Turkiye Klinikleri Cardiovascular Sciences

.: ORIGINAL RESEARCH
Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon
Koroner Yavaş Akım Fenomeninde Oransal Serum Lipid Parametreleri
Belma KALAYCIa, Süleyman KALAYCIb, Fürüzan KÖKTÜRKc
Departments of
aCardiology,
cBiostatistics, Zonguldak Bülent Ecevit University Faculty of Medicine,
bClinic of Cardiology, Zonguldak Atatürk State Hospital, Zonguldak, TURKEY
Turkiye Klinikleri J Cardiovasc Sci. 2019;31(1):21-8
doi: 10.5336/cardiosci.2018-63794
Article Language: EN
Full Text
ABSTRACT
 Objective: The association between serum lipid parameters and coronary slow-flow (CSF) phenomenon has been searched previously. The aim of our study was to determine the association between proportional serum lipid parameters and CSF. Material and Methods:We enrolled 93 stable patients randomly who had undergone coronary angiography and had near-normal coronary arteries with normal and slow coronary flow. Demographic, clinical and laboratory data were recorded retrospectively. Coronary flow velocity was evaluated by TIMI frame count (TFC). CFS phenomenon was defined as a TFC greater than 27 frames. Corrected TFC was calculated for the left anterior descending coronary artery. Results: Fifty four patients were in CSF group and 39 patients were in control group. The mean age of the patients in CSF group was significantly higher than control group (55.4±9.5 vs. 50.5±9.8 years, p= 0.019). Triglyceride (TG) levels was found higher in CSF group than control group (187.3±103.4 mg/dl, 125.3±63.8 mg/dl, p<0.001). Total cholesterol to high density lipoprotein cholesterol ratio (TC/HDL-c), TG/HDL-c, low density lipoprotein cholesterol to HDL-c ratio (LDL-c/HDL-c) and non-HDL-c levels were significantly higher in CSF group (p=0.007, p=0.004, p=0.044, p=0.018, respectively). TG and TG/HDL-c were found correlated with TFC (r=0.280, r=0.262, respectively). In multivariate logistic regression analysis age, smoking and TG were found statistically significant to predict of CSF. TG was found most associated with the presence of CSF (OR: 7.516, p=0.001). Conclusion: Higher TG, TC/HDL-c, TG/HDL-c, LDLc/HDL-c and non-HDL-c levels were related with CSF phenomenon.

Keywords: Dyslipidemia; HDL-triglyceride; triglycerides; coronary slow flow; lipid ratio
ÖZET
 Amaç: Serum lipid parametreleri ve koroner yavaş akım (KYA) fenomeni arasındaki ilişki daha önce araştırılmıştır. Bizim çalışmamızın amacı oransal lipid parametreleri ile KYA arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntemler: Biz çalışmaya koroner anjiyografi yapılan ve normale yakın koroner arterleri olan, normal ve yavaş koroner akıma sahip 93 stabil hastayı randomize dahil ettik. Demografik, klinik ve laboratuvar verileri retrospektif olarak yerel veri tabanından bulunarak kaydedildi. Koroner akım velositesi miyokard infarktüsünde tromboliz kare sayısı (TFC) ile değerlendirildi. KYA fenomeni TFC'nin 27 kare üzerinde olması olarak tanımlandı. Sol ön inen koroner arter için düzeltilmiş TFC hesaplandı. Bulgular: KYA grubunda 54 hasta, kontrol grubunda 39 hasta vardı. KYA gubunda ortalama yaş, kontrol grubuna göre anlamlı olarak daha fazla saptandı (55,4±9,5 yıl, 50,5±9,8 yıl, p=0,019). Trigliserit (TG) seviyesi KYA grubunda kontrol grubuna göre yüksek bulundu (187,3±103,4 mg/dl, 125,3±63,8 mg/dl, p<0,001). Total kolestrolün yüksek yoğunluklu lipoprotein kolestrolüne oranı (TC/HDL-c), TG/HDL-c, düşük yoğunluklu lipoprotein kolestrolün HDL-c'e oranı (LDL-c/HDL-c) ve non-HDL-c seviyesi KYA grubunda anlamlı olarak yüksek saptandı (sırayla, p=0,007, p=0,004, p=0,044, p=0,018). TG ve TG/HDL-c TFC ile korele bulundu. Çok değişkenli lojistik regresyon analizinde yaş, sigara ve TG değeri KYA'ı öngörmede istatistiksel olarak anlamlı bulundu (r=0,280, r=0,262, sırasıyla). TG değeri KYA ile en fazla ilişkili parametre olarak bulundu (OR: 7,516, p=0,001). Sonuç: Yüksek TC/HDL-c, TG/HDL-c, LDL-c/HDLc, TG ve non-HDL-c seviyeleri KYA fenomeni ile ilişkilidir.

Anahtar Kelimeler: Dislipidemi; HDL-trigliserit; trigliseritler; koroner yavaş akım; lipit oranı
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