Turkiye Klinikleri Journal of Pediatrics

.: ORIGINAL RESEARCH
Miyopik Anizometropik Ambliyopili Çocuklarda Retina Tabakalarının Optik Koherens Tomografi Segmentasyon Analizi ile Değerlendirilmesi
Assessment of Retinal Layers in Children with Myopic Anisometropic Amblyopia via Optical Coherence Tomography Segmentation Analysis
İrfan DURUKANa
aEra Göz Hastanesi, Göz Kliniği, Ankara, TÜRKİYE
Turkiye Klinikleri J Pediatr. 2021;30(1):56-62
doi: 10.5336/pediatr.2020-75244
Article Language: TR
Full Text
ÖZET
 Amaç: Miyopik anizometropik ambliyopili çocuklarda, spektral domain optik koherens tomografi (SD-OKT) cihazı ile retina tabakalarını değerlendirmek ve ambliyopik gözlerle normal gözleri karşılaştırmak. Gereç ve Yöntemler: İleriye dönük kesitsel tipteki bu çalışmada, ayrıntılı bir oftalmolojik muayeneyi takiben miyopik anizometropik ambliyopisi olan pediatrik olguların her 2 gözü, SD-OKT cihazı ile değerlendirildi. Merkezî makula kalınlığı (MMK) analizini takiben, ganglion hücre tabakası, iç pleksiform tabaka, iç nükleer tabaka, dış pleksiform tabaka, dış nükleer tabaka ve retina pigment epiteli tabakasına ait ortalama kalınlıklar kaydedildi. Retinal katmanlar, ayrıca iç ve dış retina katmanlar olmak üzere 2 katmana ayrılarak analiz edildi. Bulgular: Miyopik anizometropik ambliyopisi olan pediatrik olguların 23 (%56,1)'ü kız, 18 (%43,9)'i erkek, ortalama yaşı 11,6±3,0 (minimum 6-maksimum 18) yıl olarak hesaplandı. Ortalama MMK, ambliyopik gözlerde 235,50±10,15 (minimum 218-maksimum 295) μm, normal gözlerde ise 249,25±11,35 (minimum 220-maksimum 301) μm olarak ölçüldü. Ambliyopik gözlerde MMK'nin, normal gözlere kıyasla istatistiksel anlamlı düzeyde ince olduğu saptandı (p<0,001). İncelenen retina tabakalarından sadece ganglion hücre tabakası kalınlığının ambliyopik gözlerde, normal gözlere kıyasla istatistiksel anlamlı düzeyde farklı olduğu görüldü (p=0,015). Sonuç: Miyopik anizometropik ambliyopisi olan pediatrik olgularda, ambliyopik gözlerde, normal gözlere kıyasla merkezî makulanın ve ganglion hücre tabakası kalınlığının anlamlı düzeyde incelmiş olduğu saptanmıştır.

Anahtar Kelimeler: Ambliyopi; anizometropi; optik koherens tomografi; miyopi
ABSTRACT
 Objective: To evaluate the retinal layers via spectral domain optical coherence tomography (SD-OCT) device in children with myopic anisometropic amblyopia and to compare the amblyopic eyes with normal eyes. Material and Methods: In this prospective, cross-sectional study, after a detailed ophthalmological examination, both eyes of the paediatric subjects with myopic anisometropic amblyopia were assessed via SD-OCT device. Following the analysis of central macular thickness (CMT), the mean thicknesses of ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer and retinal pigment epithelium layer were recorded. The retinal layers were further divided into 2 layers as iner and outer retinal layers. Results: The mean age of 23 (56.1%) female and 18 (43.9%) male children with myopic anisometropic amblyopia was 11.6±3.0 (minimum 6-maximum 18) years. The mean CMT was 235.50±10.15 (minimum 218-maximum 295) μm in amblyopic eyes and 249.25±11.35 (minimum 220-maximum 301) μm in normal eyes. In amblyopic eyes, the CMT was found to be statistically significantly thinner in amblyopic eyes than normal eyes (p<0.001). Of the investigated retinal layers, only the ganglion cell layer thickness was statistically significantly different in the amblyopic eyes compared to normal eyes (p=0.015). Conclusion: In pediatric cases with myopic anisometropic amblyopia, it was found that the central macular and ganglion cell layer thicknesses were significantly thinned in amblyopic eyes compared to normal eyes.

Keywords: Amblyopia; anisometropia; optical coherence tomography; myopia
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