Turkiye Klinikleri Journal of Veterinary Sciences

.: ORIGINAL RESEARCH
İç Anadolu Bölgesi'nde Anti Enfeksiyöz Laringotrakeitis Virüsü Antikor Araştırması: Özgün Araştırma
Anti Infectious Laryngotracheitis Virus Antibody Investigation in the Central Anatolia Region: Original Research
Gülşen GONCAGÜLa, Özlem KARDOĞANb, Elçin GÜNAYDINc, Yavuz ÇOKALd
aBursa Uludağ Üniversitesi Mennan Pasinli Atçılık Meslek Yüksekokulu, Bursa, TÜRKİYE
bVeteriner Kontrol Merkez Araştırma Enstitüsü Müdürlüğü, Kanatlı Hayvan Hastalıkları Teşhis Laboratuvarı, Ankara, TÜRKİYE
cKastamonu Üniversitesi Veteriner Fakültesi, Mikrobiyoloji ABD, Kastamonu, TÜRKİYE d Bandırma Onyedi Eylül Üniversitesi Bandırma Meslek Yüksekokulu, Balıkesir, TÜRKİYE
Turkiye Klinikleri J Vet Sci. 2021;12(2):63-9
doi: 10.5336/vetsci.2021-84120
Article Language: TR
Full Text
ÖZET
 Amaç: Enfeksiyöz laringotrakeitis [infectious laryngotracheitis (ILT)], tüm dünyada kümes hayvanlarının ekonomik açıdan önemli bir viral solunum yolu hastalığıdır. Bu çalışmanın amacı, İç Anadolu Bölgesi'nde ticari yumurtacı sürü ve köy tavuklarında anti-ILT virüsü (ILTV) antikorları varlığını indirekt ELISA ile araştırmaktır. Gereç ve Yöntemler: İç Anadolu Bölgesi'nde 17 aşısız (n=268) ve 11 aşılı (n=465) olmak üzere 28 ticari yumurtacı sürüden (n=733) ve 7 farklı lokalizayonda bulunan köy tavuklarından (n=145) rastgele toplam 878 kan örneği alındı ve serumları çıkartıldı. Serum örneklerinde, ILTV'ye karşı oluşan antikorları tespit etmek için ticari indirekt ELISA kiti ile kullanıldı. Bulgular: İncelenen toplam 145 aşısız köy tavuğunda %86,90 (n=126), 268 aşısız ticari yumurtacıda %90,67 (n=243), 465 aşılı ticari yumurtacıda %35,70 (n=166) oranında anti-ILTV antikorlarına rastlandı. Aşılama yapılmasına rağmen 5 ticari yumurtacı sürüde ILTV'ye karşı antikor tespit edilmedi. Sonuç: İç Anadolu Bölgesi'nde özellikle aşısız ticari yumurtacı sürülerde ve köy tavuklarında ILT enfeksiyonunun ciddi risk yarattığı belirlendi. Kümeslerin birbirine yakınlığı dolayısıyla özellikle aşı kaynaklı saçılımın olabileceği öngörüsüyle, ILT salgınlarından izole edilen suşların filogenetik analizlerinin yapılıp, daha ileri çalışmalarda enfeksiyonun kaynağı üzerine eğilmenin daha doğru bir yaklaşım olacağı kanaatindeyiz.

Anahtar Kelimeler: Enfeksiyöz laringotrakeitis; ELISA; ticari yumurtacı tavuk; köy tavuğu
ABSTRACT
 Objective: Infectious laryngotracheitis (ILT) is an economically important viral respiratory disease of poultry around the world. The aim of this study is investigate the presence of anti-ILTV antibodies in commercial layers and village chickens in the Central Anatolia Region by indirek ELISA. Material and Methods: A total of 878 blood samples were collected from 28 commercial layer flocks (n=733) comprising 17 unvaccinated (n=268), 11 vaccinated (n=465), and village chickens (n=145) at 7 different localisation in the Central Anatolia Region. Sera were obtained from the collected blood samples. Anti-ILT virus (ILTV) antibodies were determined by commercial indirect ELISA kit. Results: Anti-ILTV antibodies were determined of the investigated 145 unvaccinated village chickens, 268 unvaccinated commercial layer chickens, and 465 vaccinated commercial layer chickens, at ratios of 86.90% (n=126), 90.67% (n=243), and 35.70% (n=166), respectively. Although 5 commercial layer flocks were vaccinated, no antibody response was detected. Conclusion: It was determined that ILT infection poses a serious risk especially in unvaccinated commercial layer flocks and village chickens in the Central Anatolia Region. We believe that it would be a more correct approach to conduct phylogenetic analyzes of strains isolated from ILT outbreaks and to focus on the source of infection in further studies, with the prediction of vaccine-induced spillage due to the proximity of the flocks.

Keywords: Infectious laryngotracheitis; ELISA; commercial layer chicken; village chicken
REFERENCES:
  1. Uddin MI, Sen AB, Islam MS, Das S, Sultana N, Ripa RN, et al. Seroepidemiology of infectious laryngotracheitis (ILT) in the commercial layer farms of Chittagong district, Bangladesh. Adv. Anim. Vet. Sci. 2014;2(6):316-20. [Crossref] 
  2. Hidalgo H. Infectious laryngotracheitis: a review. Braz. J. Poult. Sci. 2003;5(3):157-68. [Crossref] 
  3. Kirkpatrick NC, Mahmoudian A, O'Rourke D, Noormohammadi AH. Differentiation of infectious laryngotracheitis virus isolates by restriction fragment length polymorphic analysis of polymerase chain reaction products amplified from multiple genes. Avian Dis. 2006;50(1):28-34. [Crossref]  [PubMed] 
  4. Portz C, Beltrão N, Furian TQ, Júnior AB, Macagnan M, Griebeler J, et al. Natural infection of turkeys by infectious laryngotracheitis virus. Vet Microbiol. 2008;131(1-2):57-64. [Crossref]  [PubMed] 
  5. Jordan FT. Further observations on the epidemiology of infectious laryngo-tracheitis of poultry. J Comp Pathol. 1963;73:253-64. [Crossref]  [PubMed] 
  6. Guy JS, Garcia M. Laryngotracheitis. In: Saif YM, Fadly AM, Glisson JR, McDougald LR, Nolan LK, Swayne DE, eds. Diseases of Poultry. 12th ed. Ames: Blackwell Publishing; 2008. p.137-52.
  7. Tesfaye A, Sahle M, Sori T, Kassa T, Garoma A, Koran T, et al. Infectious laryngotracheitis virus in commercial and backyard chicken production systems in central and south Ethiopia (First report) ILT in Ethiopian Poultry Production. J Appl Poult Res. 2019;28(4):1324-9. [Crossref] 
  8. Sander JE, Thayer SG. Evaluation of ELISA titers to infectious laryngotracheitis. Avian Dis. 1997;41(2):429-32. [Crossref]  [PubMed] 
  9. Rodríguez-Avila A, Oldoni I, Riblet S, García M. Replication and transmission of live attenuated infectious laryngotracheitis virus (ILTV) vaccines. Avian Dis. 2007;51(4):905-11. [Crossref]  [PubMed] 
  10. Beltrán G, Williams SM, Zavala G, Guy JS, García M. The route of inoculation dictates the replication patterns of the infectious laryngotracheitis virus (ILTV) pathogenic strain and chicken embryo origin (CEO) vaccine. Avian Pathol. 2017;46(6):585-93. [Crossref]  [PubMed] 
  11. Coppo MJ, Noormohammadi AH, Browning GF, Devlin JM. Challenges and recent advancements in infectious laryngotracheitis virus vaccines. Avian Pathol. 2013;42(3):195-205. [Crossref]  [PubMed] 
  12. Yan Z, Li S, Xie Q, Chen F, Bi Y. Characterization of field strains of infectious laryngotracheitis virus in China by restriction fragment length polymorphism and sequence analysis. J Vet Diagn Invest. 2016;28(1):46-9. [Crossref]  [PubMed] 
  13. Guy JS, Barnes HJ, Morgan LM. Virulence of infectious laryngotracheitis viruses: comparison of modified-live vaccine viruses and North Carolina field isolates. Avian Dis. 1990;34(1):106-13. [Crossref]  [PubMed] 
  14. Bagust TJ, Johnson MA. Avian infectious laryngotracheitis: virus-host interactions in relation to prospects for eradication. Avian Pathol. 1995;24(3):373-91. [Crossref]  [PubMed] 
  15. Fahey KJ, York JJ. The role of mucosal antibody in immunity to infectious laryngotracheitis virus in chickens. J Gen Virol. 1990;71 ( Pt 10):2401-5. [Crossref]  [PubMed] 
  16. Bauer B, Lohr JE, Kaleta EF. Comparison of commercial ELISA test kits from Australia and the USA with the serum neutralization test in cell cultures for the detection of antibodies to the infectious laryngotracheitis virus of chickens. Avian Pathol. 1999;28(1):65-72. [Crossref]  [PubMed] 
  17. Moreno A, Piccirillo A, Mondin A, Morandini E, Gavazzi L, Cordioli P. Epidemic of infectious laryngotracheitis in Italy: characterization of virus isolates by PCR-restriction fragment length polymorphism and sequence analysis. Avian Dis. 2010;54(4):1172-7. [Crossref]  [PubMed] 
  18. Gowthaman V, Singh SD, Dhama K, Barathidasan R, Mathapati BS, Srinivasan P, et al. Molecular detection and characterization of infectious laryngotracheitis virus (Gallid herpesvirus-1) from clinical samples of commercial poultry flocks in India. Virusdisease. 2014;25(3):345-9. [Crossref]  [PubMed]  [PMC] 
  19. Agnew-Crumpton R, Vaz PK, Devlin JM, O'Rourke D, Blacker-Smith HP, Konsak-Ilievski B, et al. Spread of the newly emerging infectious laryngotracheitis viruses in Australia. Infect Genet Evol. 2016;43:67-73. [Crossref]  [PubMed] 
  20. Gulacti I, Eroksuz Y, Bulut H, Ceribasi AO. Outbreak of clinical infectious laryngotracheitis in Turkey. Vet Rec. 2007;160(16):554-5. [Crossref]  [PubMed] 
  21. Aras Z, Yavuz O, Sanioğlu Gölen G. Occurrence of infectious laryngotracheitis outbreaks in commercial layer hens detected by ELISA. J Immunoassay Immunochem. 2018;39(2):190-5. [Crossref]  [PubMed] 
  22. Roba YT, Tadesse D, Assefa Z, Tesfaye A. Seroprevalence of infectious laryngotracheitis disease in backyard chickens in villages of Ada'a district, Oromia, Ethiopia: first report. Trop Anim Health Prod. 2020;52(6):3109-12. [Crossref]  [PubMed] 
  23. García M, Zavala G. Commercial vaccines and vaccination strategies against ınfectious laryngotracheitis: what we have learned and knowledge gaps that remain. Avian Dis. 2019;63(2):325-34. [Crossref]  [PubMed] 
  24. Menendez KR, García M, Spatz S, Tablante NL. Molecular epidemiology of infectious laryngotracheitis: a review. Avian Pathol. 2014;43(2):108-17. [Crossref]  [PubMed] 
  25. Guy JS, Bagust TJ. Laryngotracheitis. In: Saif YM, Barnes HJ, Glisson JR, Fadly AM, Mcdougald LR, Swayne DE, eds. Diseases of Poultry. 11th ed. Ames: Iowa State University Press; 2003. p.121-34.
  26. Fuchs W, Veits J, Helferich D, Granzow H, Teifke JP, Mettenleiter TC. Molecular biology of avian infectious laryngotracheitis virus. Vet Res. 2007;38(2):261-79. [Crossref]  [PubMed] 
  27. Neff C, Sudler C, Hoop RK. Characterization of western European field isolates and vaccine strains of avian infectious laryngotracheitis virus by restriction fragment length polymorphism and sequence analysis. Avian Dis. 2008;52(2):278-83. [Crossref]  [PubMed] 
  28. Oldoni I, Rodríguez-Avila A, Riblet S, García M. Characterization of infectious laryngotracheitis virus (ILTV) isolates from commercial poultry by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Avian Dis. 2008;52(1):59-63. [Crossref]  [PubMed] 
  29. Williams RA, Bennett M, Bradbury JM, Gaskell RM, Jones RC, Jordan FT. Demonstration of sites of latency of infectious laryngotracheitis virus using the polymerase chain reaction. J Gen Virol. 1992;73 (Pt 9):2415-20. [Crossref]  [PubMed] 
  30. Dufour-Zavala L. Epizootiology of infectious laryngotracheitis and presentation of an industry control program. Avian Dis. 2008;52(1):1-7. [Crossref]  [PubMed] 
  31. Guy JS, Barnes HJ, Smith L. Increased virulence of modified-live infectious laryngotracheitis vaccine virus following bird-to-bird passage. Avian Dis. 1991;35(2):348-55. [Crossref]  [PubMed] 
  32. Rodríguez-Avila A, Oldoni I, Riblet S, García M. Replication and transmission of live attenuated infectious laryngotracheitis virus (ILTV) vaccines. Avian Dis. 2007;51(4):905-11. [Crossref]  [PubMed] 
  33. Bayoumi M, El-Saied M, Amer H, Bastami M, Sakr EE, El-Mahdy M. Molecular characterization and genetic diversity of the infectious laryngotracheitis virus strains circulating in Egypt during the outbreaks of 2018 and 2019. Arch Virol. 2020;165(3):661-70. [Crossref]  [PubMed] 
  34. Molini U, Aikukutu G, Khaiseb S, Kahler B, Van der Westhuizen J, Cattoli G, et al. Investigation of infectious laryngotracheitis outbreaks in Namibia in 2018. Trop Anim Health Prod. 2019;51(7):2105-8. [Crossref]  [PubMed] 
  35. GhalyanchiLangeroudi A, Hosseini H, Fallah MH, Aghaeean L, Esmaeelzadeh Dizaji R, Ziafati Z, et al. Serological Survey of Infectious Laryngotracheitis in Broiler Flocks, Iran, 2018. Iran J Virol. 2020;14(1):1-5. [Link] 

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