Turkiye Klinikleri Journal of Veterinary Sciences

.: ORIGINAL RESEARCH
Rectal Enema Multi Strain Probiotic Therapy Might Mitigate Pruritus, Dermatology Triage and Diamine Oxidase Levels Among Dogs with Food Allergy: Cohort Study
Rektal Enema Çoklu Suş Probiyotik Tedavisi Gıda Alerjisi Olan Köpeklerde Kaşıntı, Dermatoloji Triajı ve Diamin Oksidaz Düzeylerini Azaltabilir: Kohort Çalışması
Kerem URALa
aAydın Adnan Menderes University Faculty of Veterinary, Department of Internal Medicine, Aydın, Türkiye
Turkiye Klinikleri J Vet Sci. 2024;15(1):9-14
doi: 10.5336/vetsci.2023-96091
Article Language: EN
Full Text
ABSTRACT
 Objective: The incidence and spatial distribution of allergic diseases are significantly increasing in university practice along with field conditions. Increased plasma levels of histamine and diminished diamine oxidase (DAO) activity have been explored as biomarkers of deduced histamine catabolism. Given histamine participates in allergic inflammation, recent data presented the beneficial efficacy of probiotics for combatting. In the present study the aim was to determine the efficacy of rectal enema multi-strain probiotic chain treatment against food allergy (FA) and relevant clinical signs. Material and Methods: In a total of 8 dogs' diagnosis of FA was based on i) history, ii) clinical signs and iii) adopting a trial diet with low carbohydrate. Demographic data involved breed, triage level of pruritus (black color coded severe pruritus, whereas red and green denoted: moderate and minor itching behaviour). DAO levels were determined by use of dog specific test kits via ELISA. Results: At the end of a 10 days trial of rectal enema multi-strain probiotic treatment both pruritus scores and tirage levels were diminished. Mean blood DAO levels (ng/mL) of circulating values were comperatively addicted to before and after treatment (5 vs. 12). Besides DAO levels were significantly increased at day 10 analytes, in contrast to day 0 initial values. Rectal enema multi-strain probiotic treatment was well tolerated without any adverse effects. Conclusion: It was strictly suggested that rectal enema multi-strain probiotic therapy could i) lower pruritus scores and alter triage colors, ii) increase DAO levels in dogs with FA.

Keywords: Diamine oxidase; food allergy; dog
ÖZET
 Amaç: Alerjik hastalıkların insidansı ve anlık dağılımı, üniversite pratiğinde saha koşullarıyla birlikte önemli ölçüde artmaktadır. Artan plazma histamin seviyeleri ve azalan diamin oksidaz (DAO) aktivitesi, histamin katabolizmasının bir biyobelirteci olarak keşfedilmiştir. Histamin, alerjik inflamasyona katıldığı göz önüne alındığında son veriler, probiyotiklerin mücadele için yararlı etkinliğini ortaya koymuştur. Bu çalışmanın amacı, rektal lavman yoluyla çoklu suş probiyotik zincir tedavisinin gıda alerjisine [food allergy (FA)] ve ilgili klinik belirtilere karşı etkinliğini belirlemektir. Gereç ve Yöntemler: Toplam 8 köpekte FA tanısı i) öykü, ii) klinik belirtiler, iii) düşük karbonhidratlı bir deneme diyetinin benimsenmesine dayandırıldı. Demografik veriler kaşıntının ırkını, triaj seviyesini (siyah renk kodlu şiddetli kaşıntıyı, kırmızı ve yeşil ise orta ve hafif kaşıntı davranışı) içeriyordu. DAO seviyeleri, ELISA yoluyla köpeğe özgü test kitleri kullanılarak belirlendi. Bulgular: On günlük rektal enema çoklu suş probiyotik tedavisi denemesinin sonunda, hem kaşıntı skorları hem de tiraj seviyeleri azaldı. Ortalama kan DAO seviyeleri (ng/mL), öncesi ve sonrası gibi karşılaştırmalı olarak (5'e karşı 12) bağımlıydı. Ayrıca DAO seviyeleri, 0. gün başlangıç değerlerinin aksine 10. gün analitlerinde önemli ölçüde arttı. Rektal enema probiyotik tedavisi, herhangi bir yan etki olmaksızın iyi tolere edildi. Sonuç: Rektal enema çoklu probiyotik suş tedavisinin i) kaşıntı skorlarını azaltabileceği ve triaj renklerini değiştirebileceği, ii) FA'lı köpeklerde DAO seviyelerini artırabileceği kesinlikle önerildi.

Anahtar Kelimeler: Diamin oksidaz; gıda alerjisi; köpek
REFERENCES:
  1. Jutel M, Watanabe T, Klunker S, Akdis M, Thomet OA, Malolepszy J, et al. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature. 2001;413(6854):420-5. [Crossref]  [PubMed] 
  2. Breunig E, Michel K, Zeller F, Seidl S, Weyhern CW, Schemann M. Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors. J Physiol. 2007;583(Pt 2):731-42. [Crossref]  [PubMed]  [PMC] 
  3. Lockwood JM, Wilkins BW, Halliwill JR. H1 receptor-mediated vasodilatation contributes to postexercise hypotension. J Physiol. 2005;563(Pt 2):633-42. [Crossref]  [PubMed]  [PMC] 
  4. Egawa G, Nakamizo S, Natsuaki Y, Doi H, Miyachi Y, Kabashima K. Intravital analysis of vascular permeability in mice using two-photon microscopy. Sci Rep. 2013;3:1932. [Crossref]  [PubMed]  [PMC] 
  5. Ashina K, Tsubosaka Y, Nakamura T, Omori K, Kobayashi K, Hori M, et al. Histamine induces vascular hyperpermeability by increasing blood flow and endothelial barrier disruption in vivo. PLoS One. 2015;10(7):e0132367. [Crossref]  [PubMed]  [PMC] 
  6. Carlotti DN, Dip ECVD. Food allergy in dogs and cats: current dermatological perspectives. 2017. [Link] 
  7. Jackson HA. Dermatologic manifestations and nutritional management of adverse food reactions. Veterinary medicine. 2007. [Link] 
  8. Mueller RS, Friend S, Shipstone MA, Burton G. Diagnosis of canine claw disease - a prospective study of 24 dogs. Vet Dermatol. 2000;11(2):133-41. [Crossref]  [PubMed] 
  9. Ural K, Erdoğan S, Balıkçı C, Erdoğan H, İçaçan G. İnovatif gastroentero-dermatoloji kapsamında muhtelif yöntem geliştirme I: Lactobacillus plantarum ve Lactobacillus paracasei ile probiyotik eneması atopik dermatitli köpeklerde anti-pruritik etkinlik sağlar mı? [Development of various methods in innovative gastroentero-dermatology I: does probiotic enema with Lactobacillus plantarum and Lactobacillus paracasei provide anti-pruritic efficacy in dogs with atopic dermatitis?]. Van Vet J. 2021;32(2):74-81. [Crossref] 
  10. Ural K, Erdogan H, Erdogan S. A new era under soil based probiotics for anti-pruritic combat among cats with feline atopic skin syndrome. International Journal of Veterinary and Animal Research (IJVAR). 2022;5(2):89-93. [Crossref] 
  11. Ural K, Erdoğan H, Erdoğan S, Çamkerten I, Şahin N. Circulating serum zonulin levels before and after probiotic enema treatment in dogs with atopic dermatitis: randomized clinical study. Turkiye Klinikleri J Vet Sci. 2021;12(2):70-8. [Crossref] 
  12. Björkstén B. Effects of intestinal microflora and the environment on the development of asthma and allergy. Springer Semin Immunopathol. 2004;25(3-4):257-70. [Crossref]  [PubMed] 
  13. Kim H, Lee SY, Ji GE. Timing of bifidobacterium administration influences the development of allergy to ovalbumin in mice. Biotechnol Lett. 2005;27(18):1361-7. [Crossref]  [PubMed] 
  14. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol. 2007;119(1):192-8. [Crossref]  [PubMed] 
  15. Dev S, Mizuguchi H, Das AK, Matsushita C, Maeyama K, Umehara H, et al. Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect. J Pharmacol Sci. 2008;107(2):159-66. [Crossref]  [PubMed] 
  16. Xiao JZ, Kondo S, Yanagisawa N, Takahashi N, Odamaki T, Iwabuchi N, et al. Effect of probiotic Bifidobacterium longum BB536 [corrected] in relieving clinical symptoms and modulating plasma cytokine levels of Japanese cedar pollinosis during the pollen season. A randomized double-blind, placebo-controlled trial. J Investig Allergol Clin Immunol. 2006;16(2):86-93. Erratum in: J Investig Allergol Clin Immunol. 2006;16(4):273. [PubMed] 
  17. Xiao JZ, Kondo S, Yanagisawa N, Takahashi N, Odamaki T, Iwabuchi N, et al. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clin Exp Allergy. 2006;36(11):1425-35. [Crossref]  [PubMed] 
  18. Xiao JZ, Kondo S, Yanagisawa N, Miyaji K, Enomoto K, Sakoda T, et al. Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergol Int. 2007;56(1):67-75. [Crossref]  [PubMed] 
  19. Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M, Stahlknecht CD. Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects? Agents Actions. 1985;16(3-4):91-4. [Crossref]  [PubMed] 
  20. Kusche J, Stahlknecht CD, Lorenz W, Reichert G, Richter H. Diamine oxidase activity and histamine release in dogs following acute mesenteric artery occlusion. Agents Actions. 1977;7(1):81-4. [Crossref]  [PubMed] 
  21. Deepika Priyadarshani WM, Rakshit SK. Screening selected strains of probiotic lactic acid bacteria for their ability to produce biogenic amines (histamine and tyramine). International Journal of Food Science & Technology. 2011;46(10):2062-9. [Crossref] 
  22. Leuschner RG, Hammes WP. Degradation of histamine and tyramine by Brevibacterium linens during surface ripening of Munster cheese. J Food Prot. 1998;61(7):874-8. [Crossref]  [PubMed] 
  23. Joneja JM. Histamine intolerance, diamine oxidase activity, and probiotics. Vickerstaff Health Services. 2004. Date of access: 01.05.2024. [Link] 
  24. Hershko AY, Dranitzki Z, Ulmanski R, Levi-Schaffer F, Naparstek Y. Constitutive hyperhistaminaemia: a possible mechanism for recurrent anaphylaxis. Scand J Clin Lab Invest. 2001;61(6):449-52. [Crossref]  [PubMed] 

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