Turkiye Klinikleri Journal of Medical Sciences

.: REVIEW
New Coronavirus (2019-nCoV/COVID-19) and Vitamin C
Yeni Koronavirüs (2019-nCoV/COVID-19) ve Vitamin C
Ayşe TOPAL HANÇERa, Pınar YILMAZa, Meryem YILMAZa
aSivas Cumhuriyet University Faculty of Health Sciences, Department of Nursing, Sivas, TURKEY
Turkiye Klinikleri J Med Sci. 2020;40(2):260-4
doi: 10.5336/medsci.2020-76024
Article Language: EN
Full Text
ABSTRACT
 For the first time in December 2019, a case of pneumonia of unknown etiology was reported in Wuhan, China. Then, in addition to China and on the basis of increasing incidence and mortality rates in other international countries, the global emergency health status was declared by the World Health Organization Emergency Committee, and a new coronavirus was reported.Due to the very high contagion rate of the new Coronavirus (COVID-19), it has affected and continues to affect quite a lot of people from all age groups in the world. General clinical signs of COVID-19 are high fever, cough, nasal congestion, dyspnea, myalgia, fatigue, upper and lower respiratory tract infection and diarrhea. The most important and fatal clinical sign of the virus has been described as pneumonia. Unfortunately, no vaccine or special antiviral drug has been developed against COVID-19 yet. Therefore, the purpose of this review is to examine whether intravenous vitamin C administration is a promising method for the COVID-19 pandemic in accordance with the most recent evidence. Using vitamin C to prevent or treat diseases is often classified in complementary and alternative medicine. For this reason, it should never prevent the actual treatment. Studies have found that high doses of vitamin C reduce lung damage in COVID-19 and other flu infections. Therefore, intravenous vitamin C administration may be useful in addition to COVID-19 treatment.There is a need for high-level clinical studies on the effect of Vitamin C administration on COVID-19.

Keywords: COVID-19; 2019-nCoV; the pandemic; vitamin C; pneumonia; acut respiratory distress syndrome
ÖZET
 İlk kez, 2019 yılı aralık ayında, Çin'in Wuhan şehrinde, etiyolojisi bilinmeyen bir pnömoni vakası bildirilmiştir. Daha sonra Çin'e ek olarak ve diğer uluslararası ülkelerde artan vaka ve ölüm oranlarına dayanarak, Dünya Sağlık Örgütü Acil Durum Komitesi tarafından, küresel acil sağlık durumu ilan edilmiş ve bu duruma yeni bir koronavirüsün neden olduğu bildirilmiştir. Yeni Koronavirüsün (COVID-19) bulaşıcılık hızının çok yüksek olması nedeni ile dünya üzerinde her yaş grubundan oldukça fazla insanı etkilemiş ve etkilemeye devam etmektedir. COVID-19'un genel klinik belirtileri yüksek ateş, öksürük, burun tıkanıklığı, dispne, miyalji, yorgunluk, üst-alt solunum yolu infeksiyonu ve diyaredir. Virüsün en önemli ve ölümcül seyreden klinik belirtisi ise, pnömoni olarak tanımlanmıştır. Ne yazık ki COVID-19'a karşı henüz herhangi bir aşı veya özel antiviral bir ilaç geliştirilmemiştir. Bu nedenle bu derlemenin amacı en güncel kanıtlar doğrultusunda intravenöz vitamin C uygulamasının COVID-19 pandemisi için umut verici bir yöntem olup olmadığının irdelenmesidir. Hastalıkları önlemek veya tedavi etmek için vitamin C kullanımı genellikle tamamlayıcı ve alternatif tıp olarak sınıflandırılmaktadır. Bu nedenle asla asıl tedavinin önüne geçmemelidir. Yapılan çalışmalarda COVID-19 ve diğer gribal enfeksiyonlarda yüksek doz vitamin C akciğer hasarını azalttığı bulunmuştur. Bu nedenle COVID-19 tedavisine ek olarak intravenöz vitamin C uygulaması yararlı olabilir.Vitamin C uygulamasının COVID-19 üzerindeki etkisine yönelik kanıt düzeyi yüksek klinik çalışmalara gereksinim vardır.

Anahtar Kelimeler: COVID-19; 2019-nCoV; pandemik; vitamin C; pnömoni; akut respiratuar distres sendromu
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