Objective: Consanguineous marriage (CM) is a common practice in Türkiye. This cross-sectional study was conducted between 2020-2022 to determine the prevalence, current awareness, and perspective of CM and its relationship with socio-demographic and obstetric risk factors in Gaziantep, Türkiye. Material and Methods: A survey was developed that included a total of 35 questions and face-to-face interviews were conducted. A total of 1,007 married participants, 589 women and 418 men, aged 18-82 were included in the study. Results: The CM frequency was 30%, of which 24% were among fourth-degree relatives. Participants living in a nuclear family with low education level first marriage ages were low, perceived economic status was poor and had higher frequencies of CM (p<0.001). Spontaneous miscarriage, stillbirth, and a history of congenital abnormality were higher in CM than in those without CM (p<0.05). The primary reasons for individuals choosing CM were love (45%), family pressure (11%), traditional approaches (23%), and avoiding marrying outside the family (14%). Ninety-two percent of the participants were aware of the health hazards associated with CM including Down syndrome (50%), and congenital heart anomalies (33%). Fourteen percent of the participants found the number of centers providing genetic counseling services in our country sufficient. Conclusion: Despite the high percentage of participant awareness of the potential health defects related to CM, there continues to be a high percentage of CM; therefore, it is crucial to develop working strategies to prevent CM in Gaziantep, Türkiye.
Keywords: Awareness; consanguineous marriages; consanguinity; Gaziantep
Amaç: Akraba evliliği (AE) Türkiye'de yaygın bir uygulamadır. Bu kesitsel çalışma, 2020-2022 yılları arasında Türkiye'nin Gaziantep ilinde AE'nin yaygınlığını, güncel farkındalığını ve bakış açısını ve bunların sosyodemografik ve obstetrik risk faktörleriyle ilişkisini belirlemek amacıyla yapılmıştır. Gereç ve Yöntemler: Toplam 35 sorudan oluşan bir anket geliştirilmiş ve yüz yüze görüşmeler yapılmıştır. Araştırmaya yaşları 18-82 arasında değişen 589'u kadın, 418'i erkek olmak üzere toplam 1.007 evli katılımcı dâhil edildi. Bulgular: AE sıklığı %30 olup, bunların %24'ü dördüncü derece akrabalardaydı. Eğitim düzeyi düşük, çekirdek ailede yaşayan katılımcıların ilk evlenme yaşları düşük, algılanan ekonomik durumları kötü ve AE frekansları daha yüksektir (p<0,001). Kendiliğinden düşük, ölü doğum ve doğuştan anormallik öyküsü; AE olanlarda, AE olmayanlara göre daha yüksektir (p<0,05). Bireylerin AE'yi tercih etmelerinin başlıca nedenleri arasında; sevgi (%45), aile baskısı (%11), geleneksel yaklaşım (%23) ve aile dışında evlenmekten kaçınma (%14) yer almıştır. Katılımcıların %92'si, Down sendromu (%50) ve konjenital kalp anomalileri (%33) dâhil olmak üzere AE ile ilişkili sağlık tehlikelerinin farkındadır. Katılımcıların %14'ü ülkemizde genetik danışmanlık hizmeti veren merkez sayısını yeterli bulmuştur. Sonuç: Katılımcıların AE ile ilgili olası sağlık kusurları konusundaki farkındalıklarının yüksek olmasına rağmen AE frekansı yüksek olmaya devam etmektedir. Bu nedenle, Türkiye'nin Gaziantep şehrinde AE'yi önlemeye yönelik çalışma stratejilerinin geliştirilmesi büyük önem taşımaktadır.
Anahtar Kelimeler: Farkındalık; akraba evlilikleri; akrabalık; Gaziantep
- Joseph N, Pavan KK, Ganapathi K, Apoorva P, Sharma P, Jhamb JA. Health awareness and consequences of consanguineous marriages: a community-based study. J Prim Care Community Health. 2015;6(2):121-7. [Crossref] [PubMed]
- Hamamy H, Jamhawi L, Al-Darawsheh J, Ajlouni K. Consanguineous marriages in Jordan: why is the rate changing with time? Clin Genet. 2005;67(6):511-6. [Crossref] [PubMed]
- Bener A, Abdulrazzaq YM, al-Gazali LI, Micallef R, al-Khayat AI, Gaber T. Consanguinity and associated socio-demographic factors in the United Arab Emirates. Hum Hered. 1996;46(5):256-64. [Crossref] [PubMed]
- Iqbal S, Zakar R, Fischer F, Zakar MZ. Consanguineous marriages and their association with women's reproductive health and fertility behavior in Pakistan: secondary data analysis from Demographic and Health Surveys, 1990-2018. BMC Womens Health. 2022;22(1):118. [Crossref] [PubMed] [PMC]
- Bittles AH. A community genetics perspective on consanguineous marriage. Community Genet. 2008;11(6):324-30. [Crossref] [PubMed]
- Bittles AH, Black ML. Evolution in health and medicine Sackler colloquium: consanguinity, human evolution, and complex diseases. Proc Natl Acad Sci USA. 2010;107 Suppl 1(Suppl 1):1779-86. [Crossref] [PubMed] [PMC]
- Zakar R, Zakar MZ, Aqil N. Adverse birth outcomes associated with consanguineous marriage in Pakistan. Int J Gynaecol Obstet. 2014;127(2):211-2. [Crossref] [PubMed]
- Kelmemi W, Chelly I, Kharrat M, Chaabouni-Bouhamed H. Consanguinity and homozygosity among tunisian patients with an autosomal recessive disorder. J Biosoc Sci. 2015;47(6):718-26. [Crossref] [PubMed]
- Rasool IG, Zahoor MY, Ahmed I, Iqbal M, Shafqat S, Anjum AA, et al. Description of novel variants in consanguineous Pakistani families affected with intellectual disability. Genes Genomics. 2023;45(4):457-65. [Crossref] [PubMed]
- Bittles AH, Grant JC, Sullivan SG, Hussain R. Does inbreeding lead to decreased human fertility? Ann Hum Biol. 2002;29(2):111-30. [Crossref] [PubMed]
- Almazroua AM, Alsughayer L, Ababtain R, Al-Shawi Y, Hagr AA. The association between consanguineous marriage and offspring with congenital hearing loss. Ann Saudi Med. 2020;40(6):456-61. [Crossref] [PubMed] [PMC]
- Bennett RL, Motulsky AG, Bittles A, Hudgins L, Uhrich S, Doyle DL, et al. Genetic counseling and screening of consanguineous couples and their offspring: recommendations of the national society of genetic counselors. J Genet Couns. 2002;11(2):97-119. [Crossref] [PubMed]
- Teeuw ME, Loukili G, Bartels EA, ten Kate LP, Cornel MC, Henneman L. Consanguineous marriage and reproductive risk: attitudes and understanding of ethnic groups practising consanguinity in Western society. Eur J Hum Genet. 2014;22(4):452-7. [Crossref] [PubMed] [PMC]
- Dos Santos CMA, Heller AH, Pena HB, Pena SDJ. A Protocol for preconceptional screening of consanguineous couples using whole exome sequencing. Front Genet. 2021;12:685123. [Crossref] [PubMed] [PMC]
- Koç İ, Eryurt MA. The causal relationship between consanguineous marriages and infant mortality in Turkey. J Biosoc Sci. 2017;49(4):536-55. Erratum in: J Biosoc Sci. 2017;49(4):556. [Crossref] [PubMed]
- Koc I. Prevalence and sociodemographic correlates of consanguineous marriages in Turkey. J Biosoc Sci. 2008;40(1):137-48. [Crossref] [PubMed]
- Koç İ. Türkiye'de akraba evliliklerinin yaygınlığının değişimi ve dirençli grupların belirlenmesi: 2018 Türkiye Nüfus ve Sağlık Araştırması'ndan evlilik kuşaklarına göre analizler [Determining the changes in the prevalence of consanguineous marriages and resistant Groups in Turkey: Analyses by marriage cohorts from the 2018 Turkish Demographic and Health Survey]. Turk J Public Health. 2022;20(3):423-38. [Crossref]
- Bittles AH, Hussain R. An analysis of consanguineous marriage in the Muslim population of India at regional and state levels. Ann Hum Biol. 2000;27(2):163-71. [Crossref] [PubMed]
- Vardi-Saliternik R, Friedlander Y, Cohen T. Consanguinity in a population sample of Israeli Muslim Arabs, Christian Arabs and Druze. Ann Hum Biol. 2002;29(4):422-31. [Crossref] [PubMed]
- Hussain R. Community perceptions of reasons for preference for consanguineous marriages in Pakistan. J Biosoc Sci. 1999;31(4):449-61. [Crossref] [PubMed]
- El Mouzan MI, Al Salloum AA, Al Herbish AS, Qurachi MM, Al Omar AA. Consanguinity and major genetic disorders in Saudi children: a community-based cross-sectional study. Ann Saudi Med. 2008;28(3):169-73. [Crossref] [PubMed] [PMC]
- Mahboub SM, Alsaqabi AA, Allwimi NA, Aleissa DN, Al-Mubarak BA. Prevalence and pattern of consanguineous marriage among educated married individuals in Riyadh. J Biosoc Sci. 2020;52(5):768-75. [Crossref] [PubMed]
- Albanghali MA. Prevalence of Consanguineous Marriage among Saudi Citizens of Albaha, a Cross-Sectional Study. Int J Environ Res Public Health. 2023;20(4):3767. [Crossref] [PubMed] [PMC]
- Kanaan ZM, Mahfouz R, Tamim H. The prevalence of consanguineous marriages in an underserved area in Lebanon and its association with congenital anomalies. Genet Test. 2008;12(3):367-72. [Crossref] [PubMed]
- Akkaya S. Rate of Parental Consanguineous marriage among patients with visual impairments in Turkey. Med Hypothesis Discov Innov Ophthalmol. 2016;5(4):115-20. [PubMed] [PMC]
- Sahin E, İnciser Paşalak Ş, Seven M. Consanguineous marriage and its effect on reproductive behavior and uptake of prenatal screening. J Genet Couns. 2020;29(5):849-56. [Crossref] [PubMed]
- Kaplan S, Pinar G, Kaplan B, Aslantekin F, Karabulut E, Ayar B, et al. The prevalence of consanguıneous marriages and affecting factors ın Turkey: a national survey. J Biosoc Sci. 2016;48(5):616-30. [Crossref] [PubMed]
- Alper OM, Erengin H, Manguoğlu AE, Bilgen T, Cetin Z, Dedeoğlu N, et al. Consanguineous marriages in the province of Antalya, Turkey. Ann Genet. 2004;47(2):129-38. [Crossref] [PubMed]
- Yüksel Ş, Kutlubay A, Karaoğlu L, Yoloğlu S. The prevalence of consanguineous marriages in the city of Malatya, Turkey. Turk J Med Sci. 2009;39(1):133-7. [Crossref]
- Akbayram S, Sari N, Akgün C, Doğan M, Tuncer O, Caksen H, et al. The frequency of consanguineous marriage in eastern Turkey. Genet Couns. 2009;20(3):207-14. [PubMed]
- Sharma SK, Kalam MA, Ghosh S, Roy S. Prevalence and determinants of consanguineous marriage and its types in India: evidence from the National Family Health Survey, 2015-2016. J Biosoc Sci. 2021;53(4):566-76. [Crossref] [PubMed]
- Assaf S, Khawaja M. Consanguinity trends and correlates in the Palestinian Territories. J Biosoc Sci. 2009;41(1):107-24. [Crossref] [PubMed]
- Mohamed M, Tellez J, Bergmann C, Gale DP, Sayer JA, Olinger E. Pseudodominant Alport syndrome caused by pathogenic homozygous and compound heterozygous COL4A3 splicing variants. Ann Hum Genet. 2022;86(3):145-52. [Crossref] [PubMed]
- Romdhane L, Mezzi N, Hamdi Y, El-Kamah G, Barakat A, Abdelhak S. Consanguinity and Inbreeding in Health and Disease in North African Populations. Annu Rev Genomics Hum Genet. 2019;20:155-79. [Crossref] [PubMed]
- Singer S, Davidovitch N, Abu Fraiha Y, Abu Freha N. Consanguinity and genetic diseases among the Bedouin population in the Negev. J Community Genet. 2020;11(1):13-9. [Crossref] [PubMed] [PMC]
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