Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
The Clinical and Histological Analysis of 140 Cases of Ameloblastoma: An Emphasis to Histological Variants
140 Ameloblastom Olgusunun Klinik ve Histolojik Analizi: Histolojik Varyantların Değerlendirilmesi
Ömür DERECİa, Devrim KAHRAMANb, Yasin Çağlar KOŞARa, Ülker Yalçın KARAGECEc, Ömer GÜNHANb
aEskişehir Osmangazi University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Eskişehir, TURKEY
bTOBB Economy and Technology University, Faculty of Medicine, Department of Pathology, Ankara, TURKEY
cGören Pathology Laboratory, Ankara, TURKEY
Turkiye Klinikleri J Dental Sci. 2020;26(3):393-401
doi: 10.5336/dentalsci.2019-71833
Article Language: EN
Full Text
ABSTRACT
 Objektive: The objective of this study is to evaluate the clinical and demographic features of ameloblastoma cases of a pathology center with a detailed examination of the histopathological properties of the subtypes and variants. Material and Methods: The clinical and radiological data and histologic slides of ameloblastoma cases diagnosed and treated between 2005 and 2017 were retrieved from the archives. Histopathological features of previously diagnosed cases were re-evaluated and re-classification of all cases was performed in accordance with the World Health Organization (WHO) classification of odontogenic tumors. The significance of the relationship between radiological appearance (multiocularity/unilocularity) and final histological diagnosis (solid/unicystic) was evaluated with statistical analysis. Results: There were a total of a hundred and forty cases of ameloblastoma. A hundred and twenty (85.7%) cases were diagnosed as solid type. Sixteen (11.4%) cases were diagnosed as unilocular ameloblastoma. Three cases showed admixed histopathological characteristics. There was a significant relationship between radiological appearance and histological diagnosis (p=0.005). All recurrent luminal unicystic ameloblastomas were re-diagnosed as mural subtype in the histopathological examination. Conclusion: The presence of rare variants should be diagnosed correctly with a thorough histopathological examination to contribute to the prognosis. The radiographic appearance of the tumor is correlated with the histological subtype. In the examination of recurrent unicystic cases, the surgical specimen should be entirely inspected to indicate mural ameloblastic invasions.

Keywords: Ameloblastoma; histopathology; diagnosis
ÖZET
 Amaç: Bu çalışmanın amacı, bir patoloji merkezindeki ameloblastoma olgularının alt tiplerinin ve varyantlarının histopatolojik özelliklerini detaylı şekilde inceleyip klinik ve demografik özelliklerini değerlendirmektir. Gereç ve Yöntemler: 2005-2017 yılları arasında tanı koyulan ve tedavi edilen ameloblastoma olgularının klinik ve radyolojik verileri ve histolojik kesitleri arşivlerden temin edildi. Önceden tanı alan olguların histopatolojik özellikleri yeniden değerlendirildi ve tüm olguların Dünya Sağlık Örgütü (DSÖ) odontojenik tümör sınıflamasına göre yeniden sınıflandırılması yapıldı. Radyolojik görünüm (multiloküler / uniloküler) ile nihai histolojik tanı (solid / unikistik) arasındaki ilişkinin istatistiksel analiz ile değerlendirilmesi yapıldı. Bulgular: Çalışmaya toplam 140 ameloblastoma olgusu dahil edildi. Yüz yirmi (%85,7) olgu solid tip olarak teşhis edildi. On altı (%11,4) olguya uniloküler ameloblastom tanısı kondu. Üç vakada rutin sınıflama içerisine girmeyen çeşitli histopatolojik özellikler gösterildi. Radyolojik görünüm ile histolojik tanı arasında anlamlı bir ilişki saptandı (p= 0.005). Tüm rekürrent lüminal unikistik ameloblastomlara histopatolojik incelemede mural alt tipi olarak tekrar tanı koyuldu. Sonuç: Ameloblastoma olgularında nadir varyantların varlığı prognoza katkıda bulunması için ayrıntılı bir histopatolojik inceleme ile doğru şekilde teşhis edilmelidir. Tümörün radyografik görünümü ile histolojik alt tipi arasında ilişki bulunmaktadır. Tekrarlayan unikistik olguların muayenesinde, cerrahi örnek, mural ameloblastik invazyonu göstermek için bir bütün olarak incelenmelidir.

Anahtar Kelimeler: Ameloblastom; histopatholoji; teşhis
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