Turkiye Klinikleri Journal of Case Reports

How Much Resistance is Considered During Prophylaxis Recommendation? A Case Report of Infective Endocarditis with Multi-Drug Resistant Streptococcus Despite Appropriate Prophylaxis Before Dental Intervention
Emel BAYRAKa, Müberra Devrim GÜNERd, Semra TUNÇBİLEKb, Serpil TAŞDELENc
aLÖSEV LÖSANTE Children and Adults Hospital, Clinic of Internal Diseases, Ankara, TÜRKİYE
bLÖSEV LÖSANTE Children and Adults Hospital, Clinic of Infectious Diseases, Ankara, TÜRKİYE
cLÖSEV LÖSANTE Children and Adults Hospital, Microbiology Laboratory, Ankara, TÜRKİYE
dTOBB Economics and Technology University Faculty of Medicine, Department of Medical Pharmacology, Ankara, TÜRKİYE
Turkiye Klinikleri J Case Rep. 2020;28(1):36-40
doi: 10.5336/caserep.2019-70616
Article Language: EN
Full Text
ABSTRACT
 Infective endocarditis is a disease with high mortality and morbidity, generally caused by a wide range of organisms. Prophylaxis with penicillins, cefalosporins, macrolides, or vancomycin is highly recommended for the patients with endocarditis, prosthetic heart valves. An 83-year-old man admitted with fever, fatigue, and joint pain and reported dental intervention following amoxicillin prophylaxis fortyfive days ago. Patient history indicated acute rheumatoid arthritis, bacterial endocarditis, and mitral and aortic valve replacement. S. Sanguinis was detected in the blood culture of the patient, which was resistant to penicillin and ampicillin. He was given meropenem, the clinical status was improved and no microorganisms were detected in two follow-up blood cultures. Endocarditis prophylaxis should be individualized considering the globally high penicillin resistance, especially for the patients with prosthetic valves and/or infective endocarditis history. In addition, to decrease the bacterial load of the oral flora before elective dental or respiratory intervention is recommended with antibiotic prophylaxis.

Keywords: Infective endocarditis; antibiotic prophylaxis; antibiotic resistance; S. sanguinis
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30.03.2014

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