Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Primer Hiperhidrozda Tiroid Hormon Düzeylerinin Etkisi
The Effect of Thyroid Hormone Levels on Primary Hyperhidrosis
Dursun TÜRKMENa
aDeri ve Zührevi Hastalıkları Kliniği, Malatya Eğitim ve Araştırma Hastanesi, Malatya, TÜRKİYE
Turkiye Klinikleri J Dermatol. 2019;29(2):58-63
doi: 10.5336/dermato.2019-70728
Article Language: TR
Full Text
ÖZET
 Amaç: Hiperhidroz (HH), ekrin ter bezlerinin hiperaktif çalışması sonucu deri yüzeyine vücudun normal fizyolojik ihtiyacından daha fazla miktarda ter salgılanması ile karakterize bir hastalıktır. Hipertiroidisi olan hastaların en önemli deri bulgularından biri HH'dur. Klinik pratikte primer HH tanısı koyduğumuz hastaların birçoğunda tiroid hormon düzeyleri referans değerler arasında, ancak üst limite yakın çıkmaktadır. Bu sebeple bu çalışmada, primer HH'lu hastaların tiroid hormon düzeyleri kontrol grubu ile karşılaştırılarak anlamlı bir farklılık olup olmadığının araştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmada primer HH tanısı konulan 168 hasta ile kontrol grubu olarak yaş ve cinsiyet açısından benzer 121 sağlıklı birey yer aldı. HH hastaları ile kontrol grubu tiroid stimüle edici hormon (TSH), serbest triiyodotironin (ST3), serbest tiroksin (ST4) düzeyleri bakımından karşılaştırıldı. Bulgular: Çalışmaya dâhil edilen HH hastalarının %41,7 (70)'si kadın, %58,3 (98)'ü erkek; kontrol grubunun %44,6 (54)'sı kadın, %55,4 (67)'ü erkek idi. HH hastaları ile kontrol grubu karşılaştırıldığında HH grubunda ST3, ST4 düzeyleri anlamlı derecede daha yüksek iken, TSH düzeyleri bakımından hasta ve kontrol grubu arasında anlamlı bir fark bulunmadı. Hasta ve kontrol grubu cinsiyetlere göre alt gruba ayrılıp değerlendirildi. HH'lu erkek hastalarda kontrol grubu erkeklere göre sadece ST3 anlamlı derecede yüksek iken, HH'lu kadın hastalarda ST3 ve ST4 düzeyleri kontrol grubundaki kadınlara göre anlamlı derecede yüksek bulundu. Sonuç: Bu çalışmada ST3 ve ST4 hormonları HH hastalığı ile ilişkilendirilmiştir. Bu konuda yapılacak yeni çalışmalarla desteklendiği takdirde primer HH hastalarında tiroid hormonlarının referans değerlerinin alt sınırına yakın tutulması bir tedavi seçeneği olarak düşünülebilmektedir.

Anahtar Kelimeler: Hiperhidroz; hipertiroidizm; terleme; triiyodotironin; tiroksin
ABSTRACT
 Objective:Hyperhidrosis (HH) is a disease characterized by the secretion of sweat into the skin surface in a greater amount than the normal physiological need of the body as a result of hyperactive study of eccrine sweat glands. One of the most important skin findings of patients with hyperthyroidism is HH. Thyroid hormone levels in most of the patients diagnosed as primary HH in clinical practice are within the reference values but close to the upper limit. Therefore, in this study, thyroid hormone levels of patients with primary HH were compared with the control group to determine whether there was a significant difference. Material and Methods: The study included 168 patients with primary HH and 121 age and sex-matched healthy control. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels were compared between HH patients and control group. Results: Of the HH patients included in the study, 41.7% (70) were female and 58.3% (98) were male. Of the patients in the control group, 44.6% (54) were female and 55.4% (67) were male. When HH patients and control groups were compared, the levels of FT3 and FT4 were significantly higher in the HH group, but there was no significant difference between the patient and control groups in terms of TSH levels. The patient and control groups were divided into subgroups according to gender and evaluated. While only FT3 was significantly higher in male patients with HH than in control group, FT3 and FT4 levels were significantly higher in female patients with HH than in the control group. Conclusion: In this study, FT3 and FT4 hormones were associated with HH. If supported by new studies on this subject, in primary HH patients keeping the thyroid hormones close to the lower limit may be considered as a treatment option.

Keywords: Hyperhidrosis; hyperthyroidism; sweating; triiodothyronine; thyroxine
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