Journal of Reconstructive Urology

.: ORIGINAL RESEARCH
The Association Between Mean Platelet Volume, Platelet Distribution Width, Platelet Count and Varicocele
Ortalama Trombosit Hacmi, Trombosit Dağılım Genişliği ve Trombosit Sayısının Varikosel ile İlişkisi
Özgür YAZICIa, Alper KAFKASLIa, Utku CANa
aDepartment of Urology, Dr. Lütfi Kırdar Kartal Training and Research Hospital, İstanbul, TURKEY
J Reconstr Urol. 2020;10(3):88-92
doi: 10.5336/urology.2020-76294
Article Language: EN
Full Text
ABSTRACT
 Objective: The relationship between the increase in the mean platelet volume, which is the determinant of platelet activation, and vascular pathologies is known. Therefore, in order to elucidate varicocele etiopathogenesis, we aimed to examine whether there is an any connection among MPV and varicocele. Material and Methods: 348 patients who underwent unilateral varicocelectomy in our clinic between 2013 and 2019 were prospectively comprised in the study. Patient's age, MPV in complete blood count, platelet distribution width (PDW), platelet count (PC) and mean varicose vein diameters were recorded. These parameters were compared between patient groups (Group 1 is level 1 varicocele patients; Group 2 is level 2 varicocele patients and Group 3 is level 3 varicocele patients), which were divided according to the varicocele grades determined by scrotal Doppler USG and it was checked whether there was a difference between the groups. Results: Mean age of the patients was 27.6±7.1 years. While 44 of 348 patients had varicocele was right-sided, the remaining 304 patients had left-sided varicocele. Varicocele was Grade 3 in 71 (20.5%) patients, Grade 2 in 239 (68.7%) and Grade 1 in the remaining 38 (10.9%). The mean VVD (mm) value for all groups was 4.2±1.2. There was no significant difference between the groups in terms of age and TS (p=0.056 and p=0.071, respectively). There was a statistically significant difference between three groups in terms of PDW and MPV values (p=0.025 and p=0.018, respectively). Group 3 was significantly higher for both parameters than Group 1. According to the spearman correlation coefficient calculated by using VVD and PC, PDW, and MPV parameters, it was found that the VVD showed a significant positive correlation with PDW and MPV (r=0.190, p=0.002 and r=0.201, p=0.001 respectively). Conclusion: Based on the importance of the vascular component in the pathophysiology of varicocele, it should be emphasized that it supports the hypothesis that varicocele may be a component of systemic venous anomalies.

Keywords: Mean platelet volume; varicocele
ÖZET
 Amaç: Trombosit aktivasyonunun belirleyicisi olan ortalama trombosit hacmindeki (OTH) artışın vasküler patolojilerle olan ilişkisi bilinmektedir. Bu nedenle de varikoselin etiyopatogenezini aydınlatmak için OTH ve varikosel arasında bir ilişki olup olmadığını incelemeyi amaçladık. Gereç ve Yöntemler: 2013-2019 Ocak ayları arasında kliniğimizde tek taraflı varikoselektomi operasyonu yapılan 348 hasta prospektif olarak çalışmaya dâhil edildi. Hastaların yaşı, tam kan sayımındaki OTH, trombosit dağılım genişliği (TDG), trombosit sayısı (TS) ve ortalama varikoz ven çapları (VVÇ) kayıt edildi. Bu parametreler, skrotal Doppler ultrasonografi (USG) ile belirlenen varikosel derecelerine göre ayrılan hasta grupları (Grup 1, derece 1 varikosel; Grup 2, derece 2 varikoseli ve Grup 3, derece 3 varikosel) arasında karşılaştırıldı ve gruplar arasında bir fark olup olmadığına bakıldı. Bulgular: Ortalama hasta yaşı 27,6±7,1 yıl idi. 348 hastanın 44'ünde varikosel sağ taraflı iken kalan 304 hastada varikosel sol taraflı idi. Hastaların 71'inde (%20,5) varikosel derece 3 iken, 239'unda (%68,7) derece 2 ve kalan 38'inde (%10,9) derece 1 idi. Tüm gruplar için VVÇ (mm) ortalama değeri 4,2±1,2 idi. Gruplar arasında yaş ve TS açısından anlamlı bir fark yoktu (sırasıyla; p=0,056 ve p=0,071). Gruplar arasında TDG ve OTH değerleri açısından yapılan incelemede istatistiksel anlamlı farklılık saptandı (sırasıyla, p=0,025 ve p=0,018). Her iki parametre için de Grup 3, Grup 1'e göre anlamlı olarak yüksek izlendi. VVÇ ile TS, TDG ve OTH arasında yapılan spearman korelasyon katsayısına göre VVÇ'nin TDG ve OTH ile anlamlı düzeyde pozitif korelasyon gösterdiği saptandı (sırasıyla r=0,190, p=0,002 ve r=0,201, p=0,001). Sonuç: Varikoselin patofizyolojisinde vasküler bileşenin önemine dayanarak vurgulanmalıdır ki çıkan sonuç; varikoselin sistemik venöz anomalilerin bir bileşeni olabileceği hipotezini desteklemektedir.

Anahtar Kelimeler: Ortalama trombosit hacmi; varikosel
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