Metabolik sendrom (MetS), çeşitli biyokimyasal ve fizyolojik faktörlerin varlığında morbidite ve mortalite riskini artırmaktadır. MetS'in kendi ve komponentlerinin pek çok hastalıkla yakın etkileşimine dair kanıtlar mevcuttur. Tedavisinde hayat tarzı değişikliği ve farmakolojik yöntemler önerilmektedir. Göz hastalıkları arasında en sık yaşa bağlı makula dejenerasyonu ile ilişkisi çalışılmış olsa da diğer göz hastalıkları ile ilişkisini inceleyen araştırmalar da mevcuttur. MetS'in tanınması ve hastalık-risk ilişkisinin aydınlatılması çok sayıda hastalığın gelişme riskinin azaltılabilmesi açısından yakın gelecekte son derece önemli olacaktır. Bu kısa derlemede, MetS tanımlanmış ve göz hastalıkları ile olan ilişkisine ait mevcut verilerin tartışılması amaçlanmıştır.
Anahtar Kelimeler: Diyabet; glokom; hipertansiyon; katarakt; metabolik sendrom; yaşa bağlı makula dejenerasyonu
Metabolic syndrome (MetS) increases the risk of morbidity and mortality in the presence of various biochemical and physiological factors. Lifestyle modification and pharmacological methods have been proposed in the treatment. There is evidence about the close interaction between MetS and/or its components and many diseases. Even though the majority of the researches investigated the relation between MetS and age-related macular degeneration, there have been many studies inquiring its relationship with other eye diseases. Identification of MetS and elucidation of risk-disease correlation will be mandatory in respect with risk reduction for many diseases in near future. In this mini-review, MetS is described and current data regarding its relationship with eye diseases were discussed.
Keywords: Diabetes; glaucoma; hypertension; cataract; metabolic syndrome; age-related macular degeneration
- Kylin E. [Studien ueber das hypertonie-hyperglyca ?mie-hyperurika? miesyndrom]. Zentralblatt fuer Innere Medizin. 1923;44:105-27.
- Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med. 1989;149(7):1514-20. [Crossref]
- Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes. 1992;41(6):715-22. [Crossref][PubMed]
- Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract. 2014;2014: 943162. [Crossref][PubMed][PMC]
- Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120 (16):1640-5. [Crossref][PubMed]
- Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome--a new worldwide definition. Lancet. 2005;366(9491):1059-62. [Crossref]
- Olijhoek JK, van der Graaf Y, Banga JD, Algra A, Rabelink TJ, Visseren FL; SMART Study Group. The metabolic syndrome is associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial disease or abdominal aortic aneurysm. Eur Heart J. 2004;25(4):342-8. [Crossref][PubMed]
- Desroches S, Lamarche B. The evolving definitions and increasing prevalence of the metabolic syndrome. Appl Physiol Nutr Metab. 2007;32(1):23-32. [Crossref] [PubMed]
- Kolovou GD, Anagnostopoulou KK, Salpea KD, Mikhailidis DP. The prevalence of metabolic syndrome in various populations. Am J Med Sci. 2007;333(6):362-71. [[Crossref][PubMed]
- Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med. 2003;163(4):427-36. [Crossref][PubMed][PMC]
- Ghaem Maralani H, Tai BC, Wong TY, Tai ES, Li J, Wang JJ, et al. Metabolic syndrome and risk of age-related cataract over time: an analysis of interval-censored data using a random-effects model. Invest Ophthalmol Vis Sci. 2013;54(1):641-6. [Crossref] [PubMed]
- Tan JS, Mitchell P, Smith W, Wang JJ. Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology. 2007;114(6):1143-50. [Crossref] [PubMed]
- Kawashima M, Uchino M, Yokoi N, Dogru M, Uchino Y, Komuro A, et al. Decreased tear volume in patients with metabolic syndrome: the Osaka study. Br J Ophthalmol. 2014;98(3):418-20. [Crossref] [PubMed][PMC]
- Tang YL, Cheng YL, Ren YP, Yu XN, Shentu XC. Metabolic syndrome risk factors and dry eye syndrome: a meta-analysis. Int J Ophthalmol. 2016;9(7):1038-45.
- Newman-Casey PA, Talwar N, Nan B, Musch DC, Stein JD. The relationship between components of metabolic syndrome and open-angle glaucoma. Ophthalmology. 2011; 118(7):1318-26. [Crossref][PubMed][PMC]
- Wolf S, Arend O, Sponsel WE, Schulte K, Cantor LB, Reim M. Retinal hemodynamics using scanning laser ophthalmoscopy and hemorheology in chronic open-angle glaucoma. Ophthalmology. 1993;100(10):1561-6. [Crossref]
- Zhao D, Cho J, Kim MH, Friedman DS, Guallar E. Diabetes, fasting glucose, and the risk of glaucoma: a meta-analysis. Ophthalmology. 2015;122(1):72-8. [Crossref] [PubMed]
- Sato T, Roy S. Effect of high glucose on fibronectin expression and cell proliferation in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2002;43(1):170-5.
- Oh SW, Lee S, Park C, Kim DJ. Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome. Diabetes Metab Res Rev. 2005;21(5):434-40. [Crossref] [PubMed]
- Doughty MJ, Zaman ML. Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol. 2000;44(5):367-408. [Crossref]
- Pfeiffer N, Torri V, Miglior S, Zeyen T, Adamsons I, Cunha-Vaz J; European Glaucoma Prevention Study Group. Central corneal thickness in the European Glaucoma Prevention Study. Ophthalmology. 2007; 114(3):454-9. [Crossref] [PubMed]
- Su DH, Wong TY, Wong WL, Saw SM, Tan DT, Shen SY, et al; Singapore Malay Eye Study Group. Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. Ophthalmology. 2008; 115(6):964-8.e1.
- Nakamura M, Kanamori A, Negi A. Diabetes mellitus as a risk factor for glaucomatous optic neuropathy. Ophthalmologica. 2005;219(1):110. [Crossref] [PubMed]
- Park BJ, Park JO, Kang HT, Lee YJ. Elevated intraocular pressure is associated with metabolic syndrome in postmenopausal women: the Korean National Health and Nutrition Examination Survey. Menopause. 2013;20(7):742-6. [Crossref][PubMed]
- Chang YC, Lin JW, Wang LC, Chen HM, Hwang JJ, Chuang LM. Association of intraocular pressure with the metabolic syndrome and novel cardiometabolic risk factors. Eye (Lond). 2010;24(6):1037-43. [Crossref][PubMed]
- Kim HA, Han K, Lee YA, Choi JA, Park YM. Differential association of metabolic risk factors with open angle glaucoma according to obesity in a Korean population. Sci Rep. 2016;6:38283. [Crossref] [PubMed][PMC]
- Zarei R, Anvari P, Eslami Y, Fakhraie G, Mohammadi M, Jamali A, et al. Retinal nerve fibre layer thickness is reduced in metabolic syndrome. Diabet Med. 2017;34(8):1061-6. [Crossref][PubMed]
- Ghaem Maralani H, Tai BC, Wong TY, Tai ES, Li J, Wang JJ, et al. Metabolic syndrome and risk of age-related macular degeneration. Retina. 2015;35(3):459-66. [Crossref][PubMed]
- Klein R, Deng Y, Klein BE, Hyman L, Seddon J, Frank RN, et al. Cardiovascular disease, its risk factors and treatment, and age-related macular degeneration: Women?s Health Initiative Sight Exam ancillary study. Am J Ophthalmol. 2007;143(3):473-83. [Crossref][PubMed][PMC]
- Seddon JM, Gensler G, Milton RC, Klein ML, Rifai N. Association between C-reactive protein and age-related macular degeneration. JAMA. 2004;291(6):704-10. [Crossref][PubMed]
- Hidayat AA, Fine BS. Diabetic choroidopathy. Light and electron microscopic observations of seven cases. Ophthalmology. 1985;92(4): 512-22. [Crossref]
- Fryczkowski AW, Sata SE, Hodes BL. Changes in the diabetic choroidal vasculature: scanning electron microscopy findings. Ann Ophthalmol. 1988;20(8):299-305.
- Friedman E. The role of the atherosclerotic process in the pathogenesis of age-related macular degeneration. Am J Ophthalmol. 2000;130(5):658-63. [Crossref]
- Noda K, Nakao S, Zandi S, Sun D, Hayes KC, Hafezi-Moghadam A. Retinopathy in a novel model of metabolic syndrome and type 2 diabetes: new insight on the inflammatory paradigm. FASEB J. 2014;28(5):2038-46. [Crossref][PubMed][PMC]
- Godisela KK, Reddy SS, Kumar CU, Saravanan N, Reddy PY, Jablonski MM, et al. Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome. Mol Vis. 2017;23:263-74.
- Zhao Y, Yang K, Wang F, Liang Y, Peng Y, Shen R, et al. Associations between metabolic syndrome and syndrome components and retinal microvascular signs in a rural Chinese population: the Handan Eye Study. Graefes Arch Clin Exp Ophthalmol. 2012; 250(12):1755-63. [Crossref] [PubMed]
- Wang SB, Mitchell P, Plant AJ, Phan K, Liew G, Thiagalingam A, et al. Metabolic syndrome and retinal microvascular calibre in a high cardiovascular disease risk cohort. Br J Ophthalmol. 2016;100(8):1041-6. [Crossref][PubMed]
- Thierry M, Pasquis B, Acar N, Grégoire S, Febvret V, Buteau B, et al. Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat. PLoS One. 2014;9(11):e112450. [Crossref][PubMed][PMC]
- Peeters A, Magliano DJ, Stevens J, Duncan BB, Klein R, Wong TY. Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study. Arch Ophthalmol. 2008;126(11):1554-60. [Crossref] [PubMed][PMC]
- Vine AK, Stader J, Branham K, Musch DC, Swaroop A. Biomarkers of cardiovascular disease as risk factors for age-related macular degeneration. Ophthalmology. 2005;112(12):2076-80. [Crossref] [PubMed]
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