Turkiye Klinikleri Journal of Anesthesiology Reanimation

.: CASE REPORTS
Filgrastim Kullanımına Bağlı Spontan Dalak Rüptürü ve Kapiller Kaçış Sendromu
Spontaneous Splenic Rupture and Capillary Leak Syndrome Due to Filgrastim Use
Abdulkadir YEKTAŞa
aDiyarbakır Sağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Anesteziyoloji ve Reanimasyon ABD, Yoğun Bakım Yan Dal Kliniği, Diyarbakır, TÜRKİYE
Turkiye Klinikleri J Anest Reanim. 2020;18(2):62-7
doi: 10.5336/anesthe.2020-74073
Article Language: TR
Full Text
ÖZET
 Filgrastim, kan hücrelerinin çoğalmasını ve farklılaşmasını sağlayan bir hematopoietik büyüme faktörüdür. Spontan dalak rüptürü ve kapiller kaçış sendromu, filgrastim tedavisinin ciddi yan etkilerindendir. Patlama yaralanması sonrası yoğun bakımda ezilme hasarı (Crush sendromu) ve sepsis tanılarıyla izlenen ve beyaz kan hücresi sayısında düşme nedeni ile filgrastim uygulanan hastada gözlenen kapiller kaçış sendromu ve spontan dalak rüptürü komplikasyonlarına yaklaşım sunulmaktadır. Filgrastim, spontan dalak rüptürü ve kapiller kaçış sendromuna neden olabilir. Filgrastim kullanımında hastaların dalakları periyodik olarak kontrol edilmelidir.

Anahtar Kelimeler: Filgrastim; kapiller kaçış sendromu; spontan dalak rüptürü
ABSTRACT
 Filgrastim is a hematopoietic growth factor that allows blood cells to proliferate and differentiate. Spontaneous splenic rupture and capillary leak syndrome are serious side effects of filgrastim therapy. The patient was followed up in the intensive care unit after burst injury with Crush syndrome and sepsis. Filgrastim was applied due to a decrease in the white blood cell count. The patient's approach to capillary leak syndrome and spontaneous splenic rupture complications is presented. Filgrastim can cause spontaneous splenic rupture and capillary leak syndrome. Splenic should be checked periodically during the use of filgrastim.

Keywords: Filgrastim; capillary leak syndrome; spontaneous splenic rupture
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