Osteoartrit

Osteoartritte Kök Hücre Uygulaması
Application of Stem Cells in Osteoarthritis
İdris Şevki KÖKENa, Can EYİGÖRb
aEge Üniversitesi Tıp Fakültesi, Nöroloji ABD, İzmir, TÜRKİYE
bEge Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon ABD, Algoloji BD, İzmir, TÜRKİYE
Köken İŞ, Eyigör C. Osteoartritte kök hücre uygulaması. Hepgüler AS, editör. Osteoartrit. 1. Baskı. Ankara: Türkiye Klinikleri; 2020. p.91-5.
Article Language: TR
ÖZET
Osteoartrit (OA) en sık görülen kronik romatizmal hastalık olup, eklem kıkırdağının bozulması nedeniyle eklem semptomlarına yol açan, eklem kenarlarında yeni kemik formasyonları ile karakterize bir hastalıktır. Osteoartritte tedavinin ana hedefi ağrının azaltılması, fonksiyonelliğin yeniden kazanılması ve sonuç olarak yaşam kalitesinin artışıdır. Kas-iskelet sistemi yaralanmaları bağlamında rejeneratif tıp, hasarlı dokuyu onarmak veya yenilemek için potansiyel terapötik çözümler sunan geniş bir terimdir. Kas iskelet sistemi sorunlarında rejeneratif tıp uygulamaları içerisinde proloterapi, trombositten zengin plazma ve mezenkimal kök hücre tedavileri yer almaktadır. Mezenkimal kök hücreler yüksek farklılaşma yeteneğine ve düşük immünojeniteye sahip olması özellikleriyle rejeneratif tıbbın çok çeşitli alanlarında kullanılabilmektedir. Konvansiyonel tedavilerle yeterli klinik sonuç alınamayan hastalarda, rejeneratif kök hücre tedavileri eklem kıkırdak rejenerasyonunda büyük umut vaat etmektedir. Sonuç olarak, adipoz kaynaklı kök hücreler, düşük immünojeniklikleri ve daha kolay elde edilmeleri nedeniyle kemik iliği kaynaklı kök hücrelere ve otolog kondrositlere ideal bir alternatif gibi görünmektedir.

Anahtar Kelimeler: Osteoartrit; rejeneratif tıp; abdominal yağ; erişkin kök hücreler
ABSTRACT
Osteoarthritis (OA) is the most common chronic rheumatic disease and is characterized by new bone formation at the joint margins, leading to joint symptoms due to the impairment of joint cartilage. The main goal of treatment in osteoarthritisis reducing pain, restoring the functionality and thus improving quality of life. Regenerative medicine in the context of musculoskeletal injuries is a comprehensive term that offers potential therapeutic solutions to restore or repair the damaged tissue. In musculoskeletal problems, regenerative medicine procedures include prolotherapy, platelet-rich plasma and mesenchymal stem cell therapies. Mesenchymal stem cells can be used in a widerange of regenerative medicine with their high differentiation ability and low immunogenicity. Regenerative stem cell therapies show promise for the regeneration of articular cartilage in patients with inadequate clinical results following conventional therapies. In conclusion, adipose-derived stem cells seem to be alternative to bone marrow-derived stem cells and autologous chondrocytes, due to their low immunogenicity, and easier to obtain.

Keywords: Osteoarthritis; regenerative medicine; abdominal fat; adult stem cells

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