Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
Examination of Brain-Derived Neurotrophic Factor, Glial Cell Line-Derived Neurotrophic Factor, and Neurotrophin-3 Levels and Brain Volumes in Shift-Working Men: Clinical Research
Nöbetli Çalışan Erkeklerde Beyin Kökenli Nörotrofik Faktör, Glial Hücre Dizisinden Kaynaklanan Nörotrofik Faktör ve Nörotrofin-3 Düzeylerinin ve Beyin Hacimlerinin İncelenmesi: Klinik Araştırma
Mücahide Büşra BALCIOĞLUa, Dilek KUZAY AKSOYb, Görkem TUTAL GÜRSOYc, Esra OĞUZ FIRATd, Elvan Evrim TUNAe, Niyazi ACERf
aDepartment of Molecular Medicine, Kırşehir Ahi Evran University Institute of Health Sciences, Kırşehir, Türkiye
bDepartment of Physiology, Kırşehir Ahi Evran University Faculty of Medicine, Kırşehir, Türkiye
cClinic of Neurology, Ankara City Hospital, Ankara, Türkiye
dClinic of Medical Biochemistry, Ankara City Hospital, Ankara, Türkiye
eClinic of Otolaryngology, Ankara City Hospital, Ankara, Türkiye
fDepartment of Anatomy, İstanbul Arel University Faculty of Medicine, İstanbul, Türkiye
Turkiye Klinikleri J Med Sci. 2023;43(1):40-8
doi: 10.5336/medsci.2022-94617
Article Language: EN
Full Text
ABSTRACT
 Objective: This study aims to examine the levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) and brain volumes in shift-working men. Material and Methods: Forty-nine men who have been working in shifts for at least 1 year were included in the study. Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, Montreal Cognitive Assessment (MoCA) test and trail making test (TMT) were used to assess cognitive performance, and Beck Anxiety Inventory (BAI) was used to assess anxiety level. Afterwards, plasma BDNF, GDNF and NT-3 levels were examined. Brain volume measurement was performed. Results: Since the PSQI results of shift-working men were above 5, it was determined that they had 'poor sleep quality'. According to the BAI results, 85% of them had anxiety. Primary-secondary school graduate shift-working men had lower MoCA value and TMT-A and TMT-B test scores were higher (p <0.05).Working in shifts for 6 years or more caused a significant decrease in BDNF and NT-3 levels (p<0.05). According to the correlation analysis results, it was observed that the prefrontal cortex, dorsolateral prefrontal cortex and cerebral cortex in the left lobe of the brain were smaller in elderly shift workers (p<0.05). Conclusion: There is a decrease in BDNF and NT-3 levels in shift workers of 6 years or more. Some brain regions associated with learning and memory have been found to be in smaller volumes in older shift workers.

Keywords: Sleep disorders; circadian rhythm; shift work schedule; neurotrophic factor; neurotrophin-3
ÖZET
 Amaç: Bu çalışmanın amacı, nöbetli çalışan erkeklerde beyin kökenli nörotrofik faktör [brain-derived neurotrophic factor (BDNF)], glial hücre dizisinden kaynaklanan nörotrofik faktör [glial cell line-derived neurotrophic factor (GDNF)] ve nörotrofin-3 (NT-3) düzeylerinin ve beyin hacimlerinin incelenmesidir. Gereç ve Yöntemler: Çalışmaya en az 1 yıldır nöbetli çalışan 49 erkek dâhil edilmiştir. Uyku kalitesini değerlendirmek amacıyla Pittsburgh Uyku Kalitesi İndeksi (PUKİ), bilişsel performansi değerlendirmek için Montreal Bilişsel Değerlendirme [Montreal Cognitive Assessment (MoCA)] ve iz sürme testi [trail making test (TMT)], anksiyete düzeyini değerlendirmek için Beck Anksiyete Ölçeği (BAÖ) uygulanmıştır. Sonrasında plazmada BDNF, GDNF ve NT-3 düzeyleri incelenmiştir. Beyin hacim ölçümü yapılmıştır. Bulgular: Çalışmamız sonuçlarına göre vardiyali çalişanlarin PUKİ sonuçları 5'in üzerinde olduğu için 'kötü uyku kalitesine' sahip olduğu tespit edilmiştir. BAÖ sonuçlarına göre %85'inin anksiyeteye sahip oldukları görülmüştür. İlkokul-ortaokul mezunu vardiyalı çalışanların MoCA değerinin daha düşük, TMT-A ve TMT-B testi puanlarının ise daha yüksek olduğu görülmüştür (p <0,05). Altı yıl ve daha fazla vardiyalı çalışanların BDNF ve NT-3 düzeylerinin önemli düzeyde azaldığı belirlenmiştir (p<0,05). Korelasyon analizi sonuçlarına göre ileri yaştaki vardiyalı çalışanlarda beynin sol lobundaki prefrontal korteks, dorsolateral prefrontal korteks ve serebral korteksin daha küçük olduğu görülmüştür (p<0,05). Sonuç: Vardiyalı çalışma sisteminin uyku bozukluğu ve anksiyeteye neden olduğu tespit edilmiştir. Altı yıl ve daha fazla vardiyalı çalışanlarda BDNF ve NT-3 düzeylerinde azalma olduğu belirlenmiştir. İleri yaş vardiyalı çalışanlarda öğrenme ve bellek ile ilişkili bazı beyin bölgelerinin daha küçük hacimlerde olduğu tespit edilmiştir.

Anahtar Kelimeler: Uyku bozuklukları; sirkadiyen ritim; vardiyalı çalışma takvimi; nörotrofik faktör; nörotrofin-3
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Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

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