Turkiye Klinikleri Journal of Pediatrics

.: ORIGINAL RESEARCH
Genel Pediatri Servisinde Kullanılan Pediatrik Dozaj Formu Olmayan İlaçların İncelenmesi: Tanımlayıcı Bir Çalışma
Investigation of Medications Without Pediatric Dosage Forms Used in General Pediatric Service: A Descriptive Study
Yunus Emre AYHANa, Cüneyd ENVERa, Betül OKUYANa, Perran BORANb, Mesut SANCARa
aMarmara Üniversitesi Eczacılık Fakültesi, Klinik Eczacılık ABD, İstanbul, Türkiye
bMarmara Üniversitesi Tıp Fakültesi, Sosyal Pediatri BD, İstanbul, Türkiye
Turkiye Klinikleri J Pediatr. 2023;32(1):36-41
doi: 10.5336/pediatr.2022-92519
Article Language: TR
Full Text
ÖZET
 Amaç: Bu çalışmanın amacı, genel pediatri servisinde kullanılan pediatrik dozaj formu olmayan (PDFO) ilaçların saptanmasıdır. Gereç ve Yöntemler: Retrospektif, tanımlayıcı nitelikteki bu çalışma, bir üniversite hastanesinin genel pediatri servisinde son 6 ayda ilaç tedavi almış olan 12 yaş altı hastaların arşiv belgelerindeki ilaç tedavilerinin incelenmesi ile gerçekleştirilmiştir. Bulgular: Çalışmaya dâhil edilen 238 hastanın yaş medyanı [çeyrekler arası aralık (ÇAA)] 2 yıl (1- 6) olup, hastaların 130'unu (%54,6) kız çocuklar oluşturmaktadır. Hastalarda en sık görülen tanılar; diabetes mellitus (%10), üst solunum yolu enfeksiyonları (%8,4) ve pnömonidir (%6,9). Hastaların 96'sında (%40,3) PDFO ilaç kullanımı tespit edilmiştir. Hastaların kullandığı toplam 729 ilacın 106'sı (%14,5) PDFO ilaç olarak nitelendirilmiştir. PDFO ilaçlar arasında en sık kullanılan etken maddeler sırasıyla allopürinol (%6,3), kaptopril (%5), fenobarbital (%5), furosemid (%4,2) ve azatiyoprindir (%4,2). PDFO ilaçlar, en sık kardiyovasküler sistem (%26), sindirim sistemi (%23) ve sinir sistemi (%16) ilaçları şeklinde dağılım göstermiştir. PDFO ilaçların %57'si 0-2 yaş, %24'ü 3-6 yaş, %19'u 7-12 yaş gruplarında kullanılmıştır. PDFO ilaçların bu yaş gruplarındaki hastalar arasında dağılımında istatistiksel olarak anlamlı bir fark görülmemiştir (p>0,05). Sonuç: Genel pediatri servisinde yatan hastalarda PDFO ilaçların yaygın olarak kullanıldığı görülmüştür. Özellikle kardiyovasküler sistem grubundaki ilaçlar, sıklıkla dozaj formları manipüle edilerek kullanılan ilaçlardır. Pediatrik ilaç tedavisinin güvenliğini artırmak amacıyla ilaçların manipülasyonu için kanıta dayalı kılavuzlar gereklidir.

Anahtar Kelimeler: Pediatri; yatan hastalar; dozaj formları
ABSTRACT
 Objective: The aim of this study is to determine the nonpediatric dosage form (NPDF) of medications used in the general pediatric service. Material and Methods: This retrospective, descriptive study was carried out by examining the archive documents of patients under the age of 12 who had received medication therapy in the last 6 months in the general pediatric service of a university hospital. Results: The median age [interquartile range (IQR)] of the 238 patients included in the study was 2 years (1-6), and 130 (54.6%) of them were female. The most common diagnoses in patients are diabetes mellitus (10%), upper respiratory tract infections (8.4%) and pneumonia (6.9%), NPDF medications use was detected in 96 (40.3%) of the patients. Out of a total of 729 medications used by the patients, 106 (14.5%) were classified as NPDF medications. The most commonly used active ingredients among NPDF medications are allopurinol (6.3%), captopril (5%), phenobarbital (5%), furosemide (4.2%) and azathioprine (4.2%). NPDF medications were most frequently included in the cardiovascular system (26%), the digestive system (23%) and the nervous system (16%). Of the NPDF drugs, 57% were used in the 0-2 age group, 24% in the 3- 6 age group, and 19% in the 7-12 age group. There was no statistically significant difference in the distribution of NPDF drugs among patients in these age groups (p>0.05). Conclusion: It has been observed that NPDF medications are widely used in patients hospitalized in the general pediatric service. Especially the medications in the cardiovascular system group are drugs that are often used by manipulating their dosage forms. Evidence-based guidelines for the manipulation of medications are needed to improve the safety of pediatric medication therapy.

Keywords: Pediatric; inpatients; dosage forms
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