Turkiye Klinikleri Journal of Health Sciences

.: REVIEW
Probiotics
Probiyotikler
Neşe ORMANCIa
aDepartment of Nutrition and Dietetics, Girne American University Faculty of Health Sciences, Girne, KKTC
Turkiye Klinikleri J Health Sci. 2019;4(1):62-71
doi: 10.5336/healthsci.2018-60337
Article Language: EN
Full Text
ABSTRACT
 Probiotics contain microorganisms, the vast majority of which are microscopic organisms like the useful microbes that happen normally in the human gut. Probiotics have been generally examined in an assortment of gastrointestinal sicknesses. The most-contemplated species incorporate Lactobacillus, Bifidobacterium and Saccharomyces. Be that as it may, an absence of clear rules on when to utilize probiotics and the best probiotic for various gastrointestinal conditions might mistake for family doctors and their patients. Probiotics have an essential part in the upkeep of immunologic balance in the gastrointestinal tract through the immediate association with invulnerable cells. Probiotic adequacy can be species-, dosage, and sickness particular, and the term of treatment relies upon the clinical sign. There is astounding proof that probiotics are compelling for intense irresistible the runs, anti-microbial related the runs, Clostridium difficile-related looseness of the bowels, hepatic encephalopathy, ulcerative colitis, crabby gut disorder, util-itarian gastrointestinal issue, and necrotizing enterocolitis. On the other hand, there is proof that probiotics are not successful for intense pancreatitis and Crohn infection. Probiotics are alright for babies, youngsters, grown-ups, and more seasoned patients, however alert is prompted in the immunologically powerless populace.

Keywords: Probiotics; prebiotics; microorganism; supplement; nutrition; health
ÖZET
 Probiyotikler mikroorganizmalar içerir; büyük çoğunluğu normalde insan bağırsağında oluşan faydalı mikroplar gibi mikroskobik organizmalardır. Probiyotikler genellikle gastorointestinal hastalıklar için incelenmiştir. En çok bakılan türler Lactobacillus, Bifidobacterium ve Saccharomyces'i içerir. Probiyotiklerin ne zaman kullanılacağına dair net kuralların olmaması ve çeşitli gastrointestinal durumlar göz önüne alındığında probiyotikler, aile hekimleri ve hastaları için zararlar ortaya çıkarabilir. Probiyotikler, gastrointestinal sistemdeki immünolojikden genin korunması için yenilmez hücrelerle hemen birleşerek önemli bir rol oynamaktadır. Probiyotik uygunluğu, türlere, doza ve hastalıklara özel olabilir ve tedavisi süresi klinik belirtilere dayanır. Probiyotiklerin yoğun kullanımında, koşullara karşı anti-mikrobiyal, bağırsakların Clostridium ile ilgili gevşekliği, hepatic ensefalopati, ülseratif kolit, huzursuz bağırsak sendromu, yararlı gastrointestinal sorun ve nekrotizan enterekolisi için zorlayıcı olduğuna dair şaşırtıcı kanıtlar vardır. Öte yandan yoğun pankreatit ve Crohn enfeksiyonu için probiyotiklerin başarılı olmadığının kanıtı vardır. Probiyotikler bebekler, gençler, yetişkinler ve ileri yaştaki hastalar için iyidir, ancak immünolojik açıdan güçsüz popülasyonda dikkat edilmelidir.

Anahtar Kelimeler: Probiyotikler; prebiyotikler; mikroorganizma; suplement; beslenme; sağlık
REFERENCES:
  1. Morrow LE, Gogineni V, Malesker MA. Synbiotics and probiotics in the critically ill after the PROPATRIA trial. Curr Opin Clin Nutr Metab Care. 2012;15(2):147-50. [Crossref][PubMed]
  2. Kamada N, Kim YG, Sham HP, Vallance BA, Puente JL, Martens EC, et al. Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science. 2012; 336(6086):1325-9. [Crossref][PubMed][PMC]
  3. Zoetendal EG, Raes J, van den Bogert B, Arumugam M, Booijink CC, Troost FJ, et al. The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates. ISME J. 2012;6(7):1415-26. [Crossref][PubMed][PMC]
  4. Foroutan R. The history and health benefits of fermented food. Food & Nutrition. Academy of Nutrition and Dietetics. 2012;135(5):510-7.
  5. Whitman WB, Coleman DC, Wiebe WJ. Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A. 1998;95(12):6578-83. [Crossref][PubMed][PMC]
  6. Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME. Probiotics and immunity. J Gastroenterol. 2009;44(1):26-46. [Crossref][PubMed]
  7. Sampson TR, Mazmanian SK. Control of brain development, function, and behavior by the microbiome. Cell Host Microbe. 2015;17(5): 565-76. [Crossref][PubMed][PMC]
  8. Marcason W. Probiotics: where do we stand? J Acad Nutr Diet. 2013;113(10):1424. [Crossref][PubMed]
  9. Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across. Science. 2009;326(5960):1694-7. [Crossref][PubMed][PMC]
  10. Ezendam J, van Loveren H. Probiotics: immunomodulation and evaluation of safety and efficacy. Nutr Rev. 2006;64(1):1-14. [Crossref][PubMed]
  11. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-14. [Crossref][PubMed]
  12. Douglas LC, Sanders ME. Probiotics and prebiotics in dietetics practice. J Am Diet Assoc. 2008;108(3):510-21. [Crossref][PubMed]
  13. Gill HS, Guarner F. Probiotics and human health: a clinical perspective. Postgrad Med J. 2004;80(947):516-26. [Crossref][PubMed][PMC]
  14. Dixon S. Prebiotics and Probiotics: What Are They and Why Should I Eat Them? Comprehensive Cancer Center. University of Michigan Comprehensive Cancer Center; 2002. p.7-9.
  15. Malnick S, Melzer E. Human microbiome: from the bathroom to the bedside. World J Gastrointesti Pathophysiol. 2015;6(3):79-85. [Crossref] [PubMed][PMC]
  16. de Vos WM, de Vos EA. Role of the intestinal microbiome in health and disease: from correlation to causation. Nutr Rev. 2012;70 Suppl 1:S45-56. [Crossref][PubMed]
  17. Turnbaugh PJ, Quince C, Faith JJ, McHardy AC, Yatsunenko T, Niazi F, et al. Organismal, genetic and transcriptional variation in the deeply sequenced gut microbiomes of identical twins. Proc Natl Acad Sci U S A. 2010;107(16):7503-8. [Crossref][PubMed][PMC]
  18. Salari P, Nikfar S, Abdollahi M. A meta-analysis and systematic review on the effect of probiotics in acute diarrhea. Inflamm Allergy Drug Targets, In Probiotics and Prebiotics. The Weight Watchers Research Department. 2009;11(1):3-14.
  19. Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012;148(6): 1258-70. [Crossref][PubMed][PMC]
  20. Ranganathan N, Friedman EA, Tam P, Rao V, Ranganathan P, Dheer R. Probiotic dietary supplementation in patients with stage 3 and 4 chronic kidney disease: a 6-month pilot scale trial in Canada. Curr Med Res Opin. 2009;25(8):1919-30. [Crossref][PubMed]
  21. Musso G, Gambino R, Cassader M. Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. Annu Rev Med. 2011;62:361-80. [Crossref] [PubMed]

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