Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Karbodimidin Universal Adezivlerin Dentine Bağlanma Kuvveti Üzerine Etkisi: İn-Vitro Bir Çalışma
Effect of Carbodiimide on the Dentin Bond Strength of Universal Adhesives: An In-Vitro Study
Ayşe Nur DOĞANa, Soley ARSLANb
aNimet Bayraktar Ağız ve Diş Sağlığı Hastanesi, Restoratif Diş Tedavisi Kliniği, Kayseri, Türkiye
bErciyes Üniversitesi Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi ABD, Kayseri, Türkiye
Turkiye Klinikleri J Dental Sci. 2023;29(1):166-75
doi: 10.5336/dentalsci.2022-91090
Article Language: TR
Full Text
ÖZET
 Amaç: Bu in vitro çalışmanın amacı, matriksmetalloproteinaz inhibitörü olan karbodimidin (1-etil-3-[3-dimetilaminopropil] carbodiimide) adeziv uygulaması öncesi dentin yüzey tedavisinde kullanıldığında universal adeziv sistemlerin dentine bağlanma dayanımı üzerine etkisinin mikrogerilim test yöntemiyle değerlendirilmesidir. Gereç ve Yöntemler: Bu araştırmada, 80 tane insan 3. molar dişten standart dentin yüzeyleri elde edilmiş ve rastgele 8 gruba ayrılmıştır. Grupların yarısına 1M karbodimid ile adeziv uygulaması öncesi yüzey tedavisi yapılırken, diğer yarısına uygulanmamıştır. Daha sonra bütün gruplara Single Bond Universal ve Clearfil Universal Bond hem etchand- rinse hem self-etch modunda kullanılarak uygulanmıştır. Örneklerin hepsi 4 mm kalınlığında 3M Filtek Bulk-Fill kompozit rezinle restore edilerek polimerize edilmiştir. Örnekler 24 saat distile suda bekletildikten sonra her grubun yarısı 6 ay yapay tükürükte saklanmıştır. Her örnekten 1 mm2lik yirmişer kesit alındıktan sonra mikrogerilim bağlanma dayanımı testi yapılmıştır. Mikrogerilim bağlanma dayanımı verilerini analiz etmek için hem 3 yönlü hem de tek yönlü varyans analizi ve 'post hoc' Tukey testi kullanılmıştır. Bulgular: Araştırma sonuçlarına göre test edilen erken dönem grupların mikrogerilim bağlanma dayanımı değerleri arasında istatistiksel olarak anlamlı farklılıklar bulunmazken (p>0,05), geç dönem grupların mikrogerilim bağlanma dayanımı değerleri arasında istatistiksel olarak anlamlı farklılıklar olduğu görülmüştür (p<0,05). Tüm grupların erken ve geç dönem bağlanma dayanımı değerleri arasında istatistiksel olarak anlamlı farklılıklar bulunmamıştır (p>0,05). Single Bond Universal'ın kullanıldığı grupların hepsi, Clearfil Universal Bond'un kullanıldığı gruplardan istatistiksel olarak anlamlı şekilde daha yüksek bağlanma dayanımı göstermişlerdir (p<0,05). Sonuç: Karbodimid kullanılan grupların erken ve geç dönem bağlanma değerleri arasında fark bulunmamıştır.

Anahtar Kelimeler: Dentine bağlanma dayanımı; biyoyıkım; karbodimid; matriksmetalloproteinaz; universal adezivler
ABSTRACT
 Objective: The aim of this in-vitro study is to evaluate the effect of universal adhesive systems on dentin bond strength by microtensile test method when carbodiimide (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide), which is a matrix metalloproteinase inhibitor, is used in dentin surface treatment before adhesive application. Material and Methods: In this study, standard dentin surfaces were obtained from 80 human 3. molar teeth and randomly divided into 8 groups. Half of the groups were treated with 1M carbodimide before the adhesive application, while the other half did not. Then, Single Bond Universal and Clearfil Universal Bond were applied to all groups using either etch-and-rinse or self-etch modes. All samples were restored and polymerized with 4 mm thick 3M Filtek Bulk-Fill composite resin. After the samples were kept in distilled water for 24 hours, half of each group was stored in artificial saliva for 6 months. After taking 20 sections of 1 mm2 from each sample, microtensile bond strength test was performed. Three-way and one-way analysis of variance and post hoc Tukey test were used to analyze microtensile bond strength data. Results: According to the results of the study, while there was no statistically significant difference between the microtensile bond strength values of the tested early period groups (p>0.05), there were statistically significant differences between the microtensile bond strength values of the late period groups (p<0.05). There was no statistically significant difference between the early and late bond strength values of all groups (p>0.05). All of the groups in which Single Bond Universal was used showed significantly higher bond strength than the groups in which Clearfil Universal Bond was used (p<0.05). Conclusion: While there was no difference between the early and late bonding values of the groups in which carbodimide was used, an increase was observed in the bonding values of the groups in which Single Bond Universal was applied.

Keywords: Dentin bond strength; biodegradation; carbodimide; matrix metalloproteinase; universal adhesives
REFERENCES:
  1. Hanabusa M, Mine A, Kuboki T, Momoi Y, Van Ende A, Van Meerbeek B, et al. Bonding effectiveness of a new 'multi-mode' adhesive to enamel and dentine. J Dent. 2012;40(6):475-84. [Crossref]  [PubMed] 
  2. Breschi L, Mazzoni A, Ruggeri A, Cadenaro M, Di Lenarda R, De Stefano Dorigo E. Dental adhesion review: aging and stability of the bonded interface. Dent Mater. 2008;24(1):90-101. [Crossref]  [PubMed] 
  3. Van Meerbeek B, Yoshihara K, Yoshida Y, Mine A, De Munck J, Van Landuyt KL. State of the art of self-etch adhesives. Dent Mater. 2011;27(1):17-28. [Crossref]  [PubMed] 
  4. Liu Y, Tjäderhane L, Breschi L, Mazzoni A, Li N, Mao J, et al. Limitations in bonding to dentin and experimental strategies to prevent bond degradation. J Dent Res. 2011;90(8):953-68. [Crossref]  [PubMed]  [PMC] 
  5. Nishitani Y, Yoshiyama M, Wadgaonkar B, Breschi L, Mannello F, Mazzoni A, et al. Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives. Eur J Oral Sci. 2006;114(2):160-6. [Crossref]  [PubMed] 
  6. De Munck J, Van den Steen PE, Mine A, Van Landuyt KL, Poitevin A, Opdenakker G, et al. Inhibition of enzymatic degradation of adhesive-dentin interfaces. J Dent Res. 2009;88(12):1101-6. [Crossref]  [PubMed] 
  7. Tjäderhane L, Nascimento FD, Breschi L, Mazzoni A, Tersariol IL, Geraldeli S, et al. Strategies to prevent hydrolytic degradation of the hybrid layer-A review. Dent Mater. 2013;29(10):999-1011. [Crossref]  [PubMed]  [PMC] 
  8. Bedran-Russo AK, Pashley DH, Agee K, Drummond JL, Miescke KJ. Changes in stiffness of demineralized dentin following application of collagen crosslinkers. J Biomed Mater Res B Appl Biomater. 2008;86(2):330-4. [Crossref]  [PubMed] 
  9. Cova A, Breschi L, Nato F, Ruggeri A Jr, Carrilho M, Tjäderhane L, et al. Effect of UVA-activated riboflavin on dentin bonding. J Dent Res. 2011;90(12):1439-45. [Crossref]  [PubMed]  [PMC] 
  10. Bedran-Russo AK, Vidal CM, Dos Santos PH, Castellan CS. Long-term effect of carbodiimide on dentin matrix and resin-dentin bonds. J Biomed Mater Res B Appl Biomater. 2010;94(1):250-5. [Crossref]  [PubMed]  [PMC] 
  11. Ekambaram M, Yiu CK, Matinlinna JP. Effect of solvents on dentin collagen cross-linking potential of carbodiimide. J Adhes Dent. 2015;17(3):219-26. [PubMed] 
  12. Scheffel DL, Hebling J, Scheffel RH, Agee KA, Cadenaro M, Turco G, et al. Stabilization of dentin matrix after cross-linking treatments, in vitro. Dent Mater. 2014;30(2):227-33. [Crossref]  [PubMed]  [PMC] 
  13. Singh P, Nagpal R, Singh UP. Effect of dentin biomodifiers on the immediate and long-term bond strengths of a simplified etch and rinse adhesive to dentin. Restor Dent Endod. 2017;42(3):188-99. [Crossref]  [PubMed]  [PMC] 
  14. Blake-Haskins JC, Mellberg JR, Snyder C. Effect of calcium in model plaque on the anticaries activity of fluoride in vitro. J Dent Res. 1992;71(8):1482-6. [Crossref]  [PubMed] 
  15. Mazzoni A, Angeloni V, Apolonio FM, Scotti N, Tjäderhane L, Tezvergil-Mutluay A, et al. Effect of carbodiimide (EDC) on the bond stability of etch-and-rinse adhesive systems. Dent Mater. 2013;29(10):1040-7. [Crossref]  [PubMed] 
  16. Tezvergil-Mutluay A, Mutluay MM, Agee KA, Seseogullari-Dirihan R, Hoshika T, Cadenaro M, et al. Carbodiimide cross-linking inactivates soluble and matrix-bound MMPs, in vitro. J Dent Res. 2012;91(2):192-6. [Crossref]  [PubMed]  [PMC] 
  17. Bedran-Russo AK, Pereira PN, Duarte WR, Drummond JL, Yamauchi M. Application of crosslinkers to dentin collagen enhances the ultimate tensile strength. J Biomed Mater Res B Appl Biomater. 2007;80(1):268-72. [Crossref]  [PubMed] 
  18. Singh P, Nagpal R, Singh UP, Manuja N. Effect of carbodiimide on the structural stability of resin/dentin interface. J Conserv Dent. 2016;19(6):501-9. [Crossref]  [PubMed]  [PMC] 
  19. Scheffel DL, Delgado CC, Soares DG, Basso FG, de Souza Costa CA, Pashley DH, et al. Increased durability of resin-dentin bonds following cross-linking treatment. Oper Dent. 2015;40(5):533-9. [Crossref]  [PubMed]  [PMC] 
  20. Mazzoni A, Angeloni V, Comba A, Maravic T, Cadenaro M, Tezvergil-Mutluay A, et al. Cross-linking effect on dentin bond strength and MMPs activity. Dent Mater. 2018;34(2):288-95. [Crossref]  [PubMed] 
  21. Hashimoto M, Fujita S, Nagano F, Ohno H, Endo K. Ten-years degradation of resin-dentin bonds. Eur J Oral Sci. 2010;118(4):404-10. [Crossref]  [PubMed] 
  22. Chen C, Niu LN, Xie H, Zhang ZY, Zhou LQ, Jiao K, et al. Bonding of universal adhesives to dentine--Old wine in new bottles? J Dent. 2015;43(5):525-36. [Crossref]  [PubMed] 
  23. McLean DE, Meyers EJ, Guillory VL, Vandewalle KS. Enamel bond strength of new universal adhesive bonding agents. Oper Dent. 2015;40(4):410-7. [Crossref]  [PubMed] 
  24. Yoshida Y, Yoshihara K, Nagaoka N, Hayakawa S, Torii Y, Ogawa T, et al. Self-assembled Nano-layering at the Adhesive interface. J Dent Res. 2012;91(4):376-81. [Crossref]  [PubMed] 
  25. Perdigão J, Kose C, Mena-Serrano AP, De Paula EA, Tay LY, Reis A, et al. A new universal simplified adhesive: 18-month clinical evaluation. Oper Dent. 2014;39(2):113-27. [Crossref]  [PubMed] 
  26. Loguercio AD, de Paula EA, Hass V, Luque-Martinez I, Reis A, Perdigão J. A new universal simplified adhesive: 36-Month randomized double-blind clinical trial. J Dent. 2015;43(9):1083-92. [Crossref]  [PubMed] 
  27. Rosa WL, Piva E, Silva AF. Bond strength of universal adhesives: A systematic review and meta-analysis. J Dent. 2015;43(7):765-76. [Crossref]  [PubMed] 
  28. Marchesi G, Frassetto A, Mazzoni A, Apolonio F, Diolosà M, Cadenaro M, et al. Adhesive performance of a multi-mode adhesive system: 1-year in vitro study. J Dent. 2014;42(5):603-12. [Crossref]  [PubMed] 
  29. Scherrer SS, Cesar PF, Swain MV. Direct comparison of the bond strength results of the different test methods: a critical literature review. Dent Mater. 2010;26(2):e78-93. [Crossref]  [PubMed] 
  30. Durmuşlar S, Ölmez A. Microtensile bond strength and failure modes of flowable composites on primary dentin with application of different adhesive strategies. Contemp Clin Dent. 2017;8(3):373-9. [Crossref]  [PubMed]  [PMC] 

.: Up To Date

.: Process List

Login

 Forgot your password?

 New Registration  

Contact

Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş.

.: Address

Turkocagi Caddesi No:30 06520 Balgat / ANKARA
Phone: +90 312 286 56 56
Fax: +90 312 220 04 70
E-mail: info@turkiyeklinikleri.com

.: Manuscript Editing Department

Phone: +90 312 286 56 56/ 2
E-mail: yaziisleri@turkiyeklinikleri.com

.: English Language Redaction

Phone: +90 312 286 56 56/ 145
E-mail: tkyayindestek@turkiyeklinikleri.com

.: Marketing Sales-Project Department

Phone: +90 312 286 56 56/ 142
E-mail: reklam@turkiyeklinikleri.com

.: Subscription and Public Relations Department

Phone: +90 312 286 56 56/ 118
E-mail: abone@turkiyeklinikleri.com

.: Customer Services

Phone: +90 312 286 56 56/ 118
E-mail: satisdestek@turkiyeklinikleri.com

1. TERMS OF USE

1.1. To use the web pages with http://www.turkiyeklinikleri.com domain name or the websites reached through the sub domain names attached to the domain name (They will be collectively referred as "SITE"), please read the conditions below. If you do not accept these terms, please cease to use the "SITE." "SITE" owner reserves the right to change the information on the website, forms, contents, the "SITE," "SITE" terms of use anytime they want.

1.2. The owner of the "SITE" is Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. (From now on it is going to be referred as "Turkiye Klinikleri", shortly) and it resides at Turkocagi cad. No:30, 06520 Balgat Ankara. The services in the "SITE" are provided by "Turkiye Klinikleri."

1.3. Anyone accessing the "SITE" with or without a fee whether they are a natural person or a legal identity is considered to agree these terms of use. In this contract hereby, "Turkiye Klinikleri" may change the stated terms anytime. These changes will be published in the "SITE" periodically and they will be valid when they are published. Any natural person or legal identity benefiting from and reaching to the "SITE" are considered to be agreed to any change on hereby contract terms done by "Turkiye Klinikleri."

1.4. The "Terms of Use" hereby is published in the website with the last change on March 30th 2014 and the "SITE" is activated by enabling the access to everyone. The "Terms of Use" hereby is also a part of the any "USER Contract" was and/or will be done with the users using "Turkiye Klinikleri" services with or without a fee an inseparable.

2. DEFINITIONS

2.1. "SITE": A website offering different kind of services and context with a certain frame determined by "Turkiye Klinikleri" and it is accessible on-line on http://www.turkiyeklinikleri.com domain name and/or subdomains connected to the domain name.

2.2. USER: A natural person or a legal identity accessing to the "SITE" through online settings.

2.3. LINK: A link enabling to access to another website through the "SITE", the files, the context or through another website to the "SITE", the files and the context.

2.4. CONTEXT: Any visual, literary and auditory images published in the "Turkiye Klinikleri", "SITE" and/or any website or any accessible information, file, picture, number/figures, price, etc.

2.5. "USER CONTRACT": An electronically signed contract between a natural or a legal identity benefiting from special services "Turkiye Klinikleri" will provide and "Turkiye Klinikleri".

3. SCOPE OF THE SERVICES

3.1. "Turkiye Klinikleri" is completely free to determine the scope and quality of the services via the "SITE".

3.2. To benefit the services of "Turkiye Klinikleri" "SITE", the "USER" must deliver the features that will be specified by "Turkiye Klinikleri". "Turkiye Klinikleri" may change this necessity any time single-sided.

3.3. Not for a limited number, the services "Turkiye Klinikleri" will provide through the "SITE" for a certain price or for free are;

- Providing scientific articles, books and informative publications for health industry.

- Providing structural, statistical and editorial support to article preparation stage for scientific journals.

4. GENERAL PROVISIONS

4.1. "Turkiye Klinikleri" is completely free to determine which of the services and contents provided in the "SITE" will be charged.

4.2. People benefiting from the services provided by "Turkiye Klinikleri" and using the website can use the "SITE" only according to the law and only for personal reasons. Users have the criminal and civil liability for every process and action they take in the "SITE". Every USER agrees, declares and undertakes that they will not proceed by any function or action infringement of rights of "Turkiye Klinikleri"s and/or other third parties', they are the exclusive right holder on usage, processing, storage, made public and revealing any written, visual or auditory information reported to Turkiye Klinikleri" and/or "SITE" to the third parties. "USER" agrees and undertakes that s/he will not duplicate, copy, distribute, process, the pictures, text, visual and auditory images, video clips, files, databases, catalogs and lists within the "SITE", s/he will not be using these actions or with other ways to compete with "Turkiye Klinikleri", directly or indirectly.

4.3. The services provided and the context published within the "SITE" by third parties is not under the responsibility of "Turkiye Klinikleri", institutions collaborated with "Turkiye Klinikleri", "Turkiye Klinikleri" employee and directors, "Turkiye Klinikleri" authorized salespeople. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any third party are under the full responsibility of the third party. "Turkiye Klinikleri" does not promise and guarantee the safety, accuracy and legality of the services and context provided by a third party.

4.4. "USER"s cannot act against "Turkiye Klinikleri", other "USER"s and third parties by using the "SITE". "Turkiye Klinikleri" has no direct and/or indirect responsibility for any damage a third party suffered or will suffer regarding "USER"s actions on the "SITE" against the rules of the hereby "Terms of Use" and the law.

4.5. "USER"s accept and undertake that the information and context they provided to the "SITE" are accurate and legal. "Turkiye Klinikleri" is not liable and responsible for promising and guaranteeing the verification of the information and context transmitted to "Turkiye Klinikleri" by the "USER"s, or uploaded, changed and provided through the "SITE" by them and whether these information are safe, accurate and legal.

4.6. "USER"s agree and undertake that they will not perform any action leading to unfair competition, weakening the personal and commercial credit of "Turkiye Klinikleri" and a third party,  encroaching and attacking on personal rights within the "SITE" in accordance with the Turkish Commercial Code Law.

4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com