Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Oral Mukozit Tedavisine Yönelik Deneysel Bir Formülasyona Bağlı Diş Minesinde Oluşan Renklenmenin Spektrofotometrik Analizi: İn Vitro Çalışma
Spectrophotometric Analysis of the Discoloration of Tooth Enamel Induced by an Experimental Formulation in Oral Mucositis: In Vitro Study
Çiğdem ELBEK ÇUBUKÇUa , Zeynep Ceren ÇELİKb , Sevde Gül BATMAZc
aBursa Uludağ Üniversitesi Diş Hekimliği Fakültesi, Pedodonti ABD, Bursa, Türkiye
bBursa Uludağ Üniversitesi Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi ABD, Bursa, Türkiye
cÇukurova Üniversitesi Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi ABD, Adana, Türkiye
Turkiye Klinikleri J Dental Sci. 2023;29(2):352-7
doi: 10.5336/dentalsci.2022-93738
Article Language: TR
Full Text
ÖZET
 Amaç: Baş-boyun radyoterapisi ve kemoterapi süresince hastalara önerilen koruyucu ağız bakım protokolleri arasında iyileşmeyi destekleyici ve/veya hızlandırıcı birçok farklı bitkisel ekstrakt formülasyonları bulunmaktadır. Bu çalışmanın amacı, oral mukozit tedavisinin desteklenmesi amacıyla üretilen deneysel bir formülasyonun (DF) diş minesi üzerindeki renklendirici etkisini araştırmaktır. Gereç ve Yöntemler: Yirmi sekiz adet çürüksüz üst keser dişin labial yüzeyinden elde edilen 2x2x1 mm büyüklüğündeki mine örnekleri DF (n=7), saf propolis (%6) (n=7), klorheksidin (%0,2 klorheksidin glukonat) (n=7) ve yapay tükürük (kontrol grubu) (n=7) solüsyonlarında T1:12 saat, T2:24 saat olmak üzere bekletildi. Başlangıç ile T1 ve T2 bekletme süreleri sonunda örneklerin renk ölçümleri spektrofotometre cihazıyla (Vita Easy Shade Compact, Bad Sackingen, Almanya) yapıldı. Renk değişimleri CIEDE2000 formülüne göre hesaplandı. Verilerin istatistiksel analizinde tek yönlü varyans analizi ve eşleştirilmiş t-testi kullanıldı. Bulgular: DF uygulanan diş minesi yüzeylerinin ΔE00 değerleri (ortalama±standart sapma) T1 ve T2 için sırasıyla 5,54±2,39 ve 5,61±2,74 şeklinde kaydedilmiştir. DF'nin ΔE00 değerleri, saf propolis ve klorheksidin solüsyonları ile karşılaştırıldığında sayısal olarak daha düşük bulunmuştur (p>0,05). Gruplar arasında renklenme değerleri bakımından anlamlı bir farklılık bulunmamıştır. Sonuç: Oral mukozitin tedavisinde kullanılan propolis içerikli bitkisel formülasyonlar diş minesinde klinik olarak kabul edilemez renk değişikliklerine neden olabilmektedir. Propolis içerikli DF'nin klinik koşullardaki renklendirici etkisinin belirlenebilmesi için ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler: Propolis; diş renklenmesi; oral mukozit
ABSTRACT
 Objective: There are many different herbal extract formulations in supportive treatment of oral mucositis induced by head and neck radiotherapy and chemotherapy. The aim of this study is to investigate the discoloration effect of an experimental formulation (EF) developed and produced for the supportive treatment of oral mucositis on tooth enamel. Material and Methods: Enamel samples of 2x2x1 mm in size obtained from the labial surface of 28 caries-free maxillary insicor samples. Samples were immersed in EF (n=7), pure propolis (6%) (n=7), chlorhexidine (0.2% chlorhexidine gluconate) (n=7) and artificial saliva (control group) (n=7) at T1:12 h and T2:24 h time periods. The color measurements of the samples were performed with a spectrophotometer device (Vita Easy Shade Compact, Bad Sackingen, Germany®) at the beginning and the end of T1 and T2 immersing periods. Color changes were calculated according to the CIEDE2000 formula. One-way variance analysis and paired t-test were used for statistical analysis. Results: The mean ΔE00 values (mean±standard deviation) of enamel surfaces immersed in EF were recorded as 5.54±2.39 and 5.61±2.74 for T1 and T2, respectively. EF has presented numerically lower ΔE00 values compared to pure propolis and chlorhexidine solutions. There was no statistically significant difference between the groups in terms of discoloration effect. Conclusion: Herbal formulations containing propolis used in the supportive treatment of oral mucositis may cause clinically unacceptable color changes on tooth enamel. Further studies are needed to determine any discoloration effect of propolis-containing EF in clinical conditions.

Keywords: Propolis; tooth discoloration; oral mucositis
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