Turkiye Klinikleri Journal of Dermatology

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Primer Kutanöz Difüz Büyük B Hücreli Lenfoma Olgusu: Mevcut Sınıflamalar Eşliğinde Primer Kutanöz B Hücreli Lenfomaların Gözden Geçirilmesi
Primary Cutaneous Diffuse Large B Cell Lymphoma: A Case Presentation and the Review of Primary Cutaneous B-Cell Lymphoma Classifications
Fatma Arzu KILIÇa, Sinan ÖZÇELİKa, Rana BAŞARAa, Banu LEBEb, Sermin ÖZKALb, Berna ATEŞAĞAOĞLUc
aDeri ve Zührevi Hastalıkları ABD, Balıkesir Üniversitesi Tıp Fakültesi, Balıkesir, TÜRKİYE
bPatoloji ABD, Dokuz Eylül Üniversitesi Tıp Fakültesi, İzmir, TÜRKİYE
cHematoloji Kliniği, Balıkesir Devlet Hastanesi, Balıkesir, TÜRKİYE
Turkiye Klinikleri J Dermatol. 2019;29(3):131-7
doi: 10.5336/dermato.2019-64812
Article Language: TR
Full Text
ÖZET
 B hücreli lenfomalar, lenf nodlarında ortaya çıkan non-Hodgkin lenfomaların büyük çoğunluğunu oluşturmalarına karşın, primer kutanöz lenfomaların az bir kısmını oluşturur. Primer kutanöz lenfomalar farklı klinik görünüm, histopatoloji, immünfenotip özellikler gösteren heterojen bir grup hastalıktır. Primer kutanöz B hücreli lenfomalar, tüm kutanöz lenfomaların %20-25'ini oluşturmaktadır. 'Primer kutanöz difüz büyük B hücreli lenfoma, diğer tip' oldukça nadir görülen bir kutanöz lenfoma olup, literatürde sınırlı sayıda olgu bildirilmiştir. Tanı kriterlerinin olmaması ve sınıflandırma kriterlerinin karışık/belirsiz olması nedeniyle hastalar yanlış veya geç tanı alabilmektedirler. Bu olgu sunumunda, primer kutanöz B hücreli lenfomaların oldukça nadir görülen bu tipini ayırıcı tanıda akla gelmesini vurgulamak amacıyla sunmak istedik.

Anahtar Kelimeler: B hücreli lenfoma; difüz büyük B hücreli lenfoma; deri neoplazmları
ABSTRACT
 B-cell lymphoma is the most common non-Hodgkin's lymphoma which arise in lymph nodes, but on the other hand, it comprises only a small fraction of primary cutaneous lymphomas. Primary cutaneous lymphomas are a heterogeneous group of diseases with different clinical features, histopathology and immunophenotypes. Primary cutaneous lymphomas represent 20-25% of all cutaneous lymhomas. "Primary cutaneous diffuse large B cell lymphoma, other type" is a very rare primary cutaneous lymphoma and so far, only a limited number of cases have been reported in the literature. Patients might be misdiagnosed or diagnosed late because of the vague classification criteria of the disease and/or the absence of diagnostic criteria. We would like to present this case with this rare subtype of primary cutaneous B-cell lymphoma in order to emphasize that this disease should be considered in the differential diagnosis.

Keywords: B cell lymphoma; diffuse large B cell lymphoma; skin neoplasms
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