Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Psödoeksfoliasyon Sendromu/Glokomu ile Serum D Vitamini, B12 Vitamini, Folat, Demir Parametreleri ve İnflamasyon Belirteçlerinin İlişkisi: Retrospektif Kesitsel Çalışma
Relationship between Pseudoexfoliation Syndrome/Glaucoma and Serum Vitamin D, Vitamin B12, Folate, Iron Parameters and Inflammation Markers: Retrospective Cross-Sectional Study
Işıl Merve TORUNa , Hasine Gözde DALKILIÇa , Nureddin KARAKAŞa
aSağlık Bilimleri Üniversitesi Sultan 2. Abdülhamid Han Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, İstanbul, Türkiye
Turkiye Klinikleri J Ophthalmol. 2023;32(4):245-52
doi: 10.5336/ophthal.2023-98549
Article Language: TR
Full Text
ÖZET
 Amaç: Psödoeksfoliasyon sendromu (PES) veya glokomu (PEG) olan hastalarda D vitamini, B12 vitamini, folat, demir, total demir bağlama kapasitesi [total iron binding capacity (TIBC)], ansatüre demir bağlama kapasitesi [unsaturated iron binding capacity (UIBC)], nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO), Creaktif protein (CRP), eritrosit sedimantasyon hızı (ESH) seviyelerini değerlendirmek ve benzer yaş-cinsiyette psödoeksfoliasyonu olmayan sağlıklı kontrol grubuyla kıyaslamak. Gereç ve Yöntemler: Bu retrospektif çalışmaya Sultan Abdülhamid Han Eğitim ve Araştırma Hastanesine Ocak 2022-Ocak 2023 tarihleri arasında başvurmuş 64 PES/PEG tanılı hasta ile benzer yaş ve cinsiyette 32 kontrol hastası dâhil edildi. Hastanemizin biyokimya bölümü tarafından analiz edilmiş venöz kan örneklerinin sonuçları değerlendirmeye alındı. Çalışmada elde edilen bulgular değerlendirilirken, istatistiksel analizler için IBM SPSS Statistics 26.0 (IBM SPSS, Türkiye) programı kullanıldı. Bulgular: PES/PEG grubunun D vitamini ve B12 vitamini seviyeleri kontrol grubuna göre istatistiksel olarak anlamlı düşük bulundu (sırasıyla p=0,007, p=0,045). Her iki grup arasında serum demir, folat, TIBC, UIBC, NLO, PLO, CRP, ESH açısından istatistiksel olarak anlamlı fark görülmedi (her biri için p>0,05). PES'li olguları PEG'li olgularla kıyasladığımızda D vitamini, B12, folat, demir, TIBC, UIBC, NLO, PLO, CRP, ESH değerleri açısından iki grup arasında istatistiksel olarak anlamlı bir fark bulunmadı (her biri için p>0,05). Sonuç: Serum D vitamini ve B12 vitamini düzeyinin düşüklüğü ile PES/PEG arasında bir ilişki bulunmuştur. Bu bulgular bize hastalığın etiyopatogenezi ve tedavisi hakkında ipuçları verebilir.

Anahtar Kelimeler: B12 vitamini; D vitamini; glokom; psödoeksfoliasyon
ABSTRACT
 Objective: To evaluate vitamin D, vitamin B12, folate, iron, total iron binding capacity (TIBC), unsaturated iron binding capacity (UIBC), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) levels in patients with pseudoexfoliation syndrome (PES) or glaucoma (PEG) and to compare with a healthy control group of similar age and gender without pseudoexfoliation. Material and Methods: This retrospective study included 64 PES/PEG patients who applied to the Sultan Abdülhamid Han Training and Research Hospital between January 2022 and January 2023, as well as 32 control patients of comparable age and gender. The outcomes of our hospital's biochemistry department's analysis of venous blood samples were evaluated. For statistical analysis, IBM SPSS Statistics 26.0 (IBM SPSS, Türkiye) was used to evaluate the study's findings. Results: Vitamin D and vitamin B12 levels of the PES/PEG group were found to be statistically significantly lower than the control group (p=0.007, p=0.045, respectively). There was no statistically significant difference between the two groups in terms of serum iron, folate, TIBC, UIBC, NLR, PLR, CRP, and ESR (p>0.05 for each). When we compared the cases with PES with the cases with PEG, no statistically significant difference was found between the two groups in terms of vitamin D, B12, folate, iron, TIBC, UIBC, NLR, PLO, CRP, ESH values (p>0.05 for each). Conclusion: A correlation was found between low serum vitamin D and vitamin B12 levels and PES/PEG. These findings may give us clues about the etiopathogenesis and treatment of the disease.

Keywords: Vitamin B12; vitamin D; glaucoma; pseudoexfoliation
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