Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
The 8q24 Rs10090154c>T Gene Variant and Its Association with the Risk of Prostate Cancer: A Systematic Review and Meta-analysis
8q24 Rs10090154>T Gen Varyantı ve Prostat Kanseri Riski ile İlişkisi: Sistematik Gözden Geçirme ve Meta-analiz
Buyung PRASETYAWANa, Sirin SALSABILAa, Muhammad ILMAWANa, Besut DARYANTOb, Jonny Karunia FAJARc
aMedical Research Unit, Universitas Brawijaya Faculty of Medicine, Malang, INDONESIA
bNephro Genito Urinary Brawijaya Research Center, Universitas Brawijaya Faculty of Medicine,Malang, INDONESIA
c Brawijaya Internal Medicine Research Center, Universitas Brawijaya Faculty of Medicine, Malang, INDONESIA
Turkiye Klinikleri J Med Sci. 2021;41(2):166-75
doi: 10.5336/medsci.2020-79798
Article Language: EN
Full Text
ABSTRACT
 Objective: Genetic variation at chromosome 8q24 is considered as the potential biomarker for prostate cancer. We aimed to assess the relation between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer. Material and Methods: A meta-analysis was carried out in January to June 2020 by collecting relevant studies through online databases. The correlation and estimated effect between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer were analyzed using a Z test. Results: A total of 16 relevant studies were selected (16,842 cases and 18,258 controls). In overall, T allele and CT genotype of 8q24 rs10090154C>T gene polymorphism increased the risk of prostate cancer (OR95%CI=1.238 [1.14-1.34], pT was associated with increased risk of prostate cancer (OR95%CI=1.285 [1.07-1.54], pT was correlated with increased risk of prostate cancer (OR95%CI=1.302 [1.17-1.45], pT gene polymorphism had strong association with the risk of prostate cancer.

Keywords: Prostate cancer; MYC; gene polymorphism; meta-analysis
ÖZET
 Amaç: Kromozom 8q24'deki genetik varyasyon prostat kanseri için potansiyel bir biyobelirteç olarak düşünülür. 8q24 rs10090154C>T gen varyantı ile prostat kanseri riski arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç ve Yöntemler: Çevrimiçi veri tabanlarını kullanarak Ocak-Haziran 2020 tarihleri arasındaki ilgili çalışmaları toplamak suretiyle bir meta-analiz yaptık. 8q24 rs10090154C>T gen varyantı ile prostat kanseri riski arasındaki korelasyon ve tahmini etki Z testi kullanılarak analiz edildi. Bulgular: Toplam 16 çalışma seçildi (16,842 olgu ve 18,258 kontrol). Toplamda, T aleli ve of 8q24 rs10090154C>T gen polimorfizminin CT genotipi prostat kanserini artırıyorken (OR, %95 GA=1.238 [1.14-1.34], pT'nin T alelinin artmış prostat kanseri riski ile ilişkili olduğunu (OR %95 GA=1.285 [1.07- 1.54], pT'nin CT genotipi, prostat kanseri riskinin artmasıyla korele iken (OR %95 GA=1,302 [1,17-1.45], pT gen polimorfizminin prostat kanseri riski ile güçlü bir ilişkisi olduğunu doğruladı.

Anahtar Kelimeler: Prostat kanseri; MYC; gen polimorfizmi; meta-analiz
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