitrant to treatment. Diphenylcyclopropenone (DPCP) and Nd:YAG laser are treatment modalities that may be used in cases which are resistant to conventional treatment modalities. The aim of this study is to compare the treatment efficacies and safety of DPCP and Nd:YAG laser in the treatment of palmar verrucae. Material and Methods: A total of 30 patients with single or multiple palmar verrucae were divided into two equal groups: DPCP group and the Nd:YAG group with 15 patients in each. Informed consent of each patient was taken before treatment. Pretreatment photos of each patient were taken. The age, gender, location and number of lesions of each patient were noted. One group received monthly Nd:YAG treatments and the other group received weekly DPCP treatments until complete remission. Results: The mean number of sessions required for remission was 1.6 in the Nd:YAG group and 4 in the DPCP group. Nd:YAG treatment requires a statistically significantly lower number of treatment sessions compared to DPCP treatment (p<0.05). The mean treatment duration was 6.4 weeks for the Nd:YAG group and 4 weeks for the DPCP group. A statistically significant difference was found between the two groups in terms of treatment duration the patients achieved complete remission in the DPCP group faster than the Nd:YAG group (p=0.005). Conclusion: Our study has shown that DPCP is a faster modality than Nd:YAG in the treatment of palmar verrucae. On the other hand, Nd:YAG is more effective per treatment session and therefore requires less hospital visits than Nd:YAG. The treatment efficacy was independent of the patient's age and number of lesions. DPCP was better tolerated than Nd:YAG.

Keywords: Diphenylcyclopropenone; Nd:YAG; palmar verrucae
ÖZET
 Amaç: Palmar siğiller sıklıkla tedaviye dirençlidirler. Difenilsiklopropenon (DPCP) ve Nd:YAG lazer, tedaviye dirençli siğil hastalarında kullanılabilen yöntemlerdir. Bu çalışmadaki amacımız, palmar siğillerin tedavisinde DPCP ve Nd:YAG tedavilerini karşılaştırmaktır. Gereç ve Yöntemler: Çalışmamıza palmar bölgede siğilleri olan toplam 30 hasta dâhil edilip, 2 eşit gruba randomize edildi: 1. gruba DPCP tedavisi verilirken, 2. gruba Nd:YAG tedavisi verildi. Hastalardan tedavi öncesi onam alındı ve fotoğrafları çekildi. Her hastanın yaşı, cinsiyeti, lezyon sayısı ve lokalizasyonu not edildi. Hastalara, tam yanıt elde edene kadar, Nd:YAG tedavisi aylık, DPCP tedavisi de haftalık olarak verildi. Bulgular: Remisyon için gereken seans sayısının ortalaması Nd:YAG grubu için 1,6, DPCP grubu için 4 idi. Nd:YAG grubu istatistiksel olarak daha az seans gerektirmektedir (p<0,05). Nd:YAG grubu için gereken ortalama tedavi süresi 6,4 hafta iken, bu süre DPCP için 4 haftadır. DPCP ile daha hızlı remisyon elde edilmektedir (p=0,005). İki grup arasında tedavi süresi açısından istatistiksel olarak anlamlı fark bulunmuştur: DPCP grubundaki hastalarda Nd: YAG grubuna göre daha hızlı tam remisyon elde edilmiştir. Sonuç: Çalışmamızda, palmar siğillerin tedavisinde DPCP'nin Nd:YAG'ye göre daha hızlı bir metod olduğunu, buna karşılık Nd:YAG'nin etkinliği seans başına daha fazla olup, daha az hastane ziyareti gerektirdiğini gösterdik. Tedavi etkinliği, hastanın yaşından ve lezyon sayısından bağımsızdır. DPCP, Nd:YAG'ye göre daha iyi tolere edilebilmektedir.

Anahtar Kelimeler: Difenilsiklopropenon; Nd:YAG; palmar siğil
REFERENCES:
  1. Sterling JC, Handfield-Jones S, Hudson PM; British Association of Dermatologists. Guidelines for the management of cutaneous warts. Br J Dermatol. 2001;144(1):4-11. [Crossref]  [PubMed] 
  2. Park JY, Park BW, Cho EB, Park EJ, Kim KH, Kim KJ. Clinical efficacy of diphenylcyclopropenone immunotherapy as monotherapy for multiple viral warts. J Cutan Med Surg. 2018;22(3):285-9. [Crossref]  [PubMed] 
  3. Suh DW, Lew BL, Sim WY. Investigations of the efficacy of diphenylcyclopropenone immunotherapy for the treatment of warts. Int J Dermatol. 2014;53(12):e567-71. [Crossref]  [PubMed] 
  4. Choi Y, Kim DH, Jin SY, Lee AY, Lee SH. Topical immunotherapy with diphenylcyclopropenone is effective and preferred in the treatment of periungual warts. Ann Dermatol. 2013;25:434-9. [Crossref]  [PubMed]  [PMC] 
  5. Goldberg DJ, Beckford AN, Mourin A. Verruca vulgaris: novel treatment with a 1064 nm Nd:YAG laser. J Cosmet Laser Ther. 2015;17(2):116-9. [Crossref]  [PubMed] 
  6. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Suga Y. Long-pulsed 1064-nm neodymium:yttrium-aluminum-garnet laser treatment for refractory warts on hands and feet. J Dermatol. 2014;41(3):252-7. [Crossref]  [PubMed] 
  7. El-Mohamady Ael-S, Mearag I, El-Khalawany M, Elshahed A, Shokeir H, Mahmoud A. Pulsed dye laser versus Nd:YAG laser in the treatment of plantar warts: a comparative study. Lasers Med Sci. 2014;29(3):1111-6. [Crossref]  [PubMed] 
  8. Han TY, Lee JH, Lee CK, Ahn JY, Seo SJ, Hong CK. Long-pulsed Nd:YAG laser treatment of warts: report on a series of 369 cases. J Korean Med Sci. 2009;24:889-93. [Crossref]  [PubMed]  [PMC] 
  9. Zorman A, Koron N. Wart removal without anesthesia using long-pulse 1064-nm Nd:YAG laser. J Cosmet Dermatol. 2021;20(2):506-12. [Crossref]  [PubMed]  [PMC] 
  10. Hsu VM, Aldahan AS, Tsatalis JP, Perper M, Nouri K. Efficacy of Nd:YAG laser therapy for the treatment of verrucae: a literature review. Lasers Med Sci. 2017;32(5):1207-11. [Crossref]  [PubMed] 
  11. Ghonemy S. Treatment of recalcitrant plantar warts with long-pulsed Nd:YAG laser versus cantharidin-podophylline resin-salicylic acid. J Cosmet Laser Ther. 2017;19(6):347-52. [Crossref]  [PubMed] 
  12. Gheisari M, Iranmanesh B, Nobari NN, Amani M. Comparison of long-pulsed Nd: YAG laser with cryotherapy in treatment of acral warts. Lasers Med Sci. 2019;34(2):397-403. [Crossref]  [PubMed] 

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