Turkiye Klinikleri Journal of Dermatology

.: CASE REPORTS
Setuksimab ile İndüklenen Akneiform Erüpsiyon, Paronişi, Kserozis, Blefarit, Konjonktivit: İki Olgu Sunumu
Cetuximab-Induced Acneiform Eruption, Paronychia, Xerosis, Blepharitis, Conjunctivitis: Two Case Reports
İrem Nur DURUSUa, Dilara GÜLERa, Gülhan GÜRELa
aAfyonkarahisar Sağlık Bilimleri Üniversitesi Tıp Fakültesi, Deri ve Zührevi Hastalıkları ABD, Afyonkarahisar, TÜRKİYE
Turkiye Klinikleri J Dermatol. 2021;31(3):233-7
doi: 10.5336/dermato.2020-80069
Article Language: TR
Full Text
ÖZET
 Epidermal büyüme faktörü reseptör inhibitörleri (EBFR-İ), birçok solid organ malignitelerinde tedavide kullanımı nispeten yeni sayılabilecek bir grup ilaçlardır. Standart kemoterapi rejimleri replikasyon gösteren çoğu hücreyi hedef alırken, EBFR-İ çoğunlukla kanser hücrelerinin bölünmesinde ve çoğalmasında görev alan yolakları hedef alır. Bununla birlikte keratinosit, sebosit, saç folikülü hücreleri gibi malign olmayan hücrelerin normal hücresel büyüme ve farklılaşma sürecinde de EBFR görev almaktadır. EBFR-İ kullanımı ile kutanöz yan etkilerin görülme sıklığı %80'in üzerindedir. Bu yan etkilerden; akneiform döküntü, eritem, kserozis, fissürler, pruritus, tırnak değişiklikleri (onikolizis, piyojenik granülom, paronişi) sıklıkla sözü geçen durumlardır. Ayrıca saç değişiklikleri, mukozit, fotosensitivite, telenjiyektazi, hiperpigmentasyon, mukokutanöz hemoraji, gecikmiş yara iyileşmesi, konjunktivit ve blefarit ile prezente olabilen göz tutulumu bildirilmiştir. Kutanöz yan etkilerin olup olmamasının, surviyi belirlemede bir prediktif değeri olabileceği belirlenmiştir. Bu yazıda, setuksimaba bağlı farklı şiddette 1'den fazla kutanöz yan etki gelişen 2 farklı kadın olgu sunulmaktadır.

Anahtar Kelimeler: Akneiform erüpsiyonlar; blefarit; konjonktivit; paronişi; setuksimab
ABSTRACT
 Epidermal growth factor receptor inhibitors (EGFR-I) are a group of drugs that can be considered new to compare their use in the treatment of many solid organ malignancies. While standard chemotherapy regimens target most of the replicating cells, EGFR-I mostly target the pathways involved in the proliferation of cancer cells. However, EGFR is also involved in the normal cellular growth and differentiation process of non-malignant cells such as keratinocytes, sebocytes, and hair follicle cells. The frequency of cutaneous side effects with the use of EGFR-I is over 80%. Among these side effects, acneiform rash, erythema, xerosis, fissures, pruritus, nail changes (onycholysis, pyogenic granuloma, paronychia) are frequently mentioned. In addition; hair changes, mucositis, photosensitivity, telangiectasia, hyperpigmentation, mucocutaneous hemorrhage, delayed wound healing, eye involvement that may present with conjunctivitis and blepharitis have been reported. It has been indicated that the presence or absence of cutaneous side effects may have a predictive value in determining the survival of patients. In this article, two different female cases who developed more than one cutaneous side effect of different severity due to cetuximab are presented

Keywords: Acneiform eruptions; blepharitis; conjunctivitis; paronychia; cetuximab
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Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

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Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

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-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

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-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

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Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

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