Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Investigation of the Efficacy of Hypochlorous Acid as a Postoperative Wound Antiseptic: A Randomized Controlled Pilot Study
Postoperatif Yara Antiseptiği Olarak Hipokloröz Asidin Etkinliğinin İncelenmesi: Randomize Kontrollü Pilot Çalışma
Sema Nur SEVİNÇ GÜLa , Bahtiyar Zana GÜZELa , Dilruba Rana ÇÖGENLİa , Merve PEKİNCE ÖZÖNERb , Alparslan DİLSİZa
aAtatürk University Faculty of Dentistry, Department of Periodontology, Erzurum, Türkiye
bSiirt University Faculty of Medicine, Department of Histology and Embryology, Siirt, Türkiye
Turkiye Klinikleri J Dental Sci. 2025;31(2):233-40
doi: 10.5336/dentalsci.2024-104539
Article Language: EN
Full Text
ABSTRACT
 Objective: This study aims to investigate the effectiveness of hypochlorous acid (HA) as a postoperative wound antiseptic in patients undergoing gingivectomy. Material and Methods: Twenty four patients who were diagnosed with chronic inflammatory gingival overgrowth were included in the study. After the gingivectomy procedure, patients were randomly divided into 3 groups according to the mouthwash they used for postoperative wound care; 1) HA group, 2) Chlorhexidine (CHX) group, 3) Saline (control) group. Records of the operation area were taken at the beginning, on the 1st, 3rd and 7th days. Periodontal indexes, visual analog scale (VAS), hydrogen peroxide (H2O2), plaque staining agent test, and histological analyzes were used to evaluate wound healing. The data were analyzed statistically. Results: The HA and CHX groups were statistically significantly lower than the control group in the plaque index and bleeding on probing values measured on the 7th day (p<0.05). There was no statistically significant difference between groups in VAS and H2O2 test (p>0.05). In the staining agent test, no statistically significant difference was found between control days in all groups and between the groups. In the histological analysis, statistically significantly more keratinocyte cells were found in the HA group than both groups in the samples taken on control days (p<0.05). Conclusion: HA has been histologically proven to support wound healing after periodontal surgery. HA can be recommended as a good alternative to CHX for postoperative wound care.

Keywords: Antiinfective agents; gingival overgrowth; gingivectomy; hypochlorous acid; wound healing
ÖZET
 Amaç: Bu çalışma, gingivektomi yapılan hastalarda postoperatif yara antiseptiği olarak hipokloröz asidin (HA) etkinliğini araştırmayı amaçlamaktadır. Gereç ve Yöntemler: Kronik inflamatuar diş eti büyümesi tanısı alan 24 hasta çalışmaya dâhil edildi. Gingivektomi işlemi sonrasında hastalar postoperatif yara bakımında kullandıkları gargaralara göre rastgele 3 gruba ayrıldı; 1) HA grubu, 2) Klorheksidin [Chlorhexidine (CHX)] grubu, 3) Salin (kontrol) grubu. Başlangıçta, 1, 3 ve 7. günde operasyon bölgesinin kayıtları alındı. Yara iyileşmesini değerlendirmek için periodontal indeksler, görsel analog skala [visual analog scale (VAS)], hydrogen peroxide (H2O2), plak boyayıcı ajan testi ve histolojik analizler kullanıldı. Veriler istatistiksel olarak analiz edildi. Bulgular: Yedinci günde ölçülen plak indeksi ve sondalamada kanama değerlerinde HA ve CHX grupları kontrol grubuna göre istatistiksel olarak anlamlı derecede düşüktü (p<0,05). VAS ve H2O2 testinde gruplar arasında istatistiksel olarak anlamlı fark yoktu (p>0,05). Plak boyama ajanı testinde tüm gruplarda kontrol günleri arasında ve gruplar arasında istatistiksel olarak anlamlı fark bulunamadı (p>0,05). Histolojik analizde kontrol günlerinde alınan örneklerde HA grubunda her iki gruba göre istatistiksel olarak anlamlı düzeyde daha fazla keratinosit hücresi tespit edildi (p<0,05). Sonuç: Periodontal cerrahi sonrası, HA'nın yara iyileşmesini desteklediği histolojik olarak kanıtlanmıştır. Postoperatif yara bakımında CHX iyi bir alternatif olarak HA önerilebilir.

Anahtar Kelimeler: Antienfektif ajanlar; dişeti büyümesi; gingivektomi; hipokloröz asit; yara iyileşmesi
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