Turkiye Klinikleri Archives of Lung

.: ORIGINAL RESEARCH
Relationship Between Asymptomatic COVID-19 and Pulmonary Embolism: Case-Control Study
Asemptomatik COVID-19 ve Pulmoner Emboli İlişkisi: Olgu-Kontrol Çalışması
Olcay AYÇİÇEKa , Esra ÖZKAYAb, Mehtap PEHLİVANLAR KÜÇÜKc , Merve ÖZDOĞAN ALGINa , Celal Kurtuluş BURUK b , Funda ÖZTUNAa
aDepartment of Chest Diseases, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye
bDepartment of Medical Microbiology, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye
cDepartment of Chest Diseases, Division of Intensive Care Unit, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye
Turkiye Klinikleri Arch Lung. 2023;22(1):1-5
doi: 10.5336/archlung.2022-92914
Article Language: EN
Full Text
ABSTRACT
 Objective: The incidence of pulmonary embolism (PE) has increased in coronavirus disease-2019 (COVID-19) infection. The aim of study is to determine whether there is an increase in the frequency of PE in asymptomatic COVID-19 patients. Material and Methods: Patients who were diagnosed with PE our hospital, who did not have COVID-19 and who were not vaccinated against COVID-19 were included in the study group and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody levels were examined. The control group was consisted of patients who did not have PE, had not had COVID-19 and were not vaccinated and SARSCoV-2 antibody levels were examined. The antibody positivity rates, antibody titer levels of both groups were compared. Results: A total of 32 patients, 16 in the study group and 16 in the control group, were included in the study. Of all patients, 22 (68.8%) were male, 10 (31.3%) were female. While the mean age of men was 47.36±14.86, women was 51±24.463 (p=0.671). There was no statistically difference between the 2 groups in terms of mean age (p=0.346). When the groups were compared in terms of SARS-CoV-2 antibody, antibody positivity was found in 7 (43.8%) patients in both the study group and the control group (p=1.000). There wasn't difference between the groups antibody titers (p=0.275). The rate of asymptomatic COVID19 infection in patients with PE was found to be similar to the population followed with non-PE diagnoses. Conclusion: The results of study show that there is no increase in the risk of PE in patients with asymptomatic COVID-19 infection.

Keywords: COVID-19; pulmonery embolism
ÖZET
 Amaç: Koronavirüs hastalığı-2019 (COVID-19) enfeksiyonunda pulmoner emboli (PE) insidansı artmıştır. Çalışmanın amacı asemptomatik COVID-19 hastalarında PE sıklığında artış olup olmadığını belirlemektir. Gereç ve Yöntemler: Hastanemizde PE tanısı alan, COVID-19 olmayan ve COVID-19 aşısı olmayan hastalar çalışma grubuna alındı ve şiddetli akut solunum sendromu-koronavirüs-2 (SARS-CoV)-2) antikor seviyelerine bakıldı. Kontrol grubu PE olmayan, COVID-19 geçirmemiş ve aşılanmamış hastalardan oluşturuldu ve SARS-CoV-2 antikor düzeyleri bakıldı. Her iki grubun antikor pozitiflik oranları, antikor titre düzeyleri karşılaştırıldı. Bulgular: Çalışma grubuna 16, kontrol grubuna 16 olmak üzere toplam 32 hasta dahil edildi. Tüm hastaların 22'si (%68,8) erkek, 10'u (%31,3) kadındı. Erkeklerin yaş ortalaması 47,36±14,86 iken kadınların 51±24,463'tür (p=0,671). Yaş ortalamaları açısından 2 grup arasında istatistiksel olarak fark yoktu (p=0,346). Gruplar SARS-CoV-2 antikoru açısından karşılaştırıldığında hem çalışma grubunda hem de kontrol grubunda 7 (%43,8) hastada antikor pozitifliği saptandı (p=1.000). Gruplar arasında antikor titreleri arasında fark yoktu (p=0,275). PE'li hastalarda asemptomatik COVID-19 enfeksiyonu oranı, PE olmayan tanılarla takip edilen popülasyona benzer bulundu. Sonuç: Çalışmanın sonuçları asemptomatik COVID-19 enfeksiyonu olan hastalarda PE riskinde artış olmadığını göstermektedir.

Anahtar Kelimeler: COVID-19; pulmoner emboli
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