Fetal cerrahi, klinik araştırmaların beraberinde inovatif çalışmalarla hızla gelişen, disiplinler arasında karşılıklı iş birliğinin zorunlu olduğu, etiğin temel bileşen olduğu bir disiplindir. Pediatrik ve obstetrik anestezi uygulamalarının bütünleşmesini gerektirir. Gebe hasta ve fetüs olmak üzere 2 hasta vardır, fetüsün iyiliği için 2 hastaya anestezi uygulanır ve hata yapma aralığı çok dardır. Fetal cerrahi minimal invaziv işlemlerden, açık cerrahi işlemlere kadar geniş aralığa dağılır. Minimal invaziv işlemler genellikle hafif sedasyon ve lokal anestezi ile yapılır, nadiren nöroaksiyel anestezi ve genel anestezi gerekir. Ultrasonografi kılavuzluğunda yapılan perkütan girişimler eş zamanlı ultrasonografi ile görüntülenirken, perkütan uygulanan fetoskopik kameralar kılavuzluğunda fetal endoskoplarla cerrahi gerçekleştirilir. Fetal ekokardiyografi, umbilikal kordun Doppler ultrasonografisi, fetal puls oksimetri uygulamaları temel fetus monitorizasyon metodlarıdır. Cerrahi işlem sırasında mutlaka fetal analjezi uygulanmalıdır. Açık işlemler anne genel anestezi altında iken uygulanır. Açık işlemlerde fetal kardiyak fonksiyonlar izlenmeli, uterus gevşemesi, uteroplasental perfüzyonun devamı sağlanmalıdır. Fetüs, uterus kavitesine döner ve gelişimine devam eder. Ex utero intrapartum cerrahiler, sezaryen ameliyatlarının modifikasyonudur, plasenta desteği devam ederken, fetüsün uterus dışında yaşamını sürdürmesini sağlayacak cerrahi işlemler uygulanır. Bebek doğduktan sonra tokoliz sonlandırılarak, uterusun kasılması sağlanır. Ameliyathanede yenidoğanı karşılayacak 2. bir cerrahi ekibin bulunması gerekebilir. Bu derlemede, maternal-fetal cerrahide etik yaklaşım, preoperatif hazırlık, fetal cerrahi girişimler, fetüsün analjezi ve anestezisi, annenin anestezisi, fetüsün monitörizasyonu gözden geçirilmektedir.
Anahtar Kelimeler: Fetal anestezi; fetal cerrahi; obstetrik anestezi
Fetal surgery is a discipline that develops rapidly with clinical researches and innovative studies, mutual cooperation between disciplines is obligatory, and ethics is one of the main components. It requires the integration of pediatric and obstetric anesthesia. There are 2 patients, a pregnant patient and a fetus, 2 patients are anesthetized for the sake of the fetus, and the error range is very narrow. Fetal surgery ranges from minimally invasive procedures to open surgical procedures. Minimally invasive procedures are usually performed with mild sedation and local anesthesia, rarely neuraxial anesthesia and general anesthesia are required. These are percutaneous interventions under ultrasound guidance or surgery is performed with fetal endoscopes under the guidance of percutaneously applied fetoscopic cameras, while simultaneous ultrasound imaging. Fetal echocardiography, Doppler ultrasonography of umbilical cord, fetal pulsoximetry are the basic fetal monitorings. Open procedures are performed while the mother is under general anesthesia. Fetal cardiac monitoring, uterine relaxation and continuation of uteroplacental perfusion. Fetal analgesia should be ensured during surgical procedures. Conclusion of intervention the fetus returns to the uterine cavity and continues its development. Ex utero intrapartum surgeries are modifications of cesarean sections. While the placental support continues, surgical procedures are applied to ensure the fetus to survive outside the uterus. After the delivery, tocolysis is terminated and the uterus is contracted. A 2nd surgical team should be in the operating room to evaluates the neonate and acts according to the neonate's requirements at birth in some cases. In this review, ethical approach, preoperative preparation, surgical interventions, fetal analgesia and anesthesia, maternal anesthesia, fetal monitoring are reviewed.
Keywords: Fetal surgery; fetal anesthesia; obstetric anesthesia
- Lin EE, Tran KM. Anesthesia for fetal surgery. Semin Pediatr Surg. 2013;22(1):50-5. [Crossref] [PubMed]
- Codsi E, Audibert F. Fetal surgery: Past, present, and future perspectives. J Obstet Gynaecol Can. 2019;41 Suppl 2:S287-S9. [Crossref] [PubMed]
- Chervenak FA, McCullough LB. The ethics of maternal-fetal surgery. Semin Fetal Neonatal Med. 2018;23(1):64-7. [Crossref] [PubMed]
- Sviggum HP, Kodali BS. Maternal anesthesia for fetal surgery. Clin Perinatol. 2013;40(3): 413-27. [Crossref] [PubMed]
- Ferschl MB, Rollins MD. Anesthesia for fetal surgery and other fetal therapies. In: Gropper MA, Eriksson LI, eds. Miller's Anesthesia. 9th ed. Philadelphia, PA: Elsevier; 2020. p.2042-70. [Link]
- Everett TR, Pratt R, Butler CR, Hewitt RJ, Coppi P, Pandya PV. Fetal tumours. In: Pandya PP, Sebire NJ, Oepkes D, Wapner RJ, eds. Fetal Medicine. 3rd ed. China: Elsevier.; 2020. p.443-53.e2. [Crossref]
- Lee H, Hirose S, Harrison MR. Prenatal diagnosis and fetal therapy. In: Coran AG, ed. Pediatric Surgery. 7th ed. Philadelphia: Elsevier Saunders; 2012. p.77-85. [Crossref]
- Antiel RM, Flake AW, Collura CA, Johnson MP, Rintoul NE, Lantos JD, et al. Weighing the social and ethical considerations of maternal-fetal surgery. Pediatrics. 2017;140(6):e2017 0608. [Crossref] [PubMed]
- American College of Obstetricians and Gynecologists Committee on Ethics, American Academy of Pediatrics Committee on Bioethics. Maternal-Fetal Intervention and Fetal Care Centers. Number 501. 2011. [Link]
- Ring LE, Ginosar Y. Anesthesia for fetal surgery and fetal procedures. Clin Peri- natol. 2019;46(4):801-16. [Crossref] [PubMed]
- Rollins M. Anesthesia for fetal surgery and other intrauterine procedures. In: Chesnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre JM, Bateman BT, eds. Chestnut's Obstetric Anesthesia: Principles and Practices. 6th ed. Philadelphia, PA: Elsevier.; 2020. p.132-54. [Link]
- Bauchat JR, de Velde MV. Nonobstetric surgery during pregnancy. In: Chesnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre JM, Bateman BT. eds. Chestnut's Obstetric Anesthesia: Principles and Practices. 6th ed. China: Elsevier. 2019. p.368-91. [Link]
- Baumgarten HD, Flake AW. Fetal surgery. Pediatr Clin North Am. 2019;66(2):295-308. [Crossref] [PubMed]
- Sharpe EE, Arendt KW. Anesthesia for obstetrics. In: Gropper MA, Eriksson LI, eds. Miller's Anesthesia. 9th ed. Philadelphia, PA: Elsevier; 2020. p.2006-41. [Link]
- Van de Velde M, De Buck F. Fetal and maternal analgesia/anesthesia for fetal procedures. Fetal Diagn Ther. 2012;31(4):201-9. [Crossref] [PubMed]
- Tran KM, Chatterjee D. New trends in fetal anesthesia. Anesthesiol Clin. 2020;38(3):605-19. [Crossref] [PubMed]
- Graves CE, Harrison MR, Padilla BE. Minimally invasive fetal surgery. Clin Perinatol. 2017;44(4):729-51. [Crossref] [PubMed]
- Sun LS, Li G, Miller TL, Salorio C, Byrne MW, Bellinger DC, et al. Association between a single general anesthesia exposure before age 36 months and neurocognitive outcomes in later childhood. JAMA. 2016;315(21):2312-20. [Crossref] [PubMed] [PMC]
- Tran KM, Cohen DE. Anesthesia for fetal surgery. In: Davis PJ, Cladis FP, eds. Smith's Anesthesia for Infants and Children. 9th ed. Phila delphia, PA: Elsevier; 2017. p.617-32.e5. [Link]
- Brusseau R, Mizrahi-Arnaud A. Fetal anesthesia and pain management for intrauterine therapy. Clin Perinatol. 2013;40(3):429-42. [Crossref] [PubMed]
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