Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Investigation of the Effect of Chronic Obstructive Pulmonary Disease on Corneal Transparency and Endothelial Characteristics: Cross-Sectional Study
Kronik Obstrüktif Akciğer Hastalığının Kornea Şeffaflığı ve Endotel Özellikleri Üzerine Etkisinin İncelenmesi: Kesitsel Araştırma
Tuğçe HOROZOĞLU CERANa , Ali Mert KOÇERb , Halil İbrahim ATEŞOĞLUc , Gülden BİLGİNd , Mine TURKAYe , Pınar KÖSEKAHYAb
aUniversity of Health Sciences Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Ophthalmology, Ankara, Türkiye
bUlucanlar Eye Training and Research Hospital, Clinic of Ophthalmology, Ankara, Türkiye
cTatvan State Hospital, Clinic of Ophthalmology, Bitlis, Türkiye
dAnkara Training and Research Hospital, Clinic of Chest Diseases, Ankara, Türkiye
eAnkara Etlik City Hospital, Clinic of Ophthalmology, Ankara, Türkiye
Turkiye Klinikleri J Ophthalmol. 2024;33(2):67-74
doi: 10.5336/ophthal.2023-97834
Article Language: EN
Full Text
ABSTRACT
 Objective: In this study, it was aimed to investigate corneal transparency and endothelial characteristics of patients with chronic obstructive pulmonary disease (COPD) and compare these findings with ageand gender-matched healthy controls. Material and Methods: Forty-nine eyes of 49 patients with COPD (24 females, 25 males) and 65 eyes of 65 healthy controls (36 females, 29 males) were included in this study. Participants were evaluated using Scheimpflug corneal topography (Pentacam HR Oculus, Wetzlar, Germany) and specular biomicroscopy (Tomey, Nagoya, Japan) to obtain measurements of corneal pachymetry, keratometry, and densitometry values with corneal endothelial cell characteristics. Spirometry values [forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC ratio], smoking status (pack-years), and disease duration were recorded in the patient group. Results: Corneal pachymetry and keratometry measurements were statistically similar in the study groups (p>0.05, for all). Although the measurement of endothelial cell count was lower in the patient group, it was not statistically significant (p=0.130). Higher corneal densitometry values were observed in the patient group compared to the control group in all depths and diameters (p<0.05, for all). Numerous corneal densitometry values in the patient group showed significant negative correlations with FVC measurements and positive correlations with smoking status (p<0.05, for all). Conclusion: It can be thought that corneal transparency can decrease throughout the entire cornea due to hypoxia in patients with COPD, and this effect is correlated with smoking status and disease severity. Therefore, patients with COPD should be evaluated carefully before ophthalmological procedures which can affect corneal transparency.

Keywords: Chronic obstructive pulmonary disease; corneal densitometry; corneal endothelium; corneal transparency
ÖZET
 Amaç: Çalışmamızda, kronik obstrüktif akciğer hastalığı (KOAH) olan katılımcılarda kornea şeffaflığının ve endotel özelliklerinin incelenmesi ve bu bulguların yaş ve cinsiyet uyumlu sağlıklı kontroller ile karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmamıza 49 KOAH hastasının (24 kadın, 25 erkek) 49 gözü ve 65 sağlıklı kontrolün (36 kadın, 29 erkek) 65 gözü dâhil edildi. Katılımcılar Scheimpflug korneal topografi cihazı (Pentacam HR Oculus, Wetzlar, Almanya) ve speküler biyomikroskop (Tomey, Nagoya, Japonya) ile değerlendirilerek korneal pakimetri, keratometri ve dansitometri değerleri ile kornea endotel hücre özellikleri elde edildi. Hasta grubunda spirometri değerleri [zorlu vital kapasite (forced vital capacity ''FVC''), birinci sn zorlu ekspirasyon volümleri (forced expiratory volume in 1 second ''FEV1'') ve FEV1/FVC oranı], sigara kullanımı (paket/yıl) ve hastalık süresi kaydedildi. Bulgular: Korneal pakimetri ve keratometri ölçümleri çalışma gruplarında istatistiksel olarak benzerdi (tümü için p˃0,05). Endotel sayısı hasta grubunda daha az olmasına rağmen bu fark istatistiksel olarak anlamlı değildi (p=0,130). Hasta grubunda kontrol grubuna göre tüm derinlik ve çaplarda daha yüksek korneal dansitometri değerleri saptandı (tümü için p˂0,05). Hasta grubundaki çok sayıda korneal dansitometri değeri ile FVC değerleri arasında ters korelasyon izlenirken sigara kullanımı ile pozitif korelasyonlar saptandı (tümü için p˂0,05). Sonuç: KOAH hastalarında hipoksi nedeni ile korneal şeffaflığın tüm kornea boyunca azaldığı ve bu etkinin sigara kullanımı ve hastalık şiddeti ile korele olduğu düşünülmektedir. Bu nedenle KOAH'lı hastaların kornea şeffaflığını etkileyebilecek oftalmik işlemler öncesinde dikkatle değerlendirilmesi gerektiği düşünülmektedir.

Anahtar Kelimeler: Kronik obstrüktif akciğer hastalığı; korneal dansitometri; kornea endoteli; kornea şeffaflığı
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