Journal of Traditional Medical Complementary Therapies

.: ORIGINAL RESEARCH
Investigation of the Antiasthmatic Effects of Zufa Jewheri Used in Traditional Uyghur Medicine: An Experimental Study
Geleneksel Uygur Tıbbında Kullanılan Zufa Cevheri'nin Antiastmatik Etkilerinin Araştırılması: Deneysel Çalışma
Fidan PESEN ÖZDOĞANa , Fatma UYSALb , Mağfiret ABDULVELİ BOZLARc , Saliha Ayşenur ÇAM ÖZÜNLÜb , Gülben AKCANd , Seyfullah Oktay ARSLANb
aUniversity of Health Science, Hamidiye Institute of Health Science, Department of Traditional and Complementary Medicine, İstanbul, Türkiye
bAnkara Yıldırım Beyazıt University Faculty of Medicine, Department of Pharmacology, Ankara, Türkiye
cUniversity of Health Science Hamidiye Faculty of Medicine, Department of Public Health, İstanbul, Türkiye
dAnkara Yıldırım Beyazıt University Faculty of Medicine, Department of Histology and Embryology, Ankara, Türkiye
J Tradit Complem Med. 2024;7(2):162-73
doi: 10.5336/jtracom.2024-102401
Article Language: EN
Full Text
ABSTRACT
 Objective: In this study, the effects of Zufa Jewheri, an aqueous extract of a herbal mixture used in Uyghur medicine, on ovalbumin-induced allergic asthma model in mice were investigated. Gas chromatography-mass spectrometry analysis was performed to detect fatty acids and monoterpenes present in the herbal mixture. Material and Methods: Ovalbumin-sensitized and -challenged BALB/c mice were orally administered varying doses of the herbal mixture and its aqueous extract. The effectiveness of the treatments was evaluated by Penh values, serum and bronchoalveolar lavage fluid (BALF) interleukin (IL)-4 and IL5 levels, serum immunoglobulin E (IgE) levels and histological lung inflammation. Results: Ovalbumin-sensitized mice exhibited increased Penh values, elevated serum and BALF IL-4 and IL-5 levels, increased serum IgE levels and BALF eosinophil, neutrophil, lymphocyte and macrophage counts, and inflammation in lung tissue. Administration of 25 mg/kg of the herbal mixture (ZUFA-25) showed positive effects by significantly decreasing Penh values, serum and BALF IL-4 and IL-5 levels, BALF inflammatory cell counts and lung inflammation. Administration of 125 and 250 mg/kg of the mixture also reduced Penh values, serum and BALF IL4 and IL-5 levels and inflammatory cell levels. Conclusion: This study confirms the traditional use of Zufa Jewheri for asthma. Zufa Jewheri Powder Mixture reduced airway hyperresponsiveness and inflammation in a mouse model of allergic asthma. These findings indicate the potential of Zufa Jewheri as adjunctive therapy for asthma. Further clinical studies in humans are needed to confirm its efficacy and safety.

Keywords: Uyghur medicine; traditional medicine; Zufa Jewheri; allergic asthma
ÖZET
 Amaç: Bu çalışmada, Uygur tıbbında kullanılan bitkisel bir karışımın sulu ekstraktı olan Zufa Cevheri'nin, farelerde ovalbümin ile indüklenen alerjik astım modeli üzerindeki etkileri araştırılmıştır. Gaz kromatografisi-kütle spektrometresi analizi ile bitkisel karışımdaki yağ asitleri ve monoterpenler tanımlanmıştır. Gereç ve Yöntemler: Ovalbümin ile duyarlılaştırılmış ve provoke edilmiş BALB/c farelerine bitkisel karışım ve sulu ekstre değişen dozlarda oral olarak uygulanmıştır. Tedavilerin etkinliği Penh değerleri, serum ve bronkoalveolar lavaj (BAL) sıvısı interlökin (IL)-4 ve IL-5 düzeyleri, serum immünglobulin E (IgE) seviyeleri ve histolojik akciğer inflamasyonu ile değerlendirilmiştir. Bulgular: Ovalbümin ile duyarlılaştırılan farelerde Penh değerlerinde, serum ve BAL sıvısı IL-4 ve IL-5 düzeylerinde, serum IgE seviyelerinde, BAL sıvısı eozinofil, nötrofil, lenfosit ve makrofaj sayılarında ve akciğer dokusu inflamasyon skorlarında artış görüldü. Bitkisel karışımın 25 mg/kg dozda uygulanması (ZUFA-25) Penh değerlerini, serum ve BAL sıvısı IL-4 ve IL-5 düzeylerini, BAL sıvısı inflamatuar hücre sayılarını ve akciğer dokusu inflamasyon skorunu anlamlı olarak azalttı. Karışımın 125 ve 250 mg/kg dozlarında uygulanması da Penh değerlerini, serum ve BALF IL-4 ve IL-5 seviyelerini ve inflamatuvar hücre düzeylerini azalttı. Sonuç: Bu çalışma, Zufa Cevheri'nin astım için geleneksel kullanımını doğrulamaktadır. Zufa Cevheri Toz Karışımı, alerjik astım fare modelinde solunum yolu aşırı duyarlılığını ve inflamasyonunu azaltmıştır. Bu bulgular Zufa Cevheri'nin astım için yardımcı tedavi potansiyeline işaret etmektedir. Etkinliğini ve güvenliğini doğrulamak için insanlarda daha fazla klinik çalışmaya ihtiyaç vardır.

Anahtar Kelimeler: Uygur tıbbı; geleneksel tıp; Zufa Cevheri; alerjik astım
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