Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
HLA Type Determination in Patients Diagnosed with Mycosis Fungoides and Sézary Syndrome
Mikozis Fungoides ve Sézary Sendromu Tanısı Alan Hastalarda HLA Tip Tayini
Ali Rıza BAŞARANa, Burhan ENGİNb, Muazzez Çiğdem OBAb, Erkan YILMAZc, Zekayi KUTLUBAYb, Server SERDAROĞLUb
aClinic of Dermatology and Veneorology, Private OFM Antalya Hospital, Antalya, TURKEY
Departments of
bDermatology and Veneorology,
cBlood Bank, Tissue Typing Laboratory, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, İstanbul, TURKEY
Turkiye Klinikleri J Med Sci. 2019;39(1):42-7
doi: 10.5336/medsci.2018-62421
Article Language: EN
Full Text
ABSTRACT
 Objective: Mycosis fungoides (MF) and Sézary syndrome (SS) represent the most frequently encountered subtypes of primary cutaneous T-cell lymphoma. The human leukocyte antigen (HLA) system was shown to be involved in susceptibility to MF/SS in various studies involving populations of different genetic backgrounds. We aimed to determine the possible association of HLA system with MF/SS in Turkish cases. Material and Methods: A total of 30 MF/SS cases underwent genotyping for HLA-A, HLA-B and HLA-DR loci. Samples from 30 healthy subjects were obtained as controls. Results: Statistically significant associations were found between MF and HLA-A31, HLA-B51 and HLA-DR3 alleles. A significantly higher frequency of HLA-B35 and HLADR4 was noted in healthy controls as compared with the patients. Conclusion: This study suggests that HLA genotypes are involved in susceptibility to MF. HLA-A31, HLA-B51 and HLA-DR3 alleles were considered as markers to disease susceptibility whereas HLA-B35 and HLA-DR4 alleles may be protective against neoplastic transformation.

Keywords: Disease susceptibility; HLA antigens; mycosis fungoides
ÖZET
 Amaç: Mikozis fungoides (MF) ve Sézary sendromu (SS) primer T-hücreli deri lenfomalarının en sık rastlanan formlarıdır. Farklı genetik zeminlerden toplumlarda yapılan çeşitli çalışmalarda hastalığın gelişiminde sınıf I ve II insan lökosit antijenlerinin (HLA) rolü olabileceği gösterilmiştir. Çalışmanın amacı, Türk hastalarda mikozis fungoides ve Sézary sendromu ile HLA sisteminin muhtemel ilişkisinin araştırılmasıdır. Gereç ve Yöntemler:Mikozis fungoides ve Sézary sendromu tanısı olan 30 hastaya HLA-A, HLA-B ve HLA-DR lokuslarını değerlendirmek üzere genotipleme yapıldı. Sonuçlar 30 sağlıklı bireyin örnekleri ile karşılaştırıldı. Bulgular: HLA-A31, HLAB51 ve HLA-DR3 alelleri ile MF arasında istatistiksel olarak anlamlı ilişki saptandı. Hastalarla kıyaslandığında, kontrol grubunda HLA-B35 ve HLA-DR4 sıklığında anlamlı yükseklik mevcuttu. Sonuç: Çalışmamız HLA genotiplerinin MF'e yatkınlıkta rolü olabileceğini göstermektedir. HLAA31, HLA-B51 ve HLA-DR3 alelleri hastalığa yatkınlığı göstermekte iken HLA-B35 ve HLA-DR4 alelleri neoplastik dönüşümden koruyucu gibi gözükmektedir.

Anahtar Kelimeler: Hastalığa yatkınlık; HLA antijeni; mikozis fungoides
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