Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Prevalence of Hepatitis B, Hepatitis C, Syphilis and HIV Infections in Patients with Anogenital Warts: A Descriptive Cross-Sectional Study
Anogenital Siğilli Hastalarda Hepatit B, Hepatit C, Sifiliz ve HIV Enfeksiyonlarının Sıklığı: Tanımlayıcı Kesitsel Bir Çalışma
Münevver GÜVENa , Gizem ÇETİNKAYAa
aAydın Adnan Menderes University Faculty of Medicine, Department of Dermatology, Aydın, Türkiye
Turkiye Klinikleri J Dermatol. 2024;34(1):16-21
doi: 10.5336/dermato.2023-100147
Article Language: EN
Full Text
ABSTRACT
 Objective: There are limited studies on the frequency of other sexually transmitted diseases in patients with anogenital warts (AGWs). In this study, we aimed to evaluate the frequency of hepatitis B, hepatitis C, syphilis and human immunodeficiency virus (HIV) infections in patients with AGWs. Material and Methods: The data of the patients with AGWs, who applied to our dermatology outpatient clinic between January 2015 and December 2021, were analyzed retrospectively. Serological test results for hepatitis B, hepatitis C, syphilis and HIV infections of patients with AGWs were evaluated. Results: Of 765 patients with AGWs, 541 were male and 224 were female. Among 313 patients who underwent hepatitis B surface antigen (HBsAg) testing, HBsAg positivity was detected in 5 (1.6%) patients. Hepatitis C virus antibody (anti-HCV) positivity was detected in 4 (1.2%) of 324 patients who underwent anti-HCV testing. Four (1.3%) of 298 patients who underwent rapid plasma reagin (RPR) for syphilis were positive (RPR titers 1/2, 1/4, 1/16, and 1/128). Treponema pallidum hemagglutination assay (TPHA) test was negative in 2 patients. The diagnosis of syphilis was confirmed by TPHA test in 2 patients whose RPR titers were 1/16 and 1/128. Among 344 patients who underwent HIV antibody (anti-HIV) testing, anti-HIV positivity was detected in 16 (4.7%) patients. It was later uncovered that 13 of 16 patients were HIV-infected patients who had been already followed by infectious diseases specialists. Confirmation test for HIV infection was negative in 2 patients and positive in 1 patient. As a result, 14 HIV-positive patients were detected. Conclusion: The patients with AGWs should be evaluated for other sexually transmitted diseases, especially syphilis and HIV infection.

Keywords: Genital warts; hepatitis; human immunodeficiency virus; sexually transmitted diseases; syphilis
ÖZET
 Amaç: Anogenital siğilleri olan hastalarda eşlik eden diğer cinsel yolla bulaşan enfeksiyonların sıklığı hakkında çalışmalar sınırlıdır. Bu çalışmada, anogenital siğilleri olan hastalarda hepatit B, hepatit C, sifiliz ve insan immün yetmezlik virüsü [human immunodeficiency virus (HIV)] enfeksiyonu sıklığının değerlendirmesi amaçlanmıştır. Gereç ve Yöntemler: Ocak 2015-Aralık 2021 tarihleri arasında dermatoloji polikliniğimize başvuran anogenital siğilli hastaların verileri retrospektif olarak incelendi. Hastaların hepatit B, hepatit C, sifiliz ve HIV enfeksiyonuna yönelik yapılmış serolojik test sonuçları değerlendirildi. Bulgular: Anogenital siğil tanılı 765 hastanın 541'i erkek, 224'ü kadındı. Hepatit B yüzey antijen tetkiki yapılmış 313 hastanın 5'inin (%1,6) testi pozitif olarak sonuçlandı. Hepatit C virüsü antikoru tetkiki yapılmış olan 324 hastanın 4'ünün (%1,2) testi pozitif olarak saptandı. Sifiliz için hızlı plazma kazanımı [rapid plasma reagin (RPR)] bakılan 298 hastanın 4'ünde (%1,3) pozitiflik (1/2, 1/4, 1/16 ve 1/128 titrelerde) bulundu. RPR titrasyonu 1/2 ve 1/4 gelen 2 hastanın treponema pallidum hemaglütinasyon testi [treponema pallidum hemagglutination assay (TPHA)] negatif olarak sonuçlandı. RPR titrasyonu 1/16 ve 1/128 gelen 2 hastanın TPHA ile sifiliz tanısı doğrulandı. HIV antikoru [HIV antibody (anti-HIV)] testi yapılan 344 hastanın 16'sının (%4,7) testi pozitifti. Anti-HIV testi pozitif çıkan 16 hastanın 13'ünün enfeksiyon hastalıklarından takipli HIV pozitif hastalar olduğu ortaya çıktı. Diğer 3 hastanın ise 2'sinin doğrulama testi negatif olarak sonuçlandı. Bir hasta ise doğrulama testinin pozitif sonuçlanması ile HIV enfeksiyonu tanısı aldı. Sonuç olarak 14 HIV pozitif hasta tespit edildi. Sonuç: Anogenital siğilleri olan hastalar, özellikle sifiliz ve HIV gibi cinsel yolla bulaşan diğer hastalıklar açısından değerlendirilmelidir.

Anahtar Kelimeler: Genital siğiller; hepatit; insan immün yetmezlik virüsü; cinsel yolla bulaşan hastalıklar; sifiliz
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