Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
Intraocular Pressure and Central Corneal Thickness in Premature Newborns: A Systematic Review with Meta-Analysis
Prematüre Yenidoğanlarda Göz İçi Basıncı ve Merkezi Kornea Kalınlığı: Sistematik Bir İnceleme ve Metaanaliz
Kalina TRIFONOVAa , Kiril SLAVEYKOVb , Hristo MUMDZHIEVc
aDepartment of Ophthalmology and Otorhinolaryngology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
bFirst Department of Internal Diseases and General Medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
cDepartment of Neonatology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Turkiye Klinikleri J Med Sci. 2024;44(2):76-84
doi: 10.5336/medsci.2024-101251
Article Language: EN
Full Text
ABSTRACT
 Objective: Our study aimed to summarize and analyze the available information in the up-to-date literature, concerning intraocular pressure and central corneal thickness values in premature newborns. Material and Methods: We conducted a comprehensive literature review, gathering information from PubMed, Scopus, Embase, Google Scholar, and free-text searches on the topic. We chose only 14 of them to perform a meta-analysis. We used Review Manager 5.4 to compare the mean values of intraocular pressure and central corneal thickness between full-term and premature newborns. Results: The results of the mean value of intraocular pressure of premature infants varied significantly according to different authors-from 10 mmHg to 29 mmHg. Most of the research showed higher intraocular pressure and thicker corneas in premature infants compared to full-term ones. Many researchers looked for a positive correlation between the increased central corneal thickness in premature newborns and the increased intraocular pressure but showed conflicting results. Our meta-analysis showed that the intraocular pressure and central corneal thickness in premature newborns were significantly higher compared to full-term infants with mean difference of 1.95 mmHg [Confidence interval (CI) 0.62-3.28] and 57.82 μm (CI 34.46-81.18), respectively. Conclusion: Additional studies tracking changes in both intraocular pressure and central corneal thickness values, with larger sample sizes and in a longitudinal design with better-differentiated sample groups, are warranted.

Keywords: Preterm; infants; central corneal thickness; intraocular pressure
ÖZET
 Amaç: Çalışmamız, prematüre yenidoğanlarda göz içi basıncı ve merkezi kornea kalınlığı değerleri hakkında güncel literatürde mevcut bilgileri özetlemeyi ve analiz etmeyi amaçlamaktadır. Gereç ve Yöntemler: PubMed, Scopus, Embase, Google Akademik ve konuyla ilgili ücretsiz metin aramalarından bilgiler toplayarak kapsamlı bir literatür incelemesi yürüttük. Yalnızca 14 tanesini metaanaliz yapmak için seçtik. Tam süreli ve prematüre yenidoğanlar arasında göz içi basıncı ve merkezi kornea kalınlığı ortalama değerlerini karşılaştırmak için Review Manager 5.4 programını kullandık. Bulgular: Prematüre bebeklerin göz içi basıncının ortalama değerinin sonuçları, farklı yazarlara göre 10 mmHg ile 29 mmHg arasında önemli ölçüde değişmiştir. Araştırmaların çoğu, prematüre bebeklerde tam zamanında doğanlara kıyasla daha yüksek göz içi basıncı ve daha kalın korneaların olduğunu göstermiştir. Birçok araştırmacı, prematüre yenidoğanlarda artmış merkezi kornea kalınlığı ile artmış göz içi basıncı arasında pozitif bir korelasyon aramış, ancak çelişkili sonuçlar elde etmiştir. Metaanalizimiz, prematüre yenidoğanlarda göz içi basıncının ve merkezi kornea kalınlığının, sırasıyla ortalama 1,95 mmHg [Güven aralığı (GA) 0,62-3,28] ve 57,82 μm (GA 34,46-81,18) fark ile tam zamanında doğan bebeklere göre anlamlı olarak daha yüksek olduğunu göstermiştir. Sonuç: Hem göz içi basıncı hem de merkezi kornea kalınlığı değerlerindeki değişimleri izleyen, daha büyük örneklem boyutlarına ve daha iyi ayrıştırılmış örneklem gruplarıyla uzun süreli bir tasarımda ek çalışmalar yapılması gerekmektedir.

Anahtar Kelimeler: Prematüre; bebekler; merkezi kornea kalınlığı; göz içi basıncı
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