Turkiye Klinikleri Cardiovascular Sciences

.: ORIGINAL RESEARCH
Heart Rate Turbulence Analysis in Healthy Postmenopausal Women
Sağlıklı Postmenopozal Kadınlarda Kalp Hızı Türbülansı Analizi
Cennet YILDIZa, Ahmet KARAKURTb
aDepartment of Perfusion, Kavram Vocational School, İstanbul, TURKEY
bDepartment of Cardiology, Kafkas University Faculty of Medicine, Kars, TURKEY
Turkiye Klinikleri J Cardiovasc Sci. 2021;33(1):1-6
doi: 10.5336/cardiosci.2020-77696
Article Language: EN
Full Text
ABSTRACT
 Objective: The aim of the present study was to investigate heart rate turbulence (HRT) parameters in postmenopausal women. Material and Methods: A total of 40 postmenopausal women and 43 healthy, regularly menstruating premenopausal women were taken as study and control groups, respectively. All patients had biochemical blood examination, 2-D echocardiography and 24-hour Holter monitorization. HRT parameters, namely turbulence onset (TO) and turbulence slope (TS) were calculated. Results: Age, body mass index (BMI), systolic and diastolic pressure, total cholesterol and LDL levels were higher in the postmenopausal group, whereas HDL levels were higher in the premenopausal group (p<0.05). TO was significantly higher, TS was significantly lower in postmenopausal women compared to premenopausal women (-2.76±1.34 vs 0.60±1.30 and 3.60±1.54 vs 1.60±1.48, p=0.000 for both, respectively). TO was positively correlated, TS negatively correlated with age, BMI, systolic and diastolic blood pressure and LDL cholesterol level. According to multivariate analysis only menopausal status and age had an independent effect on HRT parameters. Receiver operating characteristic analysis showed that the cut-off values of TO and TS for predicting menopausal status were 0.959 and 0.165, respectively (0.835 anti-image). These results showed that TO and TS had diagnostic value for predicting menopausal status. Conclusion: Postmenopausal women had blunted HRT response. It is a simple and easily obtainable test and should be implemented in cardiac evaluation in daily practice.

Keywords: Postmenopause; women; heart rate
ÖZET
 Amaç: Bu çalışma, sağlıklı postmenopozal kadınlarda kalp hızı türbülansı (KHT) analizini incelemek için yapıldı. Gereç ve Yöntemler: Çalışmaya, 40 sağlıklı postmenopozal kadın ve 43 düzenli adet gören premenopozal kadın alınmıştır. Tüm bireylere biyokimyasal kan testleri, 2 boyutlu ekokardiyografi ve 24 saatlik Holter monitörizasyonu yapıldı. KHT parametreleri olan türbülans başlangıcı (TB) ve türbülans eğimi (TE) hesaplandı. Bulgular: Postmenopozal grupta yaş, beden kitle indeksi (BKİ), sistolik ve diyastolik kan basıncı, total ve LDL kolesterol seviyeleri daha yüksek iken, HDL seviyesi daha düşük bulundu (p<0,05). Premenopozal kadınlar ile karşılaştırıldığında, postmenopozal kadınların TB değeri belirgin olarak yüksek, TE değeri ise belirgin olarak düşük idi (sırasıyla -2,76±1,34; 0,60±1,30 ve 3,60±1,54; 1,60±1,48, her ikisi için p=0,000). Yaş, BKİ, sistolik ve diyastolik kan basıncı, LDL düzeyi TB ile pozitif, TE ile negatif korelasyon gösterdi. Multivaryant analizine göre sadece menopoz durumu ve yaş, KHT parametreleri üzerinde bağımsız bir etki gösterdi. Alıcı işlem karakteristikleri analizine göre TB ve TE'nin menopozal durumu prediktif değeri sırasıyla 0,959 ve 0,165 idi (0,835 anti-imaj). Bu bulgular TB ve TE'nin menopoz durumunu öngörmede tanısal değeri olduğunu göstermiştir. Sonuç: Postmenopozal kadınlarda, KHT cevabı bozulmuştur. Bu test klinikte oldukça kolay olarak uygulanılabilen basit bir testtir ve postmenopozal kadınların kardiyak değerlendirilmesinde düşünülmelidir.

Anahtar Kelimeler: Postmenapoz; kadınlar; kalp hızı
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