Journal of Literature Pharmacy Sciences

.: ORIGINAL RESEARCH
Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study
Proton Pompası İnhibitörleri ile Potansiyel İlaç Etkileşimlerinin Değerlendirilmesi: Retrospektif Bir Çalışma
Beyza Nur BAYUKa, İzel DEDEb, Songül TEZCANb
aDepartment of Clinical Pharmacy, Marmara University Institute of Health Science, İstanbul, Türkiye
bDepartment of Clinical Pharmacy, Marmara University Faculty of Pharmacy, İstanbul, Türkiye
J Lit Pharm Sci. 2023;12(1):1-7
doi: 10.5336/pharmsci.2022-94331
Article Language: EN
Full Text
ABSTRACT
 Objective: Proton pump inhibitors (PPIs) are the most prescribed gastrointestinal system medications and are often prescribed together with other medications. This may lead to drug interactions. In our study, it was aimed to determine the possible interactions of PPIs. Material and Methods: This retrospective study was conducted between January 1, 2021 and March 31, 2021. A prescription review was conducted in a community pharmacy in İstanbul and potential drug interactions were evaluated using the Medscape and Lexicomp databases. Results: A total of 114 prescriptions were reviewed. The mean age of the patients was 55.1±14.8 years, and the mean duration of PPIs use was 5 months. It was determined that the one who prescribed PPIs the most was the family physician and it was prescribed most frequently with the indication of gastroesophageal reflux disease. The total number of interactions in the prescriptions was determined as 248 in the Medscape database and 295 in the Lexicomp database (p<0.05). Pantoprazole was found to be the most interacting PPIs in both databases. Levothyroxine was found to be the drug that interacted most with PPIs in both databases. Age and duration of PPIs use were found to be positively significantly correlated (p<0.05). Conclusion: In our study, the number of potential drug interactions in prescriptions containing PPIs was found to be high. We think that the possible interactions and duration of use of drugs used due to comorbid diseases should be considered in prescriptions containing PPIs.

Keywords: Proton pump inhibitors; drug interactions; clinical pharmacy; prescriptions
ÖZET
 Amaç: Proton pompası inhibitörleri (PPI) en çok reçete edilen gastrointestinal sistem ilaçları olup, diğer ilaç gruplarıyla birlikte sıklıkla reçete edilmektedir. Bu durum, ilaç etkileşimlerine yol açabilmektedir. Çalışmamızda PPI ilaçlarının olası etkileşimlerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Bu retrospektif çalışma 1 Ocak 2021 ile 31 Mart 2021 tarihleri arasında yapılmıştır. İstanbul'da bir serbest eczanede reçete incelemesi yapılmış ve ilaç etkileşimleri Medscape ve Lexicomp veri tabanları kullanılarak değerlendirilmiştir. Bulgular: Toplam 114 reçete gözden geçirilmiştir. Hastaların yaş ortalaması 55,1±14,8 yıl, ortalama PPI kullanım süresi 5 ay olarak tespit edilmiştir. En sık PPI yazan hekimin aile hekimi olduğu ve en sık gastroözofageal reflü hastalığı endikasyonu ile reçete edildiği belirlenmiştir. Reçetelerdeki toplam etkileşim sayısı Medscape veri tabanında 248, Lexicomp veri tabanında 295 olarak belirlenmiştir (p <0,05). Pantoprazol, her iki veritabanında da en çok etkileşime giren PPI olarak bulunmuştur. Levotiroksin, her iki veri tabanında da PPI'lar ile en çok etkileşime giren ilaç olarak bulunmuştur. PPI kullanım süresi ile yaş arasında pozitif yönde anlamlı bir ilişki bulunmuştur (p<0,05). Sonuç: Çalışmamızda PPI içeren reçetelerdeki ilaç etkileşimlerinin sayısı yüksek bulunmuştur. PPI içeren reçetelerde komorbid hastalıklar nedeniyle kullanılan ilaçların olası etkileşimlerinin ve kullanım sürelerinin dikkate alınması gerektiğini düşünüyoruz.

Anahtar Kelimeler: Proton pompa inhibitörleri; ilaç etkileşimleri; klinik eczacı; reçeteler
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