Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Factors Related to the Donor on the Graft Adherence in Descemet's Membrane Endothelial Keratoplasty: Descriptive Study
Desme Membran Endotelyal Keratoplasti Başarısını Etkileyen Donöre Ait Faktörler: Tanımlayıcı Araştırma
Burcu KASIMa, Yusuf KOÇLUKa, Burak ÖZKANa
aClinic of Ophthalmology, Adana City Training and Research Hospital, Adana, Türkiye
Turkiye Klinikleri J Ophthalmol. 2022;31(4):254-9
doi: 10.5336/ophthal.2022-90151
Article Language: EN
Full Text
ABSTRACT
 Objective: To analyze the effect of the characteristics of the donor and the preparation of donor graft in the success of Descemet's membrane endothelial keratoplasty (DMEK). Material and Methods: The patient and donor charts and the surgical videos of the cases that underwent DMEK between June 2017 and June 2020 were analyzed. Age, gender, diagnosis, Descemet's membrane (DM) attachment at the postoperative first week and the last visit from the patients' charts and age, gender, systemic diseases, and drugs from the donors' charts. The cases were divided into 2 groups; the cases with DM detachment (Group 1) and attached DM (Group 2) at the postoperative first week. Results: Fifty-three DMEK surgeries from 53 recipients with 53 DM grafts from 41 donors were analyzed. On the first postoperative week, DM was detached in 8 (15.1%, Group 1) cases and attached in 45 (84.9%, Group 2) cases. There were no statistically significant differences in the characteristics of the recipient or donor between groups. However, the amlodipine and doxazosin use of donors were found to be significantly higher in Group 1 (p=0.041, p=0.011; respectively). Conclusion: DM grafts may be used, regardless of the characteristics of the donor, in DMEK to compensate for the shortage of donors.

Keywords: Descemet's membrane endothelial keratoplasty; donor; graft adherence; systemic diseases
ÖZET
 Amaç: Desme membran endotelyal keratoplasti (DMEK) başarısında donöre ait ve donör hazırlama sırasındaki özelliklerin etkisini değerlendirmektir. Gereç ve Yöntemler: Haziran 2017-Haziran 2020 tarihleri arasında DMEK uygulanan olgulara ait hasta kartları ve cerrahi videolar incelendi. Hasta kartlarından yaş, cinsiyet ve tanı kaydedildi. Ayrıca ameliyat sonrası 1. haftada ve son muayenede Desme membranının (DM) durumu (yatışık veya dekole) değerlendirildi. Donör yaşı, cinsiyeti, sistemik hastalıkları ve kullandığı sistemik ilaç bilgileri donörün hastane dosyasından elde edildi. Olgular, ameliyat sonrası 1. haftada, DM dekolmanı olan (1. Grup) ve DM yatışık olan (2. Grup) olarak 2 gruba ayrıldı. Bulgular: Kırk bir donöre ait 53 DM greft ile DMEK uygulanan 53 olgunun 53 gözü çalışmaya dâhil edildi. Ameliyat sonrası 1. haftada DM 8 (%15,1, 1. Grup) olguda dekole, 45 (%84,9, 2. Grup) olguda ise yatışık olarak izlendi. Gruplar arasında alıcı ve donör özellikleri açısından istatistiksel olarak anlamlı fark saptanmadı. Ancak donörlerde amlodipin ve doksazosin kullanımı 1. Grupta anlamlı olarak fazla bulundu (p=0,041, p=0,011; sırasıyla). Sonuç: Donör eksikliği göz önünde bulundurulduğunda, DM greftleri, donör özelliklerine bakılmaksızın DMEK'de kullanılabili

Anahtar Kelimeler: Desme membran endotelyal keratoplasti; donör; greft yatışıklığı; sistemik hastalıklar
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