Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Farklı Kalınlıktaki Biyoaktif Rezin Materyalin Optik Özelliklerinin Araştırılması: İn Vitro Çalışma
Investigation of Optical Properties of a Bioactive Resin Material in Different Thickness: An In Vitro Study
Seda Nur KARAKAŞa , Cihan KÜDENb
aÇukurova Üniversitesi Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi ABD, Adana, Türkiye
bÇukurova Üniversitesi Diş Hekimliği Fakültesi, Endodonti ABD, Adana, Türkiye
Turkiye Klinikleri J Dental Sci. 2023;29(3):481-90
doi: 10.5336/dentalsci.2022-94383
Article Language: TR
Full Text
ÖZET
 Amaç: Bu çalışma farklı kalınlıklardaki biyoaktif restoratif materyalin (ACTIVA), polimerizasyon ve yapay tükürükte yaşlandırma sonrası renk değişimi ve optik özelliklerini anterior ve posterior kompozit rezinlerle karşılaştırmıştır. Gereç ve Yöntemler: ACTIVA (AC) ve G-aenial anterior (GCa) ve G-aenial Posterior (GCp) kompozit rezin örnekleri, 10 mm çapında, 1- ve 2-mm kalınlığında altı grup (n=10) olarak hazırlandı. Grupların renk parametreleri bir spektrofotometre ile ölçüldü. Polimerizasyon ve yapay tükürükte yaşlandırılma sonrası renk değişimi ve translüsentlik parametresi (TP) CIEDE2000 formülü kullanılarak bulundu. Ayrıca kontrast oranı [contrast ratio (CR)] hesaplandı. Veriler tek yönlü ANOVA ve post-hoc Tukey testleri ile analiz edildi (α=0,05). Bulgular: Polimerizasyon sonrası tüm grupların rengi önemli ölçüde değişti (p<0,001). GCp grubu hariç diğer gruplar her iki materyal kalınlığı için 7 ve 14 gün yaşlandırma sonrasında kabul edilebilirlik eşiğinin (1,8) altında renk değişimi gösterdiler. Materyal kalınlığı AC ve GCp grubunun renk değişimini önemli ölçüde etkilemiştir (p<0,05). Kalınlık 1 mm olan gruplar arasında tüm ölçüm zamanları için en düşük TP değeri AC ve en yüksek GCp gruplarında izlendi (p<0,05). Kalınlık 1 mm grupları için CR değerleri TP değerleri tamamen ters orantılıydı. Sonuç: Materyal kalınlığı AC'nin yaşlandırma sonrası renk değişiminde önemlidir. Polimerizasyon ve yaşlandırma sonrasında AC, GCa'ya göre daha fazla renk değişimi göstermiştir, ancak GCp'ye göre daha stabildir. Bununla birlikte AC, kompozit gruplarına göre daha az TP ve daha yüksek CR değerlerine sahiptir.

Anahtar Kelimeler: ACTIVA bioaktif-restoratif; renk; polimerizasyon; spektrofotometre
ABSTRACT
 Objective: This study compared the color change and optical properties of bioactive restorative material (ACTIVA) set at the different thicknesses with anterior and posterior composite resins after polymerization, and aging in artificial saliva. Material and Methods: The samples of ACTIVA (AC), and G-aenial anterior (GCa) and G-aenial Posterior (GCp) composite resins were prepared in 6 groups (n=10) with a diameter of 10 mm and thicknesses of 1- and 2-mm. The color parameters of the groups were measured with a spectrophotometer. The color change and translucency parameter (TP) after polymerization, and aging in artificial saliva were found using the CIEDE2000 formula. In addition, the contrast ratio (CR) was calculated. The data were analyzed with one-way ANOVA and post-hoc Tukey tests (α=0.05). Results: The color of all groups changed significantly after polymerization (p<0.001). Except the GCp group, the other groups showed color change below the acceptability threshold (1.8) after 7 and 14 days of aging for both material thicknesses. Material thickness significantly affected the color change of AC and GCp groups (p<0.05). Among the groups with 1 mm thickness, the lowest TP value was observed in the AC and the highest GCp groups for all measurement times (p<0.05). The CR values for the thickness 1 mm groups were completely inversely proportional to the TP values. Conclusion: The material thickness is important in the color change of AC after aging. After polymerization and aging, AC showed more color change than GCa but more stable than GCp. However, AC has lower TP and higher CR values than composite groups.

Keywords: ACTIVA bioactive-restorative; color; polymerization; spectrophotometry
REFERENCES:
  1. Tay FR, Pashley DH. Guided tissue remineralisation of partially demineralised human dentine. Biomaterials. 2008;29(8):1127-37. [Crossref]  [PubMed] 
  2. Garoushi S, Vallittu PK, Lassila L. Characterization of fluoride releasing restorative dental materials. Dent Mater J. 2018;37(2):293-300. [Crossref]  [PubMed] 
  3. Çelık EU, Aladağ A, Türkün LŞ, Yilmaz G. Color changes of dental resin composites before and after polymerization and storage in water. J Esthet Restor Dent. 2011;23(3):179-88. [Crossref]  [PubMed] 
  4. Patel SB, Gordan VV, Barrett AA, Shen C. The effect of surface finishing and storage solutions on the color stability of resin-based composites. J Am Dent Assoc. 2004;135(5):587-94; quiz 654. [Crossref]  [PubMed] 
  5. Taira M, Okazaki M, Takahashi J. Studies on optical properties of two commercial visible-light-cured composite resins by diffuse reflectance measurements. J Oral Rehabil. 1999;26(4):329-37. [Crossref]  [PubMed] 
  6. Kim IJ, Lee YK. Changes in color and color parameters of dental resin composites after polymerization. J Biomed Mater Res B Appl Biomater. 2007;80(2):541-6. [Crossref]  [PubMed] 
  7. Sidhu SK, Ikeda T, Omata Y, Fujita M, Sano H. Change of color and translucency by light curing in resin composites. Oper Dent. 2006;31(5):598-603. [Crossref]  [PubMed] 
  8. Durand LB, Ruiz-López J, Perez BG, Ionescu AM, Carrillo-Pérez F, Ghinea R, et al. Color, lightness, chroma, hue, and translucency adjustment potential of resin composites using CIEDE2000 color difference formula. J Esthet Restor Dent. 2021;33(6):836-43. [Crossref]  [PubMed] 
  9. Tauböck TT, Tarle Z, Marovic D, Attin T. Pre-heating of high-viscosity bulk-fill resin composites: effects on shrinkage force and monomer conversion. J Dent. 2015;43(11):1358-64. [Crossref]  [PubMed] 
  10. Miyagawa Y, Powers JM, O'Brien WJ. Optical properties of direct restorative materials. J Dent Res. 1981;60(5):890-4. [Crossref]  [PubMed] 
  11. Betrisey E, Krejci I, Di Bella E, Ardu S. The influence of stratification on color and appearance of resin composites. Odontology. 2016;104(2):176-83. [Crossref]  [PubMed] 
  12. Ardu S, Rossier I, di Bella E, Krejci I, Dietschi D. Resin composite thickness' influence on L*a*b* coordinates and translucency. Clin Oral Investig. 2019;23(4):1583-6. [Crossref]  [PubMed] 
  13. Guler S, Unal M. The evaluation of color and surface roughness changes in resin based restorative materials with different contents after waiting in various liquids: an SEM and AFM study. Microsc Res Tech. 2018;81(12):1422-33. [Crossref]  [PubMed] 
  14. Salas M, Lucena C, Herrera LJ, Yebra A, Della Bona A, Pérez MM. Translucency thresholds for dental materials. Dent Mater. 2018;34(8):1168-74. [Crossref]  [PubMed] 
  15. Yu B, Ahn JS, Lee YK. Measurement of translucency of tooth enamel and dentin. Acta Odontol Scand. 2009;67(1):57-64. [Crossref]  [PubMed] 
  16. Nogueira AD, Della Bona A. The effect of a coupling medium on color and translucency of CAD-CAM ceramics. J Dent. 2013;41 Suppl 3:e18-23. [Crossref]  [PubMed] 
  17. Paravina RD, Ghinea R, Herrera LJ, Bona AD, Igiel C, Linninger M, et al. Color difference thresholds in dentistry. J Esthet Restor Dent. 2015;27 Suppl 1:S1-9. [Crossref]  [PubMed] 
  18. Prodan DA, Gasparik C, Mada DC, Miclăuş V, Băciuţ M, Dudea D. Influence of opacity on the color stability of a nanocomposite. Clin Oral Investig. 2015;19(4):867-75. [Crossref]  [PubMed] 
  19. Ardu S, Braut V, Di Bella E, Lefever D. Influence of background on natural tooth colour coordinates: an in vivo evaluation. Odontology. 2014;102(2):267-71. [Crossref]  [PubMed] 
  20. Ardu S, Braut V, Gutemberg D, Krejci I, Dietschi D, Feilzer AJ. A long-term laboratory test on staining susceptibility of esthetic composite resin materials. Quintessence Int. 2010;41(8):695-702. [PubMed] 
  21. Kilinc E, Antonson SA, Hardigan PC, Kesercioglu A. Resin cement color stability and its influence on the final shade of all-ceramics. J Dent. 2011;39 Suppl 1:e30-6. [Crossref]  [PubMed] 
  22. Albuquerque PP, Moreira AD, Moraes RR, Cavalcante LM, Schneider LF. Color stability, conversion, water sorption and solubility of dental composites formulated with different photoinitiator systems. J Dent. 2013;41 Suppl 3:e67-72. [Crossref]  [PubMed] 
  23. Ertaş E, Güler AU, Yücel AC, Köprülü H, Güler E. Color stability of resin composites after immersion in different drinks. Dent Mater J. 2006;25(2):371-6. [Crossref]  [PubMed] 
  24. Oliveira DC, Souza-Júnior EJ, Prieto LT, Coppini EK, Maia RR, Paulillo LA. Color stability and polymerization behavior of direct esthetic restorations. J Esthet Restor Dent. 2014;26(4):288-95. [Crossref]  [PubMed] 
  25. Barutcigil Ç, Yıldız M. Intrinsic and extrinsic discoloration of dimethacrylate and silorane based composites. J Dent. 2012;40 Suppl 1:e57-63. [Crossref]  [PubMed] 
  26. Barutcigil C, Harorli OT, Yildiz M, Ozcan E, Arslan H, Bayindir F. The color differences of direct esthetic restorative materials after setting and compared with a shade guide. J Am Dent Assoc. 2011;142(6):658-65. [Crossref]  [PubMed] 
  27. Hadis MA, Shortall AC, Palin WM. Competitive light absorbers in photoactive dental resin-based materials. Dent Mater. 2012;28(8):831-41. [Crossref]  [PubMed] 
  28. Barutcigil Ç, Barutcigil K, Özarslan MM, Dündar A, Yilmaz B. Color of bulk-fill composite resin restorative materials. J Esthet Restor Dent. 2018;30(2):E3-E8. [Crossref]  [PubMed] 
  29. Lee YK. Translucency of human teeth and dental restorative materials and its clinical relevance. J Biomed Opt. 2015;20(4):045002. [Crossref]  [PubMed] 
  30. Hasegawa A, Ikeda I, Kawaguchi S. Color and translucency of in vivo natural central incisors. J Prosthet Dent. 2000;83(4):418-23. [Crossref]  [PubMed] 
  31. Kim EH, Jung KH, Son SA, Hur B, Kwon YH, Park JK. Effect of resin thickness on the microhardness and optical properties of bulk-fill resin composites. Restor Dent Endod. 2015;40(2):128-35. [Crossref]  [PubMed]  [PMC] 
  32. Ryan EA, Tam LE, McComb D. Comparative translucency of esthetic composite resin restorative materials. J Can Dent Assoc. 2010;76:a84. [PubMed] 
  33. Lee YK. Influence of filler on the difference between the transmitted and reflected colors of experimental resin composites. Dent Mater. 2008;24(9):1243-7. [Crossref]  [PubMed] 
  34. Ilie N, Bucuta S, Draenert M. Bulk-fill resin-based composites: an in vitro assessment of their mechanical performance. Oper Dent. 2013;38(6):618-25. [Crossref]  [PubMed] 
  35. Czasch P, Ilie N. In vitro comparison of mechanical properties and degree of cure of bulk fill composites. Clin Oral Investig. 2013;17(1):227-35. [Crossref]  [PubMed] 

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